2019 ASCO GU Symposium

2019 ASCO GU Symposium

INTERVIEW WITH DENA BATTLE
Patient Perspectives on Cytoreductive Nephrectomy after the CARMENA Trial

VIEW ALL ASCO GU 2019 VIDEOS

Prostate Cancer Foundation 2018 Scientific Retreat

Prostate Cancer Foundation 2018 Scientific Retreat

INTERVIEW WITH OLIVER SARTOR
Overall Survival Benefit and Racial Disparities in African American Men with Metastatic Prostate Cancer

VIEW ALL PCF VIDEOS

2019 ASCO GU Symposium

2019 ASCO GU Symposium

INTERVIEW WITH KARIM FIZAZI
ARAMIS - Efficacy and Safety of Darolutamide in nmCRPC

VIEW ALL ASCO GU 2019 VIDEOS

2019 ASCO GU Symposium

2019 ASCO GU Symposium

INTERVIEW WITH JAMES GULLEY
Immunotherapy Across Genitourinary Malignancies

VIEW ALL ASCO GU 2019 VIDEOS

Featured Videos

#AUA14 - Statin use is an independent predictor of improved survival in patients with metastatic renal cell carcinoma - Session Highlights

ORLANDO, FL USA (UroToday.com) - It has been hypothesized that because of their possible effects on the Akt/mTOR pathway, statins may be beneficial for treating cancer. In their presentation, Bishoy Gayed and colleagues discussed their efforts to identify potential association between statin use and outcomes in patients with metastatic renal cell carcinoma (mRCC).

auaThe study was comprised of 63 patients who were treated for mRCC at one institution. They performed a retrospective review of the cases and divided patients based on Motzer criteria. There was a limitation in the methods in that the authors could only identify 11.1% of cases that had available risk data. The authors used Kaplan Meier analysis to evaluate cancer-specific survival.

They reported that 50.8% of their patients had stage of pT3, and 82.4% of the patients had clear cell pathology. When the authors analyzed their results, they found that 54% of their patients had already died of metastatic RCC. Their data showed that patients who used statins had improved cancer-specific survival in a 2-year period.

The authors concluded that statin use was associated with improved survival in patients with metastatic RCC. However, given the study was retrospective, a prospective trial is needed. It is important to have a larger sample to assess the real impact of statins on metastatic renal cell carcinoma. While obesity is also associated with renal cell carcinoma, the authors did not include it as a covariate in their analysis. It would be important in future studies to consider obesity and other potential covariates that may be involved in survival rates of patients in order to draw conclusions from statin use.

Presented by Bishoy Gayed, MD at the American Urological Association (AUA) Annual Meeting- May 16 - 21, 2014 - Orlando, Florida USA

The University of Texas Southwestern Medical Center, Dallas, TX USA

Written by Garen Abedi, MD, University of California (Irvine), and medical writer for UroToday.com

 

Conference Coverage
 
Recent data from conferences worldwide
Journals
Publications focusing on urologic cancer treatments through original manuscripts
Everyday Urology Volume 3 Issue 4

Everyday Urology™ - Oncology Insights

PCAN cover

Prostate Cancer and Prostatic Diseases

From the Editor

E-Newsletters

Newsletter subscription

Free Daily and Weekly newsletters offered by content of interest

The fields of GU Oncology and Urology are rapidly advancing. Sign up today for articles, videos, conference highlights and abstracts from peer-review publications by disease and condition delivered to your inbox and read on the go.

Subscribe