SUO 2017: Do African American Men Have A Higher Rate Of Discontinuation On Active Surveillance?

Washington, DC (UroToday.com) Introduction: In this study the authors aimed to compare the discontinuation rates of African American (AA) men with Prostate Cancer (PCa) on Active Surveillance (AS) to age and Gleason matched controls.

Methods: For the purpose of this study, the authors retrospectively identified 33 AA men with PCa on AS at their institution. These men were matched by age and Gleason score to 33 Caucasian men with PCa on AS. The discontinuation rates of the two groups were calculated, and associated characteristics were analyzed. A Kaplan-Meier curve was used to compare the overall survival.

Results: 11 (33.3%) of the AA men on AS discontinued compared to 2 (6.0%) of men in the control group. The median time to failure for the AA men was 20 months compared to 29.5 months in the control group. 7 (63.6%) of the AA and 2 (100%) of the control group discontinued due to biopsy progression. The remaining 4 AA men discontinued due to MRI progression (18.2%)
and rising PSA (18.2%). Following AS discontinuation, 5 AA men received radiation, 2 received radical prostatectomy, 3 received cryotherapy and 1 received hormones. The 2 control patients received radiation following AS.

Conclusion: Although this is a relatively small cohort, the authors concluded that AA men have higher discontinuation rates of AS, when compared to age and Gleason matched controls. This finding suggests might suggest a possible need for alternative protocol for AA men on surveillance.

Presented by: Aaron Edward Katz, NYU Winthrop Hospital Mineola NY, USA

Written by: Hanan Goldberg, MD, Urologic Oncology Fellow (SUO), University of Toronto, Princess Margaret Cancer Centre, @GoldbergHanan, at the 18th Annual Meeting of the Society of Urologic Oncology, November 29-December 1, 2017 – Washington, DC
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