Clinical Trials

505 results for Prostate Cancer


A Phase III Randomized Study of Hypofractionated Image-guided Volumetric Modulated Arc Radiotherapy (IG-VMAT) Versus Conventionally Fractionated IG-VMAT in Patients With Localized Prostate Cancer

  • Condition: Prostate Cancer
  • Intervention: Radiation: hypofraction, Radiation: convention
  • Study ID: NCT02934685
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RAD 1203: Pilot Trial Evaluating Stereotactic Body Radiotherapy With Integrated Boost for Clinically Localized Prostate Cancer

  • Condition: Prostate Cancer, Prostate Adenocarcinoma, Radiation Toxicity, Sexual Dysfunction
  • Intervention: Radiation: Stereotactic Body Radiation Therapy with Integrated Boost
  • Study ID: NCT01856855
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Phase 2 Study of Enzalutamide and GnRH Agonist Before, During and After Radiation Therapy in Treatment of Patients With High-risk Localized Prostate Cancer

  • Condition: Prostate Cancer
  • Intervention: Drug: Enzalutamide, Drug: Leuprolide acetate, Radiation: radiation
  • Study ID: NCT02064582
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Magnetic Resonance Guided Focal Stereotactic Body Radiation Therapy for Localized Prostate Cancer

  • Condition: Adenocarcinoma of the Prostate, Recurrent Prostate Cancer, Stage I Prostate Cancer, Stage IIA Prostate Cancer, Stage IIB Prostate Cancer
  • Intervention: Radiation: stereotactic radiosurgery, Procedure: magnetic resonance imaging, Other: quality-of-life assessment, Procedure: Serum Prostate Antigen Test, Procedure: Digital Rectal Exam, Behavioral: Expanded Prostate Cancer Index Composite
  • Study ID: NCT02163317
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A Randomized Controlled Trial of ProstAtak® as Adjuvant to Up-front Radiation Therapy For Localized Prostate Cancer

  • Condition: Prostate Cancer
  • Intervention: Biological: ProstAtak®(AdV-tk) + valacyclovir, Biological: Placebo + valacyclovir
  • Study ID: NCT01436968
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Randomized Placebo-Controlled, Double-Blind Study of Cholecalciferol Replacement in Patients on Expectant Management for Localized Prostate Cancer

  • Condition: Prostate Adenocarcinoma
  • Intervention: Dietary Supplement: Cholecalciferol, Other: Laboratory Biomarker Analysis, Other: Patient Observation, Drug: Placebo Administration, Other: Quality-of-Life Assessment, Other: Questionnaire Administration
  • Study ID: NCT00887432
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A Randomized Phase III, Factorial Design, of Cabazitaxel and Pelvic Radiotherapy in Patients With Localized Prostate Cancer and High-risk Features of Relapse

  • Condition: Adenocarcinoma of Prostate, Progression of Prostate Cancer
  • Intervention: Drug: Cabazitaxel, Radiation: Pelvic radiotherapy, Radiation: prostate radiotherapy
  • Study ID: NCT01952223
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A Phase IIA Exploratory, Randomized, Placebo-Controlled Trial of Pomegranate Fruit Extract/POMx™ in Subjects With Clinically Localized Prostate Cancer Undergoing Active Surveillance

  • Condition: Stage I Prostate Cancer, Stage IIA Prostate Cancer, Stage IIB Prostate Cancer
  • Intervention: Other: Laboratory Biomarker Analysis, Other: Pharmacological Study, Other: Placebo, Drug: Pomegranate-Extract Pill
  • Study ID: NCT02095145
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Hypofractionated Intensity Modulated and Image Guided Radiotherapy for Localized Prostate Cancer: a Prospective Cohort.

  • Condition: Prostatic Neoplasms
  • Intervention: Radiation: HypoIGRT
  • Study ID: NCT02651896
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Pre-Operative Gleason Score and PSA and Clinical Stage in Predicting the Risk of Failure in Patients Undergoing Radiation Therapy for Localized Prostate Cancer

  • Condition: Prostate Cancer, Radiation Toxicity
  • Intervention: Other: medical chart review, Other: questionnaire administration, Procedure: quality-of-life assessment, Radiation: brachytherapy, Radiation: radiation therapy
  • Study ID: NCT00769223
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A Pharmacodynamic Pre-surgical Study of Hedgehog Pathway Inhibition With LDE225 in Men With High-risk Localized Prostate Cancer.

  • Condition: Prostate Cancer
  • Intervention: Drug: LDE225
  • Study ID: NCT02111187
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Prospective Evaluation of CyberKnife® as Monotherapy or Boost Stereotactic Body Radiotherapy for Intermediate or High Risk Localized Prostate Cancer

  • Condition: Prostate Adenocarcinoma
  • Intervention: Radiation: CyberKnife, Other: Androgen Deprivation Therapy (ADT), Radiation: Intensity Modulated radiation therapy (IMRT)
  • Study ID: NCT01985828
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A Phase 1 Study of Allogeneic Human Bone Marrow Derived Mesenchymal Stem Cells in Localized Prostate Cancer

  • Condition: Prostate Cancer
  • Intervention: Biological: Allogeneic Human Mesenchymal Stem Cells
  • Study ID: NCT01983709
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Intimacy-Enhancing Couples' Intervention for Localized Prostate Cancer

  • Condition: Prostate Cancer, Sexual Dysfunction and Infertility, Sexuality
  • Intervention: Other: communication intervention, Other: counseling intervention, Other: nutrition intervention, Other: questionnaire administration
  • Study ID: NCT01982058
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Hypo-fractionated Stereotactic Body Radiotherapy for Localized Prostate Cancer

  • Condition: Prostate Cancer
  • Study ID: NCT01059513
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A Randomized Study of Enzalutamide in Patients With Localized Prostate Cancer Undergoing Active Surveillance (ENACT)

  • Condition: Prostate Cancer
  • Intervention: Drug: Enzalutamide, Other: Active Surveillance
  • Study ID: NCT02799745
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Circulating Tumor Cell Analysis in Patients With Localized Prostate Cancer Undergoing Prostatectomy

  • Condition: Prostate Cancer
  • Study ID: NCT01961713
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Evaluation of the TULSA-PRO MRI-guided Transurethral Ultrasound Prostate Ablation Device in Patients With Localized Prostate Cancer

  • Condition: Prostate Cancer
  • Intervention: Device: MRI-guided Transurethral Ultrasound Ablation
  • Study ID: NCT02766543
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A Phase II Randomized Trial Evaluating Acute and Late Toxicity of High-Dose Rate Brachytherapy and Low-Dose Rate Brachytherapy as Monotherapy in Localized Prostate Cancer

  • Condition: Prostate Cancer
  • Intervention: Radiation: Permanent Iodine-125 seed implant, Radiation: High-Dose-rate Prostate Brachytherapy
  • Study ID: NCT02628041
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Prostate Cancer E-Health-Tutorial (PROCET): Multicenter, One-armed Intervention Study to Evaluate an Online Tutorial for Patients With Localized Prostate Cancer

  • Condition: Prostate Cancer
  • Intervention: Other: Online tutorial
  • Study ID: NCT02503748
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A Phase I-II Dose Escalation Study of Stereotactic Body Radiation Therapy in Patients With Localized Prostate Cancer

  • Condition: Prostate Adenocarcinoma
  • Intervention: Radiation: Stereotactic Body Radiation Therapy (SBRT)
  • Study ID: NCT02254746
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Phase II Randomized, Placebo-Controlled Trial of PROSTVAC (PSA-TRICOM) in Patients With Clinically Localized Prostate Cancer Undergoing Active Surveillance

  • Condition: Stage I Prostate Adenocarcinoma, Stage II Prostate Adenocarcinoma
  • Intervention: Other: Laboratory Biomarker Analysis, Other: Placebo, Biological: Rilimogene Galvacirepvec
  • Study ID: NCT02326805
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Tumor Targeted Radiotherapy for Patients With Localized Prostate Cancer

  • Condition: Prostate Cancer
  • Intervention: Radiation: Volumetric Modulated Arc Therapy (VMAT) and High-Dose Rate (HDR) Radiotherapy, Other: No Active Treatment - completed Prior Radiation
  • Study ID: NCT01802242
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A Pilot Study of Magnetic Resonance (MR) Imaging With Hyperpolarized Pyruvate (13C) to Detect High Grade Localized Prostate Cancer

  • Condition: Prostate Cancer
  • Intervention: Drug: Pyruvate (13C)
  • Study ID: NCT02526368
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Effect of Different Exercise Regimens on Intratumoral Natural Killer (NK) Cell Variability in Men With Localized Prostate Cancer Undergoing Radical Prostatectomy - a Randomized Controlled Pilot Study

  • Condition: Prostate Cancer
  • Intervention: Behavioral: High Intensity Interval Training, Behavioral: Moderate-Intensity Aerobic and Resistance Training, Behavioral: Usual Care Observational Control
  • Study ID: NCT02954783
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The UCLA ASCAP Project is an Observational, Longitudinal, and Open-ended Study Aimed at Establishing a Structured Program of Non-interventional Follow-up for Localized Prostate Cancer.

  • Condition: Prostate Cancer
  • Intervention: Other: Active surveillance
  • Study ID: NCT00949819
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A Prospective Single-Arm Phase I/II Study Using 11C-Choline PET Scans for Dose Escalated Hypofractionated Image Guided Inversely Planned Intensity Modulated External Beam Radiotherapy With Boost to PET Defined Dominant Intraprostatic Lesions and as a Pred

  • Condition: Prostatic Neoplasms
  • Intervention: Radiation: 11C-Choline
  • Study ID: NCT02004418
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Phase II Study of Feasibility of Focal Therapy for Prostate Cancer of Good Prognosis With Permanent I125 Localized Implant.

  • Condition: Localized Prostate Cancer
  • Intervention: Radiation: Focal brachytherapy
  • Study ID: NCT01902680
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Phase II Trial of Hypofractionated Proton Beam Therapy in Men With Localized Prostate Adenocarcinoma

  • Condition: Prostate Cancer
  • Intervention: Radiation: Proton Beam Therapy, Behavioral: Questionnaire
  • Study ID: NCT01950351
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Comparison of High-dose- Versus Low-dose-rate Brachytherapy as Monotherapy in the Treatment of Early, Organ Confined Prostate Cancer.

  • Condition: Adenocarcinoma of Prostate
  • Intervention: Radiation: LDR Brachytherapy, Radiation: HDR Brachytherapy
  • Study ID: NCT02258087
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Prospective Evaluation of CyberKnife Stereotactic Body Radiotherapy for Localized Prostate Cancer: Risk Stratified Monotherapy Versus Boost

  • Condition: Prostate Cancer
  • Intervention: Radiation: Stereotactic Ablative Body Radiotherapy as Monotherapy, Radiation: Stereotactic Ablative Body Radiotherapy as a Boost
  • Study ID: NCT02016248
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An Open Label, Randomized Phase 2 Trial of Prostvac and Ipilimumab as Monotherapy or in Combination for Men With Localized Prostate Cancer Undergoing Radical Prostatectomy

  • Condition: Prostatic Neoplasms
  • Intervention: Biological: PROSTVAC V/F, Drug: Ipilimumab
  • Study ID: NCT02506114
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Perioperative Pelvic Floor Muscle Training May Improve Recovery of Continence in Men With Localized Prostate Cancer Undergoing Robot-Assisted Radical Prostatectomy

  • Condition: Prostate Cancer, Urinary Incontinence, Pelvic Floor Physical Therapy
  • Intervention: Behavioral: Pelvic Floor Muscle Physical Therapy, Behavioral: Control Group
  • Study ID: NCT02558946
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Study of Non-Invasive Viberect® Penile Vibratory Stimulation Regimen to Enhance Recovery of Erectile Function/Rigidity and Urinary Control/Continence After Nerve Sparing Radical Prostatectomy (RP) for Clinically Localized Prostate Cancer.

  • Condition: Erectile Dysfunction Following Radical Prostatectomy, Urinary Incontinence of Non-organic Origin
  • Intervention: Device: Viberect device
  • Study ID: NCT01718704
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Whole-Pelvic Radiotherapy With a Stereotactic Body Radiotherapy Boost and Long-Term Androgen Deprivation for Unfavorable-Intermediate and High Risk Localized Adenocarcinoma of the Prostate.

  • Condition: Adenocarcinoma of the Prostate
  • Intervention: Radiation: Stereotactic Radiosurgical Boost3, Drug: Casodex, Drug: Leuprolide
  • Study ID: NCT02064036
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Focal Prostate Radio-Frequency Ablation for the Treatment of Prostate Cancer

  • Condition: Prostate Cancer
  • Intervention: Procedure: Radio-Frequency Ablation (RFA)
  • Study ID: NCT02328807
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An Open Registry to Measure the Impact of Adding Genomic Testing (Prolaris®) on the Treatment Decision Following Biopsy in Newly Diagnosed Prostate Cancer Patients at Intermountain Hospitals

  • Condition: Prostate Cancer
  • Intervention: Behavioral: Registry
  • Study ID: NCT02454595
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Retrospective Analysis of Quality of Life After Permanent Interstitial Iodine Seed Brachytherapy for Prostate Cancer

  • Condition: Neoplasms, Prostate
  • Intervention: Other: No intervention in this retrospective study
  • Study ID: NCT02652000
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Early Changes in Multiparametric MRI in Response to Neoadjuvant Androgen Deprivation and External Beam Radiation Therapy for Prostate Cancer

  • Condition: Prostate Cancer
  • Intervention: Device: MRI, Other: PSA Blood Test
  • Study ID: NCT01959542
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Patient Over 75 Years With Prostate Cancer: Geriatric Determinants of General Repercussion of Radiotherapy With Curative Intent

  • Condition: Prostate Cancer
  • Intervention: Other: geriatric assessment and quality of life, Radiation: Radiotherapy
  • Study ID: NCT02876237
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Prospective Phase III Randomized Trial of Prostate Only or Whole Pelvic RadioTherapy in High Risk Prostate Cancer (POP-RT) Trial

  • Condition: Prostate Cancer
  • Intervention: Radiation: IGRT
  • Study ID: NCT02302105
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A Pilot Study to Evaluate the Reproducibility of Magnetic Resonance (MR) Imaging With Hyperpolarized Pyruvate (13C) and Its Ability to Reflect Treatment Effects in Patients With Prostate Cancer

  • Condition: Prostate Cancer
  • Intervention: Drug: Pyruvate
  • Study ID: NCT02450201
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A Randomized Clinical Trial Comparing the Efficacy of MRI Versus PSA for Prostate Cancer Screening: The MVP Study (MRI vs PSA)

  • Condition: Prostate Cancer
  • Intervention: Device: Multi-parametric MRI, Other: PSA testing
  • Study ID: NCT02799303
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Erythropoietin to Enhance Erection Recovery in Men Following Radical Prostatectomy

  • Condition: Prostate Cancer, Erectile Dysfunction
  • Intervention: Drug: Placebo, Drug: EPO
  • Study ID: NCT00737893
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A Phase II, Prospective Study of MRI in the Reclassification of Men Considering Active Surveillance in Prostate Cancer

  • Condition: Prostate Cancer
  • Intervention: Device: Multiparametric MRI, Procedure: Prostate biopsy
  • Study ID: NCT01858688
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Phase II Trial Assessing the Feasibility and Toxicity of Degarelix in Achieving Prostate Downsizing Prior to Treatment With Permanent Seed Prostate Brachytherapy

  • Condition: Prostate Cancer
  • Intervention: Drug: Degarelix, Drug: Degarelix
  • Study ID: NCT01446991
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Hypoxia and Stem Cell Content as Aggression Factors in Prostate Cancer

  • Condition: Prostate Cancer
  • Intervention: Drug: Pimonidazole
  • Study ID: NCT02095249
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Pilot Study of Whole Gland Salvage HDR Prostate Brachytherapy for Locally Recurrent Prostate Cancer

  • Condition: Prostate Cancer Recurrent
  • Intervention: Radiation: HDR brachytherapy
  • Study ID: NCT02560181
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A Pilot Study of 18F-DCFBC PET/CT in Prostate Cancer

  • Condition: Prostatic Neoplasms, Prostate Cancer
  • Intervention: Drug: 18F DCFBC
  • Study ID: NCT02190279
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A Randomized Controlled Trial Of AdV-tk + Valacyclovir Administered During Active Surveillance For Newly Diagnosed Prostate Cancer

  • Condition: Prostate Cancer
  • Intervention: Biological: aglatimagene besadenovec, Biological: placebo, Drug: valacyclovir
  • Study ID: NCT02768363
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