AUA 2018: Is PSA Density Useful in Predicting Low-Risk Prostate Cancer in African American Men?
San Francisco, CA (UroToday.com) In African-American (AA) men the incidence of prostate cancer is almost 60% higher, and the mortality rate is two- to three-times greater than that of Caucasian men. Over the last 10 years, there has been a significant push to offer active surveillance to patients who are diagnosed with low-risk prostate cancer. PSA density (PSAD) has been one of the main criteria utilized to help differentiate patients at low risk for prostate cancer progression. The current recommendation is that patients with group 1 disease (Gleason 3+3=6) and a PSADT < 0.15 ng/ml/gm have a low potential for prostate cancer progression. However, this value was derived from historical cohorts of mostly Caucasian (CA) men, and the PSAD remains to be validated in an AA cohort. Dr. Babaian, from LSU Shreveport, presents data validating the role of PSAD in identifying men with low-risk prostate cancer.
AUA 2018: The National Resident Matching Program Code of Conduct: What Is The Degree Of Compliance During The Urology Match Process?
San Francisco, CA USA (UroToday.com) Elisabeth Sebesta, MD, a clinical urologist from New York, NY, presented on a study that assessed the frequency and type of violations to NRMP Code of Conduct and Urology Match “guidelines to programs” statement during the Urology Match process in conjunction with the applicants’ perception of these violations.
AUA 2018: Learning Curve With The No-Flip Shangring Circumcision in Kenya
San Francisco, CA USA (UroToday.com) Omar Al Hussein Alawamlh, MD, a clinical urologist from New York, NY, presented on a study looking at the learning curve involved with a male circumcision device. Voluntary medical male circumcision (VMMC) has been shown by three large randomized control trials in Africa to decrease HIV incidence in men by 50-60%. Given this, the UNAIDS and WHO have recommended that VMMC be included as part of their HIV prevention strategies. As a result, 14 sub-Saharan African countries have started to scale up male circumcision services.
AUA 2018: Do Patients Undergoing Primary Ureteroscopy for Ureteral Stones Have a Lower Post-Operative Sepsis Rate Compared to Those Previously Stented?
San Francisco, CA USA (UroToday.com) Nina Mikkilineni, a clinical urologist from the Irving Medical Center at Columbia University, discussed her findings on the rates of sepsis following pre-stenting of patients versus primary ureteroscopy (P-URS). To begin, Dr. Mikkilineni advocated that P-URS is preferred over preoperative stenting due to fewer procedures for the patient, lower short-term costs, shorter duration of irritative stent symptoms, and a possible decreased infection risk.
AUA 2018: Treatment of Non-Obstructive Urolithiasis is Effective in Treatment of Recurrent Urinary Tract Infections
San Francisco, CA USA (UroToday.com) Deepak Agarwal, MD, a clinical urologist from the Mayo Clinic in Rochester Minnesota, presents his research on the treatment of non-obstructive urinary calculi to treat recurrent urinary tract infections (UTIs). Patients who present with these two conditions are particularly challenging patients to treat and are associated with a significant morbidity and cost. According to Dr. Agarwal, there has been growing evidence that the surgical removal of these non-obstructing stones may be beneficial to the treatment of recurrent UTIs. Additionally, it has been shown in previous research that kidney stones can be colonized with bacteria despite appropriate antibiotic administration. Therefore, Dr. Agarwal and his team sought to determine whether or not these procedures are effective.
AUA 2018: Estrogen Receptor β Promotes Renal Cell Carcinoma Progression via Regulating LncRNA HOTAIR-miR-138/200c/204/217 Associated CeRNA Network
San Francisco, CA USA (UroToday.com)The relationship between the estrogen receptor and many known hormone-sensitive tumors has been identified, but the relationship of that and renal tumors has not been clearly observed. This clinical study presented by Jie Ding, MD, a urology specialist of the University of Rochester Medical Center, composed of the effect of over expressions and knockout of the estrogen receptor beta and the survival rate of patients with RCC. Although there was already identification between the regulatory relationship between the alpha and beta receptor,
AUA 2018: Use of Urinary Metabolomics to Identify High-Risk Clear Cell Renal Cell Carcinoma
San Francisco, CA USA (UroToday.com) Mohit Gupta, MD, a urologic oncologist at John Hopkins University of Medicine, presented a study regarding metabolomic markers that may identify and differentiate high-risk clear cell RCC from benign tumors. Dr. Gupta began the presentation by introducing the importance of metabolomics to identify discrepancies within current pathways known to urologic oncology. Although these pathways have been studied and used for different types of cancers, specific markers within urine of patients with ccRCC have not been clearly identified.