In conventional systems a BioRad MP50 cation-exchange resin in a chromatographic column is used to produce Bi213. In this study a micro-fluidic device is loaded with the same MP50 (50-70 microns) an of total volume 10-100 microliters. When loaded with microCi to mCi of Ac225, Bi213 could be extracted with a yield of ~75% with a breakthrough Ac225 contamination of ~0.002%. Future work will investigate the on-chip labeling and separation of labeled antibody from free Bi213.
Presented By: Sandra M. Davern from Nuclear Security and Isotope Technology Division, Oak Ridge National Laboratory, Oak Ridge, TN
Written By: William Carithers, Lawrence Berkeley National Laboratory
at the 10th International Symposium on Targeted Alpha Therapy (TAT-10) May 31 - June 1, 2017 - Kanazawa, Japan.