2. UroToday Home
  3. Conference Highlights
  4. World Congress of Endourology 2017

WCE 2017: The Role of Various Novel Inflammatory Biomarkers Following Flexible Ureterorenoscopy, for the Treatment of Kidney Stones

Vancouver, Canada (UroToday.com) Dr. Stephan Hughes and colleagues examined how flexible ureterorenoscopy (FURS) affected changes to novel inflammatory markers. He discussed that there was an increase of post-operative complications (e.g. infection) with an increase of using FURS. Specifically, there was a 63% increase in hospital admission cases for kidney stones in England (UK) during the past decade. In 2014-2015, there was 86,742 cases reported. However, there was few studies discussing the inflammatory responses after the FURS. 

Forty patients undergoing the FURS for kidney stones participated in the study. Demographics included 26 males and 14 females with the age between 27 and 87 years old (Median = 49 years old). The patients were treated with standardized protocol using the Olympus P5 Flexible Ureterorenoscope. Blood samples were collected pre-operative as baseline level. Follow-up blood samples were collected at 30, 120, and 240 minutes after the procedure. A Bio-Rad Bio-Plex 100 analyser was used to measure four specific inflammatory markers including IL-10, MCP-1, IL-6, VEGF, and MIP-1α.

The results showed that the level of VGEF (p = 0.01) and IL-6 (p = 0.07) increased after the FURS. The level of IL-10 (p = 0.615) and MCP-1 (p = 0.859) did not change significantly after the procedure. There was a decreasing trend of the level of MIP-1α (p = 0.357).

Dr. Hughes concluded that there was changes to inflammatory markers such as VGEF and IL-6 concentrations after the FURS. It is important to analyze such inflammatory markers in a larger cohort to support the prediction or identification of post-operative complications. 

Presented by: Stephen Hughes

Authors: Stephen Hughes, Alyson Moyes, Iqbal Shergill
Affiliation: North Wales & North West Urological Research Center, Wrexham Maelor Hospital, North Wales, UK; Department of Biological Sciences, University of Chester, UK; School of Medical Sciences, Bangor University, North Wales, UK; Department of Urology Betsi Cadwaladr University Health Board, Wrexham Maelor Hospital, North Wales, UK. 

Written by: Long Hoang, Department of Urology, University of California-Irvine at 35th World Congress of Endourology– September 12-16, 2017, Vancouver, Canada.