Peyronie's disease (PD) is associated with significant psychosocial distress, including anxiety, depression, and negative effects on interpersonal relationships. We report outcomes in a patient who researched an enzymatic supplement intended for oral administration for treatment of PD and subsequently self-injected it intravascularly. The enzyme, a combination of serrapeptase and nattokinase, resulted in vascular necrosis of the upper extremity. Despite attempts to salvage the limb, he ultimately required transhumeral amputation. Although extreme, this case illustrates the potential risks of non-Food and Drug Administration-approved therapies, the significant psychosocial impact that PD can have on patients' emotional well-being, and the extent to which some may go to seek treatment. Yang D, Savage J, Kohler T, et al. Vascular Necrosis of the Upper Extremity After Self-Treatment for Peyronie's Disease. Sex Med 2020;9:100282.
Sexual medicine. 2020 Dec 08 [Epub ahead of print]
David Yang, Joshua Savage, Tobias Köhler, Sevann Helo, Landon Trost, Matthew Ziegelmann
Department of Urology, Mayo Clinic, Rochester, MN, USA., Male Fertility and Peyronie's Clinic, Orem, UT, USA., Department of Urology, Mayo Clinic, Rochester, MN, USA. Electronic address: .