The study was conducted as a secondary analysis of the ProtecT trial. A total of 4,329 men had a positive first degree family history of prostate cancer. From this group, 571 had a PSA level ≥ 3 ng/ml. Two hundred thirty-four tumors (5.4%) were detected in patients with a positive first degree family history of prostate cancer. The detection rate among the remaining 69,234 men without a family history of prostate cancer was 3.7%. Men with a positive family history had an increased risk of prostate cancer (RR 1.47, 95% CI 1.28-1.68). This was most pronounced in men with an affected brother (RR 2.49, 95% CI 1.41-3.02) and those with an affected relative less than 60 years of age (RR 1.65, 95% CI 1.33-2.05).
The authors concluded that men in their 50s and 60s with a first-degree family history have an increased risk of developing prostate cancer. These men should be counselled appropriately regarding this risk when considering a biopsy.
Presented by: T. J. Johnston, University of Bristol and University of Cambridge, England
Written by: Benjamin T. Ristau, MD, SUO Fellow, Fox Chase Cancer Center, Philadelphia, PA.
at the #EAU17 -March 24-28, 2017- London, England