Clinical Trials

503 results for Prostate Cancer


Primary Radical Prostatectomy Versus Primary Radiotherapy for Locally Advanced Prostate Cancer: an Open Randomized Clinical Trial

  • Condition: Prostatic Neoplasms
  • Intervention: Procedure: Prostatectomy/Surgery, Other: Radiotherapy with adjuvant androgen deprivation therapy
  • Study ID: NCT02102477
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Focal Low Dose Rate ( LDR) Brachytherapy: Hemi-ablative Treatment With LDR for Patients With Low and Low-tier Intermediate Risk Prostate Cancer

  • Condition: Prostate Cancer
  • Intervention: Radiation: Transperineal template guided mapping biopsy, multiparametric MRI, Hemiablative Focal Brachytherapy
  • Study ID: NCT02643511
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Focal MR-Guided Focused Ultrasound Treatment of Localized Low and Intermediate Risk Prostate Cancer: Feasibility Study

  • Condition: Localized Low and Intermediae Risk Prostate Cancer
  • Intervention: Device: ExAblate MR Guided Focused Ultrasound, Device: ExAblate MR Guided Focused Ultrasound
  • Study ID: NCT01657942
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Focal MR-Guided Focused Ultrasound Treatment of Localized Low-Intermediate Risk Prostate Cancer: Feasibility Study

  • Condition: Localized Low-Intermediate Risk Prostate Cancer
  • Intervention: Device: MRgFUS Treatment
  • Study ID: NCT01226576
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A Multicenter, Prospective, Longitudinal Registry of Patients With Prostate Cancer in Asia

  • Condition: Prostatic Neoplasms
  • Intervention: Other: No Intervention
  • Study ID: NCT02546908
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Unilateral Nerve-Sparing Cryoablation for Low-Risk, Clinically Localized, Unilateral Prostate Cancer in Potent Men: A Prospective, Phase II Trial

  • Condition: Prostate Cancer
  • Intervention: Procedure: Unilateral Nerve-Sparing Cryoablation of the Prostate, Device: Precise Cryoablation System with IceRod Needles
  • Study ID: NCT02459912
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Randomised Phase 3 Trial of Enzalutamide in Androgen Deprivation Therapy With Radiation Therapy for High Risk, Clinically Localised, Prostate Cancer: ENZARAD

  • Condition: Prostatic Neoplasms
  • Intervention: Drug: Enzalutamide, Drug: Conventional NSAA, Drug: LHRHA, Radiation: External Beam Radiotherapy (78 Gy in 39 fractions or 46 Gy in 23 fractions plus brachytherapy boost)
  • Study ID: NCT02446444
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Virtual HDR CyberKnife Radiosurgery for Localized Prostatic Carcinoma: A Phase II Study

  • Condition: Prostate Cancer
  • Intervention: Radiation: CyberKnife Radiosurgery, Radiation: CyberKnife Radiosurgery
  • Study ID: NCT01045148
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Hypofractionated Radiosurgery for Localised Prostate Cancer

  • Condition: Prostate Cancer
  • Intervention: Radiation: Hypofractionated Radiosurgery
  • Study ID: NCT02635256
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Prospective Evaluation of Hypofractionation Proton Beam Therapy With Concurrent Treatment of the Prostate and Pelvic Nodes for Clinically Localized, High Risk or Unfavorable Intermediate Risk Prostate Cancer

  • Condition: Prostate Cancer
  • Intervention: Radiation: Hypofractionation Proton beam therapy with Concurrent Treatment of the Prostate and Pelvic Nodes
  • Study ID: NCT02874014
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Study of Stereotactic Body Radiotherapy (SBRT) for High-Risk Localized Prostrate Cancer

  • Condition: Adenocarcinoma of the Prostate, Stage III Prostate Cancer
  • Intervention: Radiation: stereotactic body radiation therapy, Other: quality-of-life assessment, Other: laboratory biomarker analysis, Drug: androgen deprivation therapy
  • Study ID: NCT02296229
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Phase II Single-arm Study Evaluating Neo-adjuvant (Pre-radical Radiotherapy) Abiraterone Acetate (Plus Prednisolone) and Gonadotropin-Releasing Hormone (GnRH) Agonist in High Risk Localised Prostate Carcinoma

  • Condition: High Risk Localised Prostate Carcinoma
  • Intervention: Drug: Abiraterone acetate, Prednisolone
  • Study ID: NCT02160353
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Localised Cancer of Prostate and Androgen Deficiency.

  • Condition: Cancer of Prostate
  • Intervention: Other: Blood sample
  • Study ID: NCT02235142
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A Randomized Phase I Study to Determine the Safety and Immunogenicity of ChAd-MVA Vaccination Compared to MVA Alone With and Without Low Dose Cyclophosphamide in Low and Intermediate Risk Localised Prostate Cancer

  • Condition: Prostate Cancer
  • Intervention: Biological: ChAdOx1.5T4, Biological: MVA.5T4, Drug: Cyclophosphamide
  • Study ID: NCT02390063
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A Phase 1 Trial for Evaluation of the Safety, Pharmacokinetics, and [18F] Radiation Dosimetry of CTT1057, a Small Molecule Inhibitor of Prostate Specific Membrane Antigen (PSMA)

  • Condition: Prostate Cancer
  • Intervention: Drug: CTT1057, Procedure: Prostatectomy
  • Study ID: NCT02916537
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Phase II Study of Hypofractionated Stereotactic Body Radiation Therapy as a Boost to the Prostate for Treatment of Localized, Non-Metastatic, High Risk Prostate Cancer

  • Condition: Prostate Cancer
  • Intervention: Radiation: CyberKnife Boost
  • Study ID: NCT01508390
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A Phase II Study of 68Ga-RM2 for PET/CT of Gastrin Releasing Peptide Receptor (GRPr) Expression in Prostate Cancer

  • Condition: Prostate Cancer
  • Intervention: Radiation: 68Ga-RM2 (RM2), Device: PET/CT Scan
  • Study ID: NCT02559115
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A Prospective Stage 2S Clinical Trial Evaluating Hemi-Ablative Low Dose Rate (LDR) Brachytherapy for Localised Prostate Cancer

  • Condition: Prostatic Neoplasms, Cancer of the Prostate
  • Intervention: Radiation: Hemi gland focal LDR brachytherapy
  • Study ID: NCT02632669
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Multiparametric MRI for Prostate Cancer Localization and Characterization Using Hyperpolarized Pyruvate (13C) Injection

  • Condition: Prostatic Neoplasms
  • Intervention: Drug: Hyperpolarized Pyruvate (13C) Injection
  • Study ID: NCT02647983
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Safety and Early Efficacy of Radical Prostatectomy for Newly Diagnosed Very High Risk Locally Advanced and Oligometastatic Prostate Cancer - a Prospective Single Center Phase I/II Study

  • Condition: Locally Advanced and Metastatic Prostate Cancer
  • Intervention: Procedure: Radical prostatectomy
  • Study ID: NCT02971358
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Impact of F-18-Fluorocholine PET/CT and MR Imaging/ Spectroscopy in the Management of Primary and Recurrent Prostate Cancer

  • Condition: Prostate Cancer
  • Study ID: NCT00963755
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Molecular-Genetic Correlates of Fatigue in Cancer Patients Receiving Localized External Beam Radiation Therapy

  • Condition: Cancer, Fatigue
  • Study ID: NCT00852111
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Phase III Study of Image Guided Radiation Therapy With or Without Androgen Suppression for Intermediate Risk Adenocarcinoma of the Prostate

  • Condition: Prostate Cancer
  • Intervention: Radiation: Radiation, Drug: Androgen Suppression Therapy
  • Study ID: NCT01492972
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Intervention Trial Evaluating Focal Therapy Using High Intensity Focused Ultrasound for the Treatment of Prostate Cancer

  • Condition: Prostate Cancer
  • Intervention: Procedure: Focal Therapy Using High Intensity Focused Ultrasound
  • Study ID: NCT02265159
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Serial mpMRI (Multi Parametric Magnetic Resonance Imaging) Scanning in Prostate Cancer After Androgen Deprivation Therapy and RadioTherapy (SMART)

  • Condition: Prostate Cancer
  • Intervention: Device: mpMRI/VERDICT, Radiation: External Beam Radiotherapy
  • Study ID: NCT02721784
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A Phase 1 Window of Opportunity Study Investigating the Pharmacodynamic Biomarker Effects of AZD2014 (an mTOR1/2 Inhibitor) Given Prior to Radical Prostatectomy

  • Condition: Prostate Cancer
  • Intervention: Drug: AZD2014
  • Study ID: NCT02064608
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Pharmacogenetic Study in Castration-resistant Prostate Cancer Patients Treated With Abiraterone Acetate

  • Condition: Pharmacogenetic Study
  • Intervention: Drug: Abiraterone Acetate
  • Study ID: NCT01858441
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VIRTUAL HDR CYBERKNIFE RADIOSURGERY FOR LOCALLY RECURRENT PROSTATIC CARCINOMA: A PHASE II STUDY

  • Condition: Recurrent Prostate Cancer
  • Intervention: Radiation: CyberKnife Radiosurgery
  • Study ID: NCT00851916
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Ultra-hypofractionated, Image-guided, Intensity-modulated Radiation Therapy in Combination With Brachytherapy for Clinically Localized, Intermediate Risk Prostate Cancer

  • Condition: Prostate Cancer
  • Intervention: Radiation: external beam radiation therapy, Radiation: brachytherapy, Behavioral: questionnaires
  • Study ID: NCT02280356
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A Randomised Feasibility Trial to Investigate the Timing of HDR Brachytherapy With EBRT in Intermediate and High Risk Localised Prostate CAncer Patients and Its Effects on Toxicity and Quality of Life

  • Condition: Prostate Cancer
  • Intervention: Radiation: Timing of HDR Brachytherapy to EBRT
  • Study ID: NCT02618161
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ATLAS: A Randomized, Double-blind, Placebo-controlled Phase 3 Study of JNJ-56021927 in Subjects With High-risk, Localized or Locally Advanced Prostate Cancer Receiving Treatment With Primary Radiation Therapy

  • Condition: Prostatic Neoplasms
  • Intervention: Drug: JNJ-56021927, Drug: Bicalutamide, Drug: Bicalutamide Placebo, Drug: JNJ-56021927 Placebo, Drug: GnRH (agonist), Radiation: 74-80 Grays (units of radiation)
  • Study ID: NCT02531516
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Hypofractionated Adaptive Image-Guided Radiation Therapy for Localized Adenocarcinoma of the Prostate

  • Condition: Prostate Cancer
  • Intervention: Radiation: hypofractionation
  • Study ID: NCT00809991
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Stereotactic Body Radiation Therapy and Short-Term Androgen Ablation for Intermediate-Risk, Localized, Adenocarcinoma of the Prostate

  • Condition: Adenocarcinoma of the Prostate
  • Intervention: Radiation: Radiation Therapy, Drug: Androgen Deprivation Therapy (ADT)
  • Study ID: NCT01517451
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Pilot Study of Eovist (Gadoxetate) Enhanced MRI for the Detection of Prostate Cancer

  • Condition: Prostate Cancer
  • Intervention: Drug: Eovist
  • Study ID: NCT01867424
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Phase I Clinical Trial of Stereotactic Ablative Radiotherapy (SABR) of Pelvis and Prostate Targets for Patients With High Risk Prostate Cancer

  • Condition: Prostate Cancer
  • Intervention: Radiation: Stereotactic Ablative Radiotherapy
  • Study ID: NCT02353819
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Phase 2 Study of 11C- and 18F-Choline PET/MR Imaging in Patients With Unfavorable Intermediate to High-Risk Prostate Cancer

  • Condition: Prostate Cancer
  • Intervention: Drug: Choline PET/MR
  • Study ID: NCT02397408
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The Impact of Androgen Ablation Therapy on Cognitive Functioning and Functional Status in Men With Prostate Cancer Age 65 and Older

  • Condition: Prostate Cancer
  • Intervention: Behavioral: Questionaires, Behavioral: Questionaires, Device: fMRI scan (optional)
  • Study ID: NCT00579072
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Detection and Localization of Carcinoma Using High Resolution Transrectal Imaging - Proof of Concept Study

  • Condition: Prostate Cancer
  • Intervention: Device: ProxiScan, Device: Magnetic Resonance Imaging, Device: SPECT-CT
  • Study ID: NCT02786459
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A Randomized, Double-Blind, Placebo-Controlled Trial of Metformin in Reducing Progression Among Men on Expectant Management for Low Risk Prostate Cancer: The MAST (Metformin Active Surveillance Trial) Study

  • Condition: Prostate Cancer
  • Intervention: Drug: Metformin, Drug: Placebo
  • Study ID: NCT01864096
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Electromagnetic Tracking of Devices During Interventional Procedures

  • Condition: Adenocarcinoma, Prostate Neoplasms
  • Study ID: NCT00102544
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MRI (Magnetic Resonance Imaging) Temperature Mapping of the Prostate and Urogenital Pelvis Cooled by an Endorectal Balloon

  • Condition: Prostate Cancer, Hypothermia, Urinary Incontinence, Erectile Dysfunction
  • Study ID: NCT01979848
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STUDY OF PREFERENCES IN MEN FACED WITH THE DIFFERENT TREATMENT OPTIONS FOR LOCALIZED PROSTRATE CANCER WITH A GOOD OR INTERMEDIATE PROGNOSIS

  • Condition: Patients Seen at a Urology Consultation
  • Intervention: Other: Questionnaire
  • Study ID: NCT02080793
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Investigation of Circulating Tumor Cells From Cancer Patients Undergoing Radiation Therapy

  • Condition: Circulating Tumor Cells
  • Intervention: Other: Blood draw
  • Study ID: NCT02449837
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18F-Fluciclovine PET/MRI for Detection of Recurrent Prostate Cancer After Radical Treatment

  • Condition: Prostate Cancer Recurrent
  • Study ID: NCT02562131
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Phase I Trial of In Situ Gene Therapy for Locally Recurrent Prostate Cancer Following Radiation Therapy Failure Using Sodium/Iodide Symporter and Radioiodine

  • Condition: Prostate Cancer
  • Intervention: Biological: Ad5-CMV-NIS, Drug: liothyronine sodium, Genetic: reverse transcriptase-polymerase chain reaction, Other: laboratory biomarker analysis, Radiation: iodine I 131
  • Study ID: NCT00788307
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Prostvac in Patients With Biochemically Recurrent Prostate Cancer

  • Condition: Prostate Cancer
  • Intervention: Biological: PROSTVAC -V, Biological: PROSTVAC-F, Other: Surveillance
  • Study ID: NCT02649439
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Phase 1 Trial of Oncolytic Adenovirus-Mediated Cytotoxic and Interleukin 12 Gene Therapy for Locally Recurrent Prostate Cancer After Definitive Radiotherapy

  • Condition: Prostate Cancer
  • Intervention: Biological: Ad5-yCD/mutTKSR39rep-hIL12
  • Study ID: NCT02555397
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68Ga-PSMA PET/CT for Detection of Recurrent Prostate Cancer After Initial Therapy

  • Condition: Prostate Adenocarcinoma, Recurrent Prostate Carcinoma
  • Intervention: Device: Computed Tomography, Radiation: Gallium Ga 68-labeled PSMA Ligand Glu-urea-Lys(Ahx)-HBED-CC, Other: Laboratory Biomarker Analysis, Device: Positron Emission Tomography
  • Study ID: NCT02940262
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Phase I-II Study HSV-tk + Valacyclovir Therapy in Combination With Brachytherapy for Recurrent Prostate Cancer With or Without Metastatic Disease

  • Condition: Prostatic Neoplasms
  • Intervention: Drug: HSV-tk +Valacyclovir in Combination with Brachytherapy
  • Study ID: NCT01913106
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A Phase 1A/1B, Two-Stage Study of a PSA/IL-2/GM-CSF Vaccine for the Treatment of PSA Recurrent Prostate Cancer in Hormone-Naive and Hormone-Independent Patients

  • Condition: Prostate Cancer
  • Intervention: Biological: PSA/IL-2/GM-CSF
  • Study ID: NCT02058680
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