EAU 2018

EAU 2018: Who are the Optimal Candidates for Bladder Preservation in Cases of Muscle Invasive Bladder Cancer?

Copenhagen, Denmark (UroToday.com)  Dr. Van der Heijden discussed which patients with muscle invasive bladder cancer (MIBC) are optimal candidates for bladder preservation. Dr. Van der Heijden started by making it clear that the EAU guidelines on MIBC state that the preferred recommendation is for radical cystectomy and urinary diversion. However, there is precedent for organ preservation in other malignancies, including breast cancer, kidney cancer, prostate cancer, and anal cancer. 

EAU 2018: Utility of Lymph Node Dissection for Clinical Node Negative Upper Tract Urothelial Cell Carcinoma: A Multicenter Study

Copenhagen, Denmark (UroToday.com)  Dr. Derweesh from UC San Diego discussed results of a multi-center study evaluating clinical node negative UTUC lymphadenectomy. Although the use of a lymph node dissection for urothelial cell carcinoma of the bladder has survival benefit even in setting of negative nodal status, therapeutic benefit of LND in the setting of clinical node negative disease for UTUC is unclear. The objective of this study was to evaluate survival outcomes for UTUC after lymphadenectomy.

EAU 2018: 4D Ultrasound Cystoscopy with Fly Through in the Evaluation of Urinary Bladder Tumors: Feasibility and Outcomes

Copenhagen, Denmark (UroToday.com)  Dr. Grande and colleagues from Italy discussed their experience with 4D ultrasound cystoscopy with Fly Thru. Cystoscopy represents the gold standard both for the diagnosis and the surveillance of patients treated conservatively for bladder cancer. To date, a reliable, non-invasive, imaging method for bladder cancer detection has yet to be established and follow-up is based on regular cystoscopy. The recently introduced Fly Thru technology virtually travels through a body cavity and produces endoscopic images from outside the body. This provides the opportunity to assess masses and plan for appropriate management. 

EAU 2018: Latent Viral Infection as a Factor of Unfavorable Prognosis of Bladder Cancer

Copenhagen, Denmark (UroToday.com)  The concept of human malignancy being solely driven by viral infection has long since been disproven. However, there is strong evidence that viral infection is associated with malignancy in many different cancer types. While such association has not been established in the setting of bladder cancer, the authors investigate the possible relationship between viral infection and bladder cancer, and whether the long-term persistence of the virus in the body is necessary for tumorigenesis.

EAU 2018 - Prostate Specific Antigen (PSA) Response in Men With Nonmetastatic Castration-Resistant Prostate Cancer (M0 CRPC) Treated With Enzalutamide: Results From PROSPER

Copenhagen, Denmark (UroToday.com) M0 CRPC or nmCRPC is an area of unmet need. Development of metastases is associated with increasing baseline PSA and PSA doubling time <10 months. 2-3  Median metastasis-free survival (MFS) was 25-30 months in the placebo arms of several randomized controlled trials.1-3  Delaying time to all metastases is clinically relevant, with potential to delay cancer-related morbidity and prolong overall survival (OS). Enzalutimide significantly improved OS and radiographic progression-free survival (rPFS) in men with chemotherapy-naive M1 CRPC in the phase 3 PREVAIL study. 5 Enzalutimide was superior to bicalutamide in improving rPFS in the subgroup of patients with chemotherapy-naive M0 CRPC in the phase 2 STRIVE study. 6 We hypothesized that enzalutimide will delay metastases development in men with M0 CRPC and rapidly rising PSA (PSA doubling time 2265≤ 10 months). 

EAU 2018: Challenges in Flexible Endoscopy

Copenhagen, Denmark (UroToday.com)  Dr. Seitz started off the thematic session on “Challenges in Upper Urinary Tract Urothelial Cancer” with challenges in flexible endoscopy. Upper Urinary Tract Urothelial Carcinoma (UTUC) remains a challenge to manage due to the relative rarity of the disease, the difficulties with tissue acquisition and imaging, and difficulties with reliable staging.

EAU 2018: European Society of Urogenital Radiology Lecture: Challenges in Imaging of UTUC

Copenhagen, Denmark (UroToday.com)  Dr. Cowan was the guest speaker for the ESUR lecture and focused on challenges in the imaging of urinary tract urothelial cancer (UTUC). He broke down the challenges that face us into 3 categories: those that relate to the disease, those that related to the urologist and radiologist and those that relate to the radiologist alone.