SIU 2017: Novel Classification of Gleason 7 Prostate Cancer According to the Discrepancy between Biopsy and Final Gleason Score after Radical Prostatectomy

Lisbon, Portugal ( This study, presented by Dr. Cho, evaluated the impact of pathological upgrading of Gleason score 7 prostate cancer on the risk of biochemical recurrence after radical prostatectomy (RP).

A total of 1678 consecutive patients who had biopsy proven prostate cancer and underwent RP with postoperative Gleason score (GS) of 7 were retrospectively reviewed. The patients were then divided into 4 groups: 

1. upgraded GS 3+4
2. non-upgraded GS 3+4
3. upgraded GS 4+3
4. non-upgraded GS 4+3

Kaplan-Meier survival curve and multivariable models were developed to examine the influence of pathological upgrading of GS 7 on the risk of biochemical recurrence.

Mean age of the non-upgraded GS 4+3 was significantly higher than other groups. Five year biochemical recurrence free survival rate was 85%, 73%, 69% and 60% in the 4 groups, respectively. No significant difference was found between group 2 and group 3.

The authors concluded that that the information on pathologic upgrading could help provide more detailed information on the risk of biochemical recurrence in GS 7 disease.

Presented by: Cho MH
Affiliation: Medical Center, Seoul, South Korea

Written by: Hanan Goldberg, MD, Urologic Oncology Fellow (SUO), University of Toronto, Princess Margaret Cancer Centre.Twitter: @GoldbergHanan at the 37th Congress of Société Internationale d’Urologie - October 19-22, 2017- Lisbon, Portugal


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