AUA 2016: Predictive factors of Stone Formation in Primary Hyperparathyroidism Patients - Poster Session Highlights

San Diego, CA USA ( In the general population, nephrolithiasis is a common disease. Hypercalciuria is a primary risk factor for stones, while primary hyperparathyroidism (PHPT) is a risk factor for nephrolithiasis. Since there is a 2-8% rate of concurrent PHPT in nephrolithiasis patients, Dr. Doizi and colleagues aim to determine the predictive factors for patients that are stone formers (SF) with PHPT, as opposed to the non-stone formers. (NSF)

In this retrospective study with 177 PHPT patients (99 SF and 78 NSF), the authors looked at patients with biochemical evidence of PHPT, as indicated by hypercalcemia (<10.2 mg/dL) with high serum parathyroid hormone (PTH) without secondary causes of parathyroid stimulation. The study involved analysis of serum parameters, such as: calcium, phosphorus, PHT and eGFR. Urinary parameters included: Calcium, sodium, creatinine and total volume. When looking at 24-hour urinary calcium levels, the SF group was significantly elevated. There were also significantly higher levels of urinary creatinine and sodium in the SF group. In the SF group, there was also a significant correlation in non-African Americans, a younger age category, as well as a significantly higher proportion of men.

The authors concluded that younger patients, high urinary calcium and sodium, and non-African American ethnicity were predictive factors for PHPT.


Presented By: Steve Doizi, MD

Written By: Victor Huynh, CCRP, Department of Urology, University of California, Irvine at the 2016 AUA Annual Meeting - May 6 - 10, 2016 – San Diego, California, USA