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TAT-11: Optimization of Dosimeter Alpha Therapy: Microlocalisation of Radium-223 in Mouse Models of Metastasis from Prostate Cancer and Renal Cell Carcinoma

Ottawa, ON, Canada (UroToday.com) Dr. Benedallah reported on the micro-distribution of Radium-223 in mice with osteoblastic (typical of prostate cancer metastasis) tumors and with osteolytic (renal cell carcinoma) tumors. Healthy mice were used as controls. The mice were injected with 30 KBq of Radium-223 and sacrificed at 15 min, 4, 24, and 48 hours. Macrodistribution in organs was measured with gamma counting. Sections of the tibia were measured with autoradiography to determine the microdistribution. Macrodistribution showed uptake in the kidneys and, bone but there was little difference in uptake between healthy and diseased tibias. The autoradiograph showed that Radium-223 does not accumulate directly in either type of tumor but rather accumulates in the bone surface around the tumor.


Presented by: Nadia Benabdallah, MD, Institute for Radiological Protection and Nuclear Safety