TAT-11: Various Chromatographic Schemes for Separation of 213Bi from Ac-2.25

Ottawa, ON, Canada (UroToday.com) Dr. Vasiliev described two techniques for Bi223/Ac225 separation at the Institute for nuclear research at the Russian Academy of Science. Each is based on ion exchange in chromatograph resins. In the “direct” method, Ac225 is retained while the accumulated Bi223 from Fr decay is removed by a second sorbent.

In the "inverse" method, the Bi223 is removed by selective absorption from the Ac225 solution and then desorbed for further use. The direct method is more convenient for clinical application, but the admixture of Ac227 may be a problem. Further purification is possible. The yields are limited not only by Ac225 production rate but also by radiation damage to the sorbent resins.


Presented by: Aleksandr Vasiliev, PhD, Institute for Nuclear Research of Russian Academy of Sciences, Moscow, Russia

Written by: William Carithers, Lawrence Berkeley National Laboratory at the 11th International Symposium on Targeted Alpha Therapy (TAT-10)  April 1 - April 4, 2019 - Ottawa, ON, Canada