Dr. Rahul Aggarwal presented a study where newly diagnosed or biochemically recurrent (BCR) PC patients with apparent localized disease on standard imaging, were enrolled. This was a prospective study where all patients underwent 68Ga-PSMA PET imaging between June 2015 and January 2017 and were analyzed for incidence of IT metastasis (Clinical trial information: NCT02918357). Positive lesions were defined as uptake higher than blood pool. When appropriate, patients underwent confirmatory biopsy of the PSMA-avid IT lesions. This study’s objectives were to estimate the incidence of IT metastasis in the setting of newly diagnosed and BCR state; and to ascertain the long term clinical outcomes of patients with IT metastasis versus those without.
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In summary, IT metastasis was found in 5.5% of patients. Higher serum PSA at time of imaging was associated with detection of IT metastasis. Further studies are warranted to validate these findings and determine the optimal strategy for the detection and treatment of IT metastases in newly diagnosed and biochemically recurrent PC.
Presented By: Rahul Raj Aggarwal, MD, University of California San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, CA
Written By: Hanan Goldberg, MD, Urologic Oncology Fellow (SUO), University of Toronto, Princess Margaret Cancer Centre, Toronto, Ontario, Canada
at the 2017 ASCO Annual Meeting - June 2 - 6, 2017 - Chicago, Illinois, USA