In the whole cohort On-C patients were significantly younger (p=0.001), less frequently smokers (p=0.01), with a lower incidence of diabetes (p=0.001) and hypertension (p=0.001), lower ASA scores (p25% in the first 8-yr follow-up (p=0.02). The probability of developing a CKD stage 3b was significantly higher (log rank p=0.006) in the On-C cohort (2, 5 and 8yr risk 0.9%, 5.1% and 12.8% versus 0.6%, 1.2% and 1.2% in the Off-C cohort, respectively. At multivariable Cox regression analysis, eGFR at discharge (HR 0.94; 95% CIs 0.91-0.98, p=0.002) and Off-clamp approach (HR 7.33; 95% CIs 1.8-29.4, p=0.005) were independent predictors of improved renal functional outcomes.
In conclusion, Off-C PN is associated with a significantly higher probability of maintaining 100% eGFR after surgery compared with On-C PN in patients with cT1-2/N0/MO renal tumors and good baseline renal function. Patients treated with On-C PN had a 7.3 fold increased risk of developing a severe CKD during follow-up.
Presented by: Giuseppe Simone, Rome, Italy
Written by: Hanan Goldberg, MD, Urologic Oncology Fellow (SUO), University of Toronto, Princess Margaret Cancer Centre @GoldbergHanan at the 2018 AUA Annual Meeting - May 18 - 21, 2018 – San Francisco, CA USA