This study looks at the use of small liposomes attached to Ac225. The liposome diffusively penetrates the tumor. The Ac225 is released in the high-pH environment of the tumor interior. In an HER2-negative mouse model, interstitially-releasing 225Ac-loaded liposomes resulted in the longest overall and median survival.
Presented by: Professor Stavroula Sofou, Associate Professor, Chemical and Biochemical Engineering, Rutgers University, Piscataway, New Jersey, United States
Written by: William Carithers, Lawrence Berkeley National Laboratory at the 11th International Symposium on Targeted Alpha Therapy (TAT-10) April 1 - April 4, 2019 - Ottawa, ON, Canada