The Discontinuation Rate with Collagenase Clostridium Histolyticum for Peyronie's Disease in a High-Volume Practice is Unexpectedly High: Identifying Opportunities for Patient Care Improvement.

To ellucidate reasons for premature discontinuation of Collagenase Clostridium Histoylyticum (CCH) injections for the treatment of penile curvature associated with Peyronie's Disease.

A database of men who underwent CCH injections at a single institution was queried to identify men who completed fewer than 8 injections. Chart review was conducted to identify reasons for treatment discontinuation. When this could not be identified, patients were contacted first via the online patient portal and next by phone.

Of 406 patients who underwent CCH treatment, 133 did not complete 8 injections (32.8%). The most common reasons for discontinuation were satisfactory curve reduction (27%), unsatisfactory curve reduction (21%), bothersome side effect (15%), and pursuit of surgery (12%). Other less common reasons included other health concerns, pausing treatment due to the Covid-19 pandemic, high cost, transferring care elsewhere, and lack of awareness that more injections were indicated.

We present the largest series of patients to date dedicated to evaluation of CCH discontinuation. We find that up to 1/3 of patients who begin CCH injections will not complete the full treatment course. Understanding the reasons for discontinuation can help providers better stratify patients for CCH treatment versus other modalities. In addition, as previous studies indicate curvature improvements are equally likely to be seen in the final four injections as the first four, our data points to the potential impact of improved patient education for individuals who discontinue due to unsatisfactory curve reduction.

Urology. 2023 Nov 08 [Epub ahead of print]

Kelly Lehner, Eileen Byrne, Mohamed Reza Roshandel, Manaf Alom, Sevann Helo, Tobias Kohler, Matthew Ziegelmann

Mayo Clinic Department of Urology, 200 First St SW, Rochester, MN 55902. Electronic address: ., Mayo Clinic Department of Urology, 200 First St SW, Rochester, MN 55902.