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TAT-11: Development and Validation of Methods for Quantitative In Vivo SPECT of Pb-212

Ottawa, ON, Canada (UroToday.com) Pb212 is an interesting isotope targeted alpha therapy, but it is difficult to image using gamma spectrometers. This study seeks to optimize a QSPEC instrument by modeling the data from a phantom to qualitatively understand the various imaging-degrading effects including gamma scattering both in and external to the collimators. The spectrometer used a medium energy collimator and windows of 67-91 keV and 220-257 keV to optimize signal-to-noise. The basic reconstruction scheme was iterative—using the acquired image to generate an attenuation/scattering matrix then reconstructing the original image from the matrix and iterating to sharpen the reconstructed image. The process converged after only a few iterations.


Presented by: Mr. Eric Frey, Radiopharmaceuticals Imaging and Dosimetry