Peyronie's disease (PD) is a fibrosing disorder of the penis resulting in plaque formation and penile deformity, that negatively affect sexual and psychosocial function of patients. A multifactorial etiology of PD is assumed with diabetes mellitus (DM) being a potential risk factor.
The aim of this narrative review was to investigate diabetes role in PD pathophysiology, diagnosis, and treatment.
A non-systematic narrative review of original articles, meta-analyses, and randomized trials was conducted, including articles in the pre-clinical setting to support relevant findings.
Diabetes is one the most common comorbidity observed in PD patients, with a prevalence of about 11% and a strong association with erectile dysfunction (ED). DM is associated with both a higher risk of developing PD and has also an impact on the outcomes of PD's treatments.
Evidence from literature underlines that metabolic alterations typical of DM are pivotal factors in the development of PD and resistance to its medical treatment.
The role of DM in development of PD is still debated, while its role in PD development is not completely clear, there is a clear impact of DM on PD treatment outcomes. This article is protected by copyright. All rights reserved.
Andrology. 2022 Jun 30 [Epub ahead of print]
Simone Gianazza, Federico Belladelli, Riccardo Leni, Federica Masci, Piercarlo Rossi, Giuseppe Gianesini, Paolo Maggio, Emanuele Zaffuto, Andrea Salonia, Giulio Carcano, Federico Dehò, Paolo Capogrosso
University of Insubria, Varese, Italy., Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy., Department of Urology, Circolo & Fondazione Macchi Hospital - ASST Sette Laghi, Varese, Italy.