FREE DAILY AND WEEKLY NEWSLETTERS OFFERED BY CONTENT OF INTEREST
Did you find this article relevant? Subscribe to UroToday-GUOncToday!
The fields of GU Oncology and Urology are advancing rapidly including new treatments, enrolling clinical trials, screening and surveillance recommendations along with updated guidelines. Join us as one of our subscribers who rely on UroToday as their must-read source for the latest news and data on drugs. Sign up today for blogs, video conversations, conference highlights and abstracts from peer-review publications by disease and condition delivered to your inbox and read on the go.
Based on data from the Cancer Registry of Norway (CRN) and the Norwegian Prostate Cancer Registry (NoPCR), the authors identified 1,642 patients diagnosed with PCa between 2001 and 2005, who underwent RP within 6 months of diagnosis. None of the patients had known metastatic disease. Patients were stratified according to EAU contemporary risk groups (low, intermediate, high) and time interval from diagnosis to RP (≤60, 61-90, 91-120, 121-180 days). The time interval ≤60 days corresponded to the estimated time from the first cancer positive biopsy to RP performed within the time limit defined by the fast-track system. PCSM was calculated using Kaplan-Meier estimates, based on a median observation time of 12 years (range 0-16).
The median age of patients was 61 years (39-76). A total of 24%, 36% and 41% of patients had low-, intermediate- and high-risk disease, respectively. Two hundred ninety-two (18%), 556 (34%), 414 (25%) and 380 (23%) patients were treated with RP ≤60, 61-90, 91-120, and 121-180 days from diagnosis, respectively. No statistically significant association was found between the duration of the RP-interval and PCSM in any risk group. For patients in the high-risk group with RP-intervals of ≤60, 61-90, 91-120, and 121-180 days, the PCSM was respectively 18.5% (CI 0- 38.5), 4.7% (CI 1.3-8.1), 1.6% (0-4.8) and 3.1% (0-6.3), respectively.
The authors concluded, that the time interval from diagnosis to primary RP performed within 180 days of diagnosis did not affect PCSM in any risk group at a median follow-up of 12 years. The authors concluded that patients and physicians should be aware of these data when prostatectomy is planned.
Presented by: Aas K, Oslo University Hospital, Dept. of Surgery, Oslo, Norway
Written by: Hanan Goldberg, MD, Urologic Oncology Fellow (SUO), University of Toronto, Princess Margaret Cancer Centre, twitter: @GoldbergHanan at the 2018 European Association of Urology Meeting EAU18, 16-20 March, 2018 Copenhagen, Denmark