IBCN 2018: Mismatch Repair Deficiency in Upper Tract and Bladder Urothelial Carcinoma
Rotterdam, The Netherlands (UroToday.com) Joost L. Boormans discussed a clinical trial concept regarding mismatch repair deficiency in upper tract and bladder urothelial carcinoma. Lynch syndrome predisposes to upper tract urothelial carcinoma (UTUC) which is the 3rd most common cancer among patients with this syndrome.
IBCN 2018: Influence of Intra-Tumor Heterogeneity on the Molecular Classification of Bladder Cancer
Rotterdam, The Netherlands (UroToday.com) Gottfrid Sjödahl presented influence of intra-tumor heterogeneity on the molecular classification of bladder cancer. Potential issues include where tumor assessed including site and type of resection including transurethral versus cystectomy specimens. Out of 21 solid tumor sites, bladder was the 5th less pure tumors highlighting tumor heterogeneity.