SUFU 2018: Safety and Efficacy of Onabotulinumtoxina Injections in Octo and Nonagenarians

Austin, TX ( Dr. Patricia Zahner presented a retrospective case series comparing patients undergoing intravesical botox injections (BTX-A) for the treatment of overactive bladder (OAB). 62 patients were ages 80-94 years versus 68 patients ages 50-70.  They examined demographics, complications, and clinical characteristics of the two groups.

The elderly group had a complication rate of 23% and the younger group 16% (p=0.36).  Rates of urinary retention were seen more frequently in the elderly group, reported at 11% versus 4% in the younger cohort (p=0.14).  UTI was similar between the two groups, 6% in the elderly and 7% in the younger group (p=0.84). The most common complication seen in the elderly group was urinary retention and for the younger, it was UTI.  Satisfaction rates were similar, 47% reported from the elderly cohort and 53% in the younger group (p=0.31).  Regardless of age, the patients were more severe comorbidities had a higher risk for re-hospitalization, compared with those with none (OR:16.1, p=0.03).

The authors present a study which demonstrated that complication rates for intravesical botox injections are similar, across age groups.  This will serve to help counsel patients when deciding on third line treatment option for refractory OAB.

Presented by: Patricia Zahner, MD

Authors: Patricia M. Zahner , Laura L. Giusto MD, Jessica C. Lloyd MD, Juan M. Guzman-Negron MD, Shree Agrawal BS, Courtenay K. Moore MD, Raymond R. Rackley MD, Sandip P. Vasavada MD and Howard B. Goldman MD, Cleveland Clinic, Cleveland, Ohio

Written by: Cristina Palmer, DO. Female Urology, Pelvic Reconstruction, Voiding Dysfunction Fellow, Department of Urology, UC Irvine Medical Center, Orange, California at the Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction Winter Meeting (SUFU 2018), February 27-March 3, 2018, Austin, Texas

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