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TAT-11: PET Imaging of DNA Damage Response following Ac-225-Radioimmunotherapy in a Pancreatic Ductal Adenocarcinoma Mouse Model

Ottawa, ON, Canada (UroToday.com) This study is designed to investigate DNA repair following targeted alpha therapy. Mice with CAi9,9 tumors were treated with a single injection of Ac225-DOTA-5B1 at a dose of 37 kBq. DNA damage imaging was performed using F18 - PArP1 associated with single-strand breaks and Zr89-YH2AX for double breaks.

Imaging scans were performed at 4 hr, 24 hr, and 72 hr after injection. For the single break protein, there was no contrast with the control sample. The double stand protein uptake was significantly higher than the control sample. DNA repair scans show promise for monitoring targeted alpha therapy.


Presented by: Sophie Poty, MD, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, United States

Written by: William Carithers, Lawrence Berkeley National Laboratory at the 11th International Symposium on Targeted Alpha Therapy (TAT-10)  April 1 - April 4, 2019 - Ottawa, ON, Canada