GU Cancers Symposium 2014 - Best of journals: Renal cancer - medical oncology - Session Highlights

SAN FRANCISCO, CA USA (UroToday.com) - Dr. Elisabeth Heath presented the results of two phase III trials in the context of a 68-year-old healthy male who presented with a large renal mass without evidence of metastasis.

He underwent nephrectomy but developed pulmonary metastases 16 months later. Combination therapy for metastatic renal cell carcinoma has generated much interest after the demonstration of activity for Interferon-alfa/bevacizumab. The INTORACT trial compared this regimen to Interferon-alfa/temsirolimus in 791 patients, and, unfortunately, showed no difference in the primary endpoint (progression free survival) or overall survival. Additional subgroup analysis did not show that any particular groups benefited from either arm. gucancerssympalt thumbHowever, the Interferon-alfa/temsirolimus arm had a significantly higher rate of toxicity. Based on the result of this trial, the patient received Interferon-alfa/bevacizumab. Nine months later the patient had radiographic progression, which prompted a treatment change. In this setting, one might wonder if treatment with another antiangiogenic agent is useful if the patient failed prior antiangiogenic therapy. The INTERSECT trial sought to help answer this debate by comparing temsirolimus and sorafenib in 512 patients who progressed on first-line sunitinib. Again, no difference in the primary outcome (progression-free survival) was demonstrated. However, overall survival was increased in patients receiving sorafenib, and subgroup analysis showed that clear cell renal cell carcinoma, cytoreductive nephrectomy, and a longer interval on sunitinib prior to progression benefitted as well. INTERSECT also showed that there was higher toxicity with temsirolimus.

 

Highlights of a presentation by Elisabeth Heath, MD at the 2014 Genitourinary Cancers Symposium - January 30 - February 1, 2014 - San Francisco Marriott Marquis - San Francisco, California USA

Karmanos Cancer Center, Detroit, MI USA

Written by Phillip Abbosh, MD, PhD, medical writer for UroToday.com


View Full 2014 GU Cancers Symposium Coverage

 

Conference Coverage
 
Recent data from conferences worldwide
  • 2020 Virtual Annual Meeting / Nov 13-14
  • 2020 Annual Virtual Meeting / Oct 17
  • 2020 Annual Congress / October 10 - 11
  • 2020 Annual Meeting / October 1-3
  • 2020 Virtual Congress / September 19-21
  • 2020 BCAN Think Tank Virtual / August 7
  • 2020 Virtual Education Program / August 8-10
  • 2020 Annual Meeting / July 17-19 / EAU Virtual Program
  • SUO - AUA 2020 Summer Webcast / July 18
  • 2020 Annual Meeting / June 27-28 / AUA Live Virtual Program
  • 2020 Annual Meeting / May 29-31 / Virtual Scientific Program
  • 2020 Annual Meeting / February 13-15 / San Francisco, CA
  • 2019 Annual Meeting / December 4-6 / Washington, DC
  • 2019 Biennial Meeting / August 29-31 / Basel, Switzerland