AUA 2018: Estrogen Receptor β Promotes Renal Cell Carcinoma Progression via Regulating LncRNA HOTAIR-miR-138/200c/204/217 Associated CeRNA Network
San Francisco, CA USA (UroToday.com)The relationship between the estrogen receptor and many known hormone-sensitive tumors has been identified, but the relationship of that and renal tumors has not been clearly observed. This clinical study presented by Jie Ding, MD, a urology specialist of the University of Rochester Medical Center, composed of the effect of over expressions and knockout of the estrogen receptor beta and the survival rate of patients with RCC. Although there was already identification between the regulatory relationship between the alpha and beta receptor,
AUA 2018: Use of Urinary Metabolomics to Identify High-Risk Clear Cell Renal Cell Carcinoma
San Francisco, CA USA (UroToday.com) Mohit Gupta, MD, a urologic oncologist at John Hopkins University of Medicine, presented a study regarding metabolomic markers that may identify and differentiate high-risk clear cell RCC from benign tumors. Dr. Gupta began the presentation by introducing the importance of metabolomics to identify discrepancies within current pathways known to urologic oncology. Although these pathways have been studied and used for different types of cancers, specific markers within urine of patients with ccRCC have not been clearly identified.
AUA 2018: The More You See, The More You Miss: Association Between PI-RADS Score of the Index Lesion and Multi-Focal, Clinically Significant Prostate Cancer
San Francisco, CA (UroToday.com) An extremely important consequence of our growing comfort with MRI-fusion targeted prostate biopsies is that systematic biopsies appear to be less important in some men. The results of the recent PRECISION trial, in fact, show that targeted biopsies alone may be a suitable way to detect clinically significant prostate cancer (csPC) in men undergoing diagnostic biopsies. The question lingers, though, about how much these targeted biopsies are potentially missing.
AUA 2018: Multi-Institutional External Validation of the EAU Guidelines for the Use of Staging mpMRI Prior to Radical Prostatectomy in Men with Intermediate and High-Risk Prostate Cancer
San Francisco, CA (UroToday.com) Current EAU guidelines advocate for the use of mpMRI for patients with high risk disease (defined as high risk on D’Amico criteria or >=ISUP Grade 3) for local staging purposes. These recommendations are based on evidence that has not previously been externally validated, though. The presenters, therefore, used a 4-institutional cohort of men in Europe to evaluate the utility of mpMRI for these high-risk men in a real-world setting.
AUA 2018: Association of Systematic Biopsy vs. Magnetic Resonance Imaging/Ultrasound Fusion Targeted Biopsy with Prostate Cancer Upstaging at Radical Prostatectomy
San Francisco, CA (UroToday.com) Multiparametric prostate MRI (mpMRI) has clear utility for many aspects of prostate cancer diagnosis, staging, and preoperative planning. However, given that it is a relatively newly-adopted modality, little is known regarding how mpMRI might predict downstream outcomes for patients undergoing treatment for prostate cancer.
AUA 2018: Evaluation of Gallium-68 PSMA PET/CT Imaging in Individuals with Biochemical Recurrence Following Radical Prostatectomy
San Francisco, CA (UroToday.com) Ga-68 PSMA PET is growingly seen as one of the most important breakthroughs in prostate cancer imaging over the past decade. Its ability to detect metastatic disease that was previously invisible to conventional CT and bone scan imaging makes it a very attractive imaging modality for both clinical and research use.
AUA 2018: Local Immune Modulation by Decreasing CD4+/CD8+ T Cells Ratio after Prostate Cancer Hemi-Cryoablation
San Francisco, CA (UroToday.com) Leonardo Reis MD, and colleagues sought to answer a unique question with regard to the effect of thermal ablation on prostate immune infiltrates following therapy. Thermal ablation is known to increase antigen presentation, thereby possibly activing tumor-specific T cells, but little is known about the immune response within the local prostatic environment.