TAT-11: New Bifunctional Chelators for Ac-225 and 227Th Radioimmunotherapy

Ottawa, ON, Canada (UroToday.com) Ms. Li discussed three chelators developed at their lab: H4octapa(N4O4), H4pypa(N5O4) and H4py4pa(N7O4). Although they are primarily interested in chelation to Ac225 and Th227, because of a lack of stable actinides, they used Lanthanum as an analog to study the chelation geometric properties with NMR spectroscopySignificantig differences in symmetry were observed for the studied chelates.

Returning to Ac and Th, H4py4pa seems to work better for Th227 while all three seem to work well with Ac225, although H4pypa required a higher concentration to achieve a good yield.


Presented by: Ms. Lily Li, Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada

Written by: William Carithers, Lawrence Berkeley National Laboratory at the 11th International Symposium on Targeted Alpha Therapy (TAT-10)  April 1 - April 4, 2019 - Ottawa, ON, Canada