Objective - The search of effective approaches to Peyronie's disease treatment remains an urgent problem. In this study we had evaluated the efficiency of platelet-rich plasma therapy, low-intensity shock wave therapy, local negative-pressure therapy. On a basis of Men's Health Clinic (Kyiv, Ukraine), 23 patients with PD (ICD-10: N48.6) aged from 29 to 47 (mean age of 37.1±4.8) were examined using a questionnaire International Index of Erectile Function, Visual Analogue Scale for pain, cavernous bodies ultrasonography and pharmacodopplerography. The assessment of the reliability of the differences in the mean and relative variables carried out by means of standard methods of variation statistics (assessment of the reliability of the differences in the mean and relative variables was carried out by means of standard methods of variation statistics - Student's t-test, chi-squared test). We identified that 44% of patients had more than 2 induration focuses. In general study cohort, we had found 55 focuses of different square size. After 6-month follow-up observation following combined treatment we had identified significant (p≤0.01) decrease in pain intensity during erection - from moderate to low. There was a significant (p≤0.05) improvement of erectile function, increase of satisfaction with sexual intercourse and overall sexual satisfaction. Significant (p≤0.05) decrease in the end-diastolic blood flow velocity was observed. According to the data of ultrasonic examination, morphological effects of combined therapy were presented as a noticeable regress of fibroplastic process, reduction in the fibroplastic induction focuses by square size and density, penile deviations of less than 30о decreased by 6-12о. Follow-up data had shown a sustained therapy effect for all patients in study cohort. The efficiency of platelet-rich plasma therapy, low-intensity shock wave therapy, local negative-pressure combination has been established as promising.
Georgian medical news. 2019 Oct [Epub]
Clinic "Men's Health", Kyiv, Ukraine.