GU Cancers Symposium 2014 - A pooled analysis of RTOG 9906 and 0233 - Session Highlights

SAN FRANCISCO, CA USA (UroToday.com) - Dr. Timur Mitin presented an abstract comparing outcomes in complete and near-complete responses (CR and nCR) in bladder preservation protocols.

Previous randomized studies in bladder preservation protocols necessitated a radical cystectomy for patients with residual disease after induction therapy. However, pathological analyses of these specimens showed that many of the patients had minimal residual disease. This prompted the RTOG to determine if such minimal residual disease can be safely managed without cystectomy.

gucancerssympalt thumbDr. Mitin presented the data from RTOG 9906 which was a single-arm prospective trial of bladder preservation with twice daily radiation and radio-sensitizing chemotherapy, and also data from RTOG 0233 which was a randomized controlled trial assessing two different chemotherapy regimens, in addition to radiation. He compared the outcomes of CR (n=101) and nCR (n=18) patients and showed that there was no significant difference in recurrence, muscle-invasive recurrence, salvage cystectomy rates, or overall survival. This suggests that patients with non-muscle invasive disease, after bladder preservation protocols, may be safely observed and managed endoscopically.

Highlights of a presentation by Timur Mitin, MD, PhD at the 2014 Genitourinary Cancers Symposium - January 30 - February 1, 2014 - San Francisco Marriott Marquis - San Francisco, California USA

Massachusetts General Hospital, Boston, MA USA

Written by Phillip Abbosh, MD, PhD, medical writer for UroToday.com


View Full 2014 GU Cancers Symposium Coverage

 

Conference Coverage
 
Recent data from conferences worldwide
  • 2020 Virtual Congress / September 19-21
  • 2020 BCAN Think Tank Virtual / August 7
  • 2020 Virtual Education Program / August 8-10
  • 2020 Annual Meeting / July 17-19 / EAU Virtual Program
  • SUO - AUA 2020 Summer Webcast / July 18
  • 2020 Annual Meeting / June 27-28 / AUA Live Virtual Program
  • 2020 Annual Meeting / May 29-31 / Virtual Scientific Program
  • 2020 Annual Meeting / February 13-15 / San Francisco, CA
  • 2019 Annual Meeting / December 4-6 / Washington, DC
  • 2019 Annual Meeting / October 3 - October 5 / Aarhus, Denmark
  • 2019 Annual Congress / September 27 - October 1 / Barcelona, Spain
  • 2019 Biennial Meeting / August 29-31 / Basel, Switzerland