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TAT-11: Contribution of Targeted and Off-target Effects During Radionuclide Therapy Using High-LET Particles

Ottawa, ON, Canada (UroToday.com) Dr. Pouget’s talk covered the so-called “bystander” effect, wherein up to 30% of the damage in radioisotope therapy occurs in cells far removed from the site of the radiation target. This effect is fairly constant and has been observed in many studies. Dr, Pouget discussed the effect of "lipid raft,", a platform of lipids on the surface of the cell membrane. Lipid rafts formation triggers both targeted and bystander effects in alpha radiation efficacy. Patients undergoing treatment to modify lipid metabolism might respond differently to radioisotope therapy.

Bystander effects were studied in vitro by first irradiating cells, then removing the irradiation and damaged cells. The remaining cells were designated donor cells. New cells (recipient) cells were next introduced and could interact with the donor cells. The recipient cells showed cytotoxic effects—the bystander effect;

Dr. Pouget noted that the bystander effect is a good thing to compensate for the heterogeneity of radioactive uptake and the inability to reach the core of the tumor due to its short range.

Act225 Pre-clinical


Presented by Jean-Pierre Pouget, PhD, Head, Radiobiology and Targeted Radiotherapy Team, Institute de Recherche en Cancérologie de Montpellier