EAU 2017: Comparing 20,000 open prostatectomy (RRP) cases to 5,000 robotic prostatectomy (RALP) cases, he noted no differences in oncologic outcome or urinary continence

London, England (UroToday.com) Screening strategies for prostate cancer are changing from a population-wide screening strategy to more selective algorithms that preferentially identify clinically significant prostate cancer. The present study sought to determine the effect of family history of prostate cancer on a population-based screening program.

The study was conducted as a secondary analysis of the ProtecT trial. A total of 4,329 men had a positive first degree family history of prostate cancer. From this group, 571 had a PSA level ≥ 3 ng/ml. Two hundred thirty-four tumors (5.4%) were detected in patients with a positive first degree family history of prostate cancer. The detection rate among the remaining 69,234 men without a family history of prostate cancer was 3.7%. Men with a positive family history had an increased risk of prostate cancer (RR 1.47, 95% CI 1.28-1.68). This was most pronounced in men with an affected brother (RR 2.49, 95% CI 1.41-3.02) and those with an affected relative less than 60 years of age (RR 1.65, 95% CI 1.33-2.05).

The authors concluded that men in their 50s and 60s with a first-degree family history have an increased risk of developing prostate cancer. These men should be counselled appropriately regarding this risk when considering a biopsy.

Presented by: T. J. Johnston, University of Bristol and University of Cambridge, England

Written by: Benjamin T. Ristau, MD, SUO Fellow, Fox Chase Cancer Center, Philadelphia, PA.

at the #EAU17 -March 24-28, 2017- London, England