WCE 2018: What is the Impact of Ureteral Access Sheath Size on Acute Kidney Injury Biomarkers in Retrograde Intrarenal Surgery: A Prospective, Randomized Study

Paris, France (UroToday.com) Ureteral access sheaths (UAS) have been shown to provide adequate ureteral dilation and a working channel for ureteroscopy. They are increasingly being utilized at various centers. Many different UAS exist on the market currently coming in various sizes and characteristics. During, Dr. Tuncel’s moderated poster session, he talked about whether using different UAS during retrograde intrarenal surgery (RIRS), has any effect on protecting kidney function. They evaluated this by measuring various kidney biomarkers including: urinary kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), and N-Acetyl Beta- D-Glucosaminidase (NAG).

In his study, they recruited 54 patients who underwent RIRS that were randomized into either 9.5 Fr UAS or a 12 Fr UAS. For these patients, urine samples were taken right before the procedure, 2 hours after and 24 hours after the procedure. With these samples, the researchers measured the various kidney injury markers aforementioned. Regarding their demographic data, the results were similar between group 1 and 2 (Table below). And, regarding the basal levels of the urine biomarkers, only KIM-1 was higher in group 2 with the others being similar in both groups. 

UroToday WCE2018 Ureteral Access Sheath Size on Acute Kidney Injury Biomarkers

When looking at urinary biomarkers alterations, there was no significant difference in group 1; but in group 2, all urinary biomarkers were significantly increased postoperatively after the procedure. (table below)

UroToday WCE2018 Ureteral Access Sheath Size on Acute Kidney Injury Biomarkers 2

Dr. Tuncel concluded that from their study the kidney biomarkers were increased 2 hours after the procedure for patients who received thicker sized UAS. From these results, he recommended that thin UAS be preferred over thick UAS. A member of the audience began to argue against UAS, in general, saying that sometimes procedures may be done even without thin UAS and complications can be prevented altogether. 


Presented by: Altug Tuncel, MD, University of Health Sciences, Ankara Numune Research and Training Center
Authors: Can Aykanat, Melih Balci, Kilinckaya Muhammed, Seref Coser, Ali Ozercan, Serkan Akdemir, Ozer Guzel, Murat Arslan, Turan Turhan, Yilmaz Aslan
Affiliation: University of Health Sciences, Ankara Numune Research and Training Center

Written by: John Sung, @JohnM_Sung, Department of Urology, University of California-Irvine, medical writer for UroToday.com at the 36th World Congress of Endourology (WCE) and SWL - September 20-23, 2018 Paris, France