EAU 2014 - Nephron sparing surgery does not decrease other-causes mortality relative to radical nephrectomy in patients with clinical T1a-T1b renal mass: Results from a large multi-institutional study - Session Highlights

STOCKHOLM, SWEDEN (UroToday.com) - In patients with small renal masses, nephron-sparing surgery (NSS) may improve all-cause mortality when compared to radical nephrectomy (RN). However, numerous prior studies attempting to analyze the survival benefit of NSS are plagued by selection bias and the inability to completely control for confounding characteristics. Dr. U. Capitanio and colleagues tested the effect of treatment type (NSS vs RN) on survival following adjustment for clinical characteristics, comorbidities, and individual cardiovascular risk. A total of 2 685 patients, with clinical T1a-T1b renal mass, from 4 tertiary care centers in Europe underwent RN (39.4%) or NSS (60.6%). Among all patients, eGFR was normal prior to surgery.

eauAfter a median follow-up of 61 months, 5- and 10-year other-cause mortality rates after NSS were 5.2% and 13.2% vs 7.4% and 15.1% following RN, respectively. Following multivariable analysis, patients treated with PN showed similar risk to die of other-cause mortality compared with their RN-treated counterparts (HR 0.77). Increasing age (HR 1.1), Charlson Comorbidity Index (HR 1.2), and tobacco use (HR 1.9) were independent predictors of other-cause mortality. Following adjustment for comorbidity and competing risks, NSS does not appear to decrease other-cause mortality relative to RN among the patients examined.

Presented by U. Capitanio at the 29th Annual European Association of Urology (EAU) Congress - April 11 - 15, 2014 - Stockholmsmässan - Stockholm, Sweden.

San Raffaele Scientific Institute, Department of Urology, Milan, Italy

Written by Jeffrey J. Tomaszewski, MD, medical writer for UroToday.com

 

Conference Coverage
 
Recent data from conferences worldwide
  • 2020 Annual Meeting / June 27-28 / AUA Live Virtual Program
  • 2020 Annual Meeting / May 29-31 / Virtual Scientific Program
  • 2020 Winter Meeting / February 25-29 / Scottsdale, AZ
  • 2020 Annual Meeting / February 13-15 / San Francisco, CA
  • 2019 Annual Meeting / December 4-6 / Washington, DC
  • 2019 Annual Congress / October 17 - October 20 / Athens, Greece
  • 2019 Annual Meeting / October 3 - October 5 / Aarhus, Denmark
  • 2019 Annual Congress / September 27 - October 1 / Barcelona, Spain
  • 2019 Biennial Meeting / August 29-31 / Basel, Switzerland
  • 2019 Think Tank / August 8-10 / Washington, DC
  • 2019 Annual Meeting / May 31 - June 6 / Chicago, IL
  • 2019 Annual Meeting / May 3-6 / Chicago, IL