A Phase 3 Randomized, Placebo-controlled, Double-blind Study of Apalutamide Plus Androgen Deprivation Therapy (ADT) Versus ADT in Subjects With Metastatic Hormone-sensitive Prostate Cancer (mHSPC)


Condition: Prostate Cancer

Intervention:

  • Drug: Apalutamide
  • Drug: Placebo
  • Drug: Androgen Deprivation Therapy (ADT)

Purpose: The purpose of this study is to determine if the addition of apalutamide to ADT provides superior efficacy in improving radiographic progression-free survival (rPFS) or overall survival (OS) for participants with mHSPC.

Study Type: Interventional

Clinical Trials Identifier NCT 8-digits: NCT02489318

Sponsor: Aragon Pharmaceuticals, Inc.

Primary Outcome Measures:

  • Measure: Radiographic Progression-Free Survival (rPFS)
  • Time Frame: Up to 54 Months
  • Safety Issue:
  • Measure: Overall Survival (OS)
  • Time Frame: Up to 54 Months
  • Safety Issue:

Secondary Outcome Measures:

  • Measure: Time to Pain Progression
  • Time Frame: Up to 54 Months
  • Safety Issue:
  • Measure: Time to Skeletal-Related Event (SRE)
  • Time Frame: Up to 54 Months
  • Safety Issue:
  • Measure: Time to Chronic Opioid Use
  • Time Frame: Up to 54 Months
  • Safety Issue:
  • Measure: Time to Initiation of Cytotoxic Chemotherapy
  • Time Frame: Up to 54 Months
  • Safety Issue:

Estimated Enrollment: 1000

Study Start Date: November 27, 2015

Phase: Phase 3

Eligibility:

  • Age: minimum 18 Years maximum N/A
  • Gender: Male

Inclusion Criteria:

  • Diagnosis of prostate adenocarcinoma as confirmed by the investigator
  • Metastatic disease documented by greater than or equal to (>=) 1 bone lesions on 99mTc bone scan. Participants with a single bone lesion must have confirmation of bone metastasis by computed tomography (CT) or magnetic resonance imaging (MRI)
  • Eastern Cooperative Oncology Group Performance Status (ECOG PS) grade of 0 or 1
  • Participants who received docetaxel treatment must meet the following criteria: a) Received a maximum of 6 cycles of docetaxel therapy for mHSPC; b) Received the last dose of docetaxel <=2 months prior to randomization; c) Maintained a response to docetaxel of stable disease or better, by investigator assessment of imaging and PSA, prior to randomization
  • Other allowed prior treatment for mHSPC: a) Maximum of 1 course of radiation or surgical intervention; radiation therapy for metastatic lesions must be completed prior to randomization; b) Less than or equal to (<=) 6 months of ADT prior to randomization
  • Allowed prior treatments for localized prostate cancer (all treatments must have been completed >= 1 year prior to randomization) a) <= 3 years total of ADT; b) All other forms of prior therapies including radiation therapy, prostatectomy,lymph node dissection, and systemic therapies

Exclusion Criteria:

  • Pathological finding consistent with small cell, ductal or neuroendocrine carcinoma of the prostate
  • Known brain metastases
  • Lymph nodes as only sites of metastases
  • Visceral (ie, liver or lung) metastases as only sites of metastases
  • Other prior malignancy less than or equal to 5 years prior to randomization with the exception of squamous or basal cell skin carcinoma or non-invasive superficial bladder cancer
  • Prior treatment with other next generation anti-androgens or other CYP17 inhibitors, immunotherapy or radiopharmaceutical agents for prostate cancer
  • History of seizures or medications known to lower seizure threshold

Contact:

  • Use link at the bottom of the page to see if you qualify for an enrolling site (see list). If you still have questions:

Locations:

  • Urology Centers Of Alabama
  • Homewood Alabama 35209 United States
  • 21st Century Oncology
  • Scottsdale Arizona 85251 United States
  • Arizona Institute of Urology
  • Tucson Arizona 85704 United States
  • Urological Associates of Southern Arizona, P.C.
  • Tucson Arizona 85741 United States
  • Cedars-Sinai Medical Center
  • Los Angeles California 90048 United States
  • Greater Los Angeles VA Healthcare System
  • Los Angeles California 90073 United States
  • San Bernardino Urological Associates
  • San Bernardino California 92404 United States
  • Genesis Research
  • San Diego California 92123 United States
  • The Urology Center of Colorado
  • Denver Colorado 80211 United States
  • Norwalk Hospital
  • Norwalk Connecticut 06477 United States
  • 21st Century Oncology
  • Fort Myers Florida 33908 United States
  • Jesse Brown VAMC Department of Surgery
  • Chicago Illinois 60612 United States
  • Rush University
  • Chicago Illinois 60612 United States
  • Fort Wayne Medical Oncology and Hematology, Inc.
  • Fort Wayne Indiana 46804 United States
  • First Urology
  • Jeffersonville Indiana 47130 United States
  • Tulane University School of Medicine - Tulane Cancer Center Comprehensive Clinic (TCCCC)
  • New Orleans Louisiana 70112-2618 United States
  • Ochsner Clinic Foundation
  • New Orleans Louisiana 70121 United States
  • University of Maryland
  • Baltimore Maryland 21201-1544 United States
  • MidAtlantic Urology Associates
  • Greenbelt Maryland 20770 United States
  • Maryland Oncology Hematology, PA
  • Rockville Maryland 20850 United States
  • Chesapeake Urology Research Associates
  • Towson Maryland 21204 United States
  • Sparrow Regional Cancer center
  • Lansing Michigan 48912 United States
  • Michigan Institute of Urology
  • Troy Michigan 48084 United States
  • Metro Urology
  • Woodbury Minnesota 55125 United States
  • Nebraska Cancer Specialists
  • Omaha Nebraska 68130 United States
  • Comprehensive Cancer Centers of Nevada
  • Las Vegas Nevada 89169 United States
  • Maimonides Cancer Center
  • Brooklyn New York 11220 United States
  • Premier Medical Group
  • Poughkeepsie New York 12601 United States
  • Associated Medical Professionals
  • Syracuse New York 13210 United States
  • Montefiore Medical Center
  • The Bronx New York 10461 United States
  • Associated Urologists of North Carolina
  • Raleigh North Carolina 27612 United States
  • W. G. 'Bill' Hefner VA Medical Center
  • Salisbury North Carolina 28144 United States
  • Piedmont Medical Research
  • Winston-Salem North Carolina 27103 United States
  • Wake Forest University Baptist Medical Center (WFUBMC) - Comprehensive Cancer Center
  • Winston-Salem North Carolina 27157 United States
  • TriState Urologic Services PSC Inc. DBA The Urology Group
  • Cincinnati Ohio 45212 United States
  • University Hospitals Case Medical Center
  • Cleveland Ohio 44106 United States
  • Clinical Research Solutions, LLC
  • Middleburg Heights Ohio 44130 United States
  • Oregon Urology Institute
  • Springfield Oregon 97477 United States
  • Urologic Consultants of SE PA
  • Bala-Cynwyd Pennsylvania 19004 United States
  • Urology Health Specialists, LLC
  • Bryn Mawr Pennsylvania 19010 United States
  • Lancaster Urology
  • Lancaster Pennsylvania 17604 United States
  • Ralph H. Johnson VAMC and Medical University of South Carolina
  • Charleston South Carolina 29401 United States
  • Carolina Urologic Research Center
  • Myrtle Beach South Carolina 29572 United States
  • Urology Associates
  • Nashville Tennessee 37209 United States
  • Urology Clinics of North Texas
  • Dallas Texas 75231 United States
  • Texas Oncology P.A.
  • Houston Texas 77024 United States
  • Houston Metro Urology
  • Houston Texas 77027 United States
  • Urology San Antonio Research
  • San Antonio Texas 78229 United States
  • University of Utah
  • Salt Lake City Utah 84112 United States
  • Virginia Urology Center
  • Richmond Virginia 23235 United States
  • Urology of Virginia, PLCC
  • Virginia Beach Virginia 23642 United States
  • Seattle Urology Research Center
  • Burien Washington 98166 United States
  • Medical Oncology Associates, PS
  • Spokane Washington 99208 United States
  • Madigan Army Medical Center
  • Tacoma Washington 98431 United States
  • University of Wisconsin Carbone Cancer Center
  • Madison Wisconsin 53792 United States
  • Medical College Of Wisconsin
  • Milwaukee Wisconsin 53226-3522 United States
  • COIBA
  • Berazategui B1880BBF Argentina
  • Fundación Investigar
  • C.a.b.a. C1025ABI Argentina
  • Sanatorio Guemes
  • C.a.b.a. C1180AAX Argentina
  • Hospital Italiano de Buenos Aires
  • C.a.b.a. C1181ACF Argentina
  • Instituto Medico Alexander Fleming
  • C.a.b.a. C1426ANZ Argentina
  • Hospital Militar Cosme Argerich
  • C.a.b.a. C1426BOR Argentina
  • Centro de Urologia (CDU)
  • Ciudad Automoma Buenos Aires C1120AAT Argentina
  • CEMIC Saavedra
  • Ciudad Autonoma Buenos Aires C1431FWN Argentina
  • Fundacion Favaloro
  • Ciudad Autonoma De Buenos Aires 1093 Argentina
  • Clínica Adventista Belgrano
  • Ciudad De Buenos Aires C1430EGF Argentina
  • Clinica Sucre
  • Cordoba 5000 Argentina
  • Instituto Oncologico de Cordoba (IONC)
  • Cordoba X5000HXL Argentina
  • Clinica Universitaria Reina Fabiola
  • Cordoba X5004FHP Argentina
  • H.I.G.A. San Roque de Gonnet
  • La Plata 1900 Argentina
  • Centro Oncológico Riojano Integral
  • La Rioja F5300COE Argentina
  • Centro de Investigacion Pergamino SA
  • Pergamino B2700CPM Argentina
  • Sanatorio Britanico de Rosario
  • Rosario 2000 Argentina
  • Instituto de Oncologia de Rosario (IOR)
  • Rosario S2000KZE Argentina
  • Centro Médico San Roque
  • San Miguel De Tucuman T4000IAK Argentina
  • ARS Médica
  • San Salvador De Jujuy Y4600AFW Argentina
  • Clínica Viedma
  • Viedma R8500ACE Argentina
  • Border Medical Oncology Research Unit
  • Albury 2640 Australia
  • The Lyell McEwin Hospital
  • Elizabeth Vale 5112 Australia
  • St George Private Hospital
  • Kogarah 2217 Australia
  • North Coast Cancer Institute
  • Port Macquarie 2444 Australia
  • Mater Hospital Brisbane
  • South Brisbane 4101 Australia
  • Northern Cancer Institute
  • St Leonards 2065 Australia
  • St John of God Subiaco Hospital
  • Subiaco 6008 Australia
  • Fundacao Pio Xii - Hospital De Cancer De Barretos
  • Barretos 14784-400 Brazil
  • UNICAMP
  • Campinas 13083-970 Brazil
  • Centro de Pesquisas Oncológicas - CEPON
  • Florianópolis 88034-000 Brazil
  • Hospital Araújo Jorge da Associação de Combate ao Câncer em Goiás
  • Goiânia 74605-070 Brazil
  • Hospital de Caridade de Ijui - CACON
  • Ijui 98700-000 Brazil
  • Liga Norte Riograndense Contra O Cancer
  • Natal 59075-740 Brazil
  • Irmandade Santa Casa de Misericordia de Porto Alegre
  • Porto Alegre 90020-090 Brazil
  • Hospital de Clínicas de Porto Alegre
  • Porto Alegre 90035-904 Brazil
  • IRPCC - Instituto Ribeiraopretano de Combate ao Cancer
  • Ribeirao Preto 14015-130 Brazil
  • Instituto Nacional do Cancer - INCA
  • Rio De Janeiro 20231-050 Brazil
  • Hospital Universitário Pedro Ernesto
  • Rio De Janeiro 20551-030 Brazil
  • Instituto COI de Pesquisa, Educação e Gestão
  • Rio De Janeiro 22793-080 Brazil
  • Hospital Santa Isabel
  • Salvador 40050-410 Brazil
  • Núcleo de Oncologia da Bahia
  • Salvador 42700-000 Brazil
  • CEPHO - Centro de Estudos e Pesquisa de Hematologia e Oncologia
  • Santo André 09060-650 Brazil
  • Fundacao Faculdade Regional De Medicina De Sao Jose Do Rio Preto
  • Sao Jose Do Rio Preto 15090-000 Brazil
  • Centro de Pesquisa do Instituto do Cancer Arnaldo Vieira de Carvalho
  • Sao Paulo 01209-000 Brazil
  • IBCC Instituto Brasileiro de Controle do Cancer
  • Sao Paulo 03102-002 Brazil
  • Hospital Santa Marcelina
  • Sao Paulo 08270-070 Brazil
  • Centro de Estudos e Pesquisas Oncologicas de Sorocaba (Instituto de Oncologia de Sorocaba)
  • Sorocaba 18030-075 Brazil
  • Sociedade Hospital Samaritano
  • São Paulo 01232-010 Brazil
  • ICESP - Instituto do Câncer do Estado de São Paulo
  • São Paulo 01246-000 Brazil
  • Hospital Sirio Libanes
  • São Paulo 01308-050 Brazil
  • Fundação Antônio Prudente - A.C. Camargo Cancer Center
  • São Paulo 01509-900 Brazil
  • Instituto de Assistência Médica ao Servidor Público Estadual - HSPE-FMO
  • São Paulo 04039-004 Brazil
  • Hospital Israelita Albert Einstein
  • São Paulo 05651-900 Brazil
  • Southern Alberta Institute of Urology / Prostate Cancer Centre
  • Calgary Alberta T2V 1P9 Canada
  • Vancouver Prostate Centre, Gordon and Leslie Diamond Health Care Centre
  • Vancouver British Columbia V5Z 1M9 Canada
  • McMaster Institute of Urology
  • Hamilton Ontario L8N 4A6 Canada
  • Centre for Applied Urological Research
  • Kingston Ontario K7L 3J7 Canada
  • Princess Margaret Cancer Centre
  • Toronto Ontario M5G 2M9 Canada
  • Centre hospitalier universitaire de Québec (CHUQ), L'Hotel-Dieu de Quebéc
  • Quebec G1R 2J6 Canada
  • Cancer Institute and Hospital, Chinese Academy of Medical Sciences(CAMS)
  • Beijing 100022 China
  • Peking Union Medical College Hospital
  • Beijing 100032 China
  • Peking University First Hospital
  • Beijing 100034 China
  • Beijing Friendship Hospital
  • Beijing 100050 China
  • Beijing Cancer Hospital of Peking University
  • Beijing 100142 China
  • Peking University Shougang Hospital
  • Beijing 100144 China
  • Peking University Third Hospital
  • Beijing 100191 China
  • Beijing Hospital
  • Beijing 100730 China
  • Hunan Cancer hospital
  • Changsha 410013 China
  • The people's Hospital of Sichuan Province
  • Chengdu 610072 China
  • Chongqing Cancer hospital
  • Chongqing 400030 China
  • Southwest Hospital
  • Chongqing 400038 China
  • Fujian Medical University Union Hospital
  • Fuzhou 350001 China
  • Sun Yat-Sen University Cancer Center
  • Guangzhou 430030 China
  • Sun Yat-Sen Memorial Hospital Sun Yat-sen University
  • Guangzhou 510120 China
  • Guangzhou First Municipal People's Hospital
  • Guangzhou 510180 China
  • The Second Affiliated Hospital of Zhejiang University
  • Hangzhou 310009 China
  • Anhui Province Hospital
  • Hefei China
  • The First Affiliated hospital of Anliui Medical University
  • Hefei China
  • Jiangsu Cancer Hospital
  • Nanjing 210000 China
  • Nanjing Drum Tower Hospital
  • Nanjing 210008 China
  • Jiangsu Province Hospital
  • Nanjing 210029 China
  • Fudan Cancer Hospital
  • Shanghai 200032 China
  • Shanghai Zhongshan Hospital
  • Shanghai 200032 China
  • ShangHai Huadong Hospital
  • Shanghai 200040 China
  • Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
  • Shanghai 200093 China
  • Renji Hospital, Shanghai Jiaotong University School of Medicine
  • Shanghai 200127 China
  • ShangHai Changhai Hospital
  • Shanghai 200433 China
  • Shanghai General Hospital
  • Shanghai 201620 China
  • Second Affiliated Hospital, SooChow University
  • Suzhou 215004 China
  • First Affiliated Hospital, SooChow University
  • Suzhou 215006 China
  • The Second Hospital of Tianjin Medical University
  • Tianjin 300211 China
  • Wuhan Tongji Hospital, Tongji Medical College
  • Wuhan 430030 China
  • Wuxi People's Hospital
  • Wuxi 214023 China
  • First Affiliated Hospital, Xi'an Jiaotong University
  • Xi'An 710004 China
  • Fakultni nemocnice Hradec Kralove
  • Hradec Králove 500 05 Czechia
  • Krajská nemocnice Liberec
  • Liberec 460 63 Czechia
  • Nemocnice Novy Jicin a.s., oddeleni radioterapie a onkologie
  • Nový Jicin 741 01 Czechia
  • Urologicka klinika FNOL
  • Olomouc 775 20 Czechia
  • Slezska nemocnice v Opave
  • Opava 746 01 Czechia
  • Onkologicke Centrum Multiscan
  • Pardubice 532 03 Czechia
  • Fakultni nemocnice Kralovske Vinohrady
  • Praha 10 100 34 Czechia
  • Urocentrum Praha
  • Praha 2 120 00 Czechia
  • Urologicka klinika 1.LF UK a VFN
  • Praha 2 120 00 Czechia
  • Thomayerova nemocnice
  • Praha 4 140 59 Czechia
  • Urologicka klinika 2.LF UK a FN Motol
  • Praha 5 150 00 Czechia
  • Nemocnice Na Bulovce
  • Praha 8 180 00 Czechia
  • Krajska Nemocnice T. Bati a.s. (KNTB) - Ambulance Urologicka
  • Zlin 762 75 Czechia
  • CHU Gabriel-Montpied
  • Clermont Ferrand 63000 France
  • Institut du Cancer de Montpellier
  • Montpellier 34298 France
  • Centre d'oncologie de Gentilly
  • Nancy 54100 France
  • Institut Mutualiste Montsouris
  • Paris 75014 France
  • Hopital Europeen Georges-Pompidou
  • Paris 75015 France
  • Centre hospitalier Lyon-Sud
  • Pierre Bénite 69495 France
  • Strasbourg Oncologie Libérale
  • Strasbourg 67000 France
  • Hopital Foch
  • Suresnes 92151 France
  • Urologisches Zentrum Bonn
  • Bonn 53111 Germany
  • Städtisches Klinikum Braunschweig gGmbH-Klinik für Urologie und Uroonkologie
  • Braunschweig 38126 Germany
  • Martini-Klinik am Universitätsklinikum Hamburg-Eppendorf Urologie
  • Hamburg 20246 Germany
  • Urologikum Hamburg
  • Hamburg 22399 Germany
  • Medizinische Hochschule Hannover
  • Hannover 30625 Germany
  • Praxis Dr. med. Silvio Szymula
  • Leipzig 04105 Germany
  • Universitätsklinikum Schleswig Holstein Campus Lübeck
  • Lubeck 23538 Germany
  • Praxis Dr. med. Ralf Eckert
  • Lutherstadt Eisleben 06295 Germany
  • Studienpraxis Urologie Nürtingen
  • Nürtingen 72622 Germany
  • Klinikverbund Südwest Medical Center Sindelfingen-Böblingen
  • Sindelfingen 71065 Germany
  • Klinikum St. Elisabeth Straubing GmbH
  • Straubing 94315 Germany
  • Semmelweis Egyetem, Urológia Klinika
  • Budapest 1082 Hungary
  • Egyesitett Szent Istvan Es Szent Laszlo Korhaz Rendelointezet
  • Budapest 1097 Hungary
  • Országos Onkológiai Intézet, C Belgyógyászati-Onkológiai és Klinikai Farmakológiai Osztály
  • Budapest 1122 Hungary
  • Petz Aladar Megyei Oktato Korhaz
  • Győr 9023 Hungary
  • Uro-Clin Kft.
  • Pécs 7621 Hungary
  • Soproni Gyógyközpont, Urológia Osztály
  • Sopron 9400 Hungary
  • Soroka Medical Center
  • Beer Sheva 85101 Israel
  • Rambam Medical Center
  • Haifa 31096 Israel
  • Wolfson Medical Center
  • Holon 58100 Israel
  • Meir Medical Center
  • Kfar Saba 44281 Israel
  • Rabin Medical Center
  • Petach Tikva 49100 Israel
  • Sheba Medical Center
  • Ramat Gan 52621 Israel
  • Asaf Harofe Medical Center
  • Zrifin 60930 Israel
  • Chiba Cancer Center
  • Chuo-Ku, Chiba-City 260-8717 Japan
  • Harasanshin Hospital
  • Hakata-Ku 812-0033 Japan
  • Dokkyo Medical University Koshigaya Hospital
  • Koshigaya-Shi 343-8555 Japan
  • NHO Shikoku Cancer Center
  • Matsuyama 791-0280 Japan
  • Kitasato University Hospital
  • Minami-Ku, Sagamihara-Shi 252-0375 Japan
  • University of Miyazaki Hospital
  • Miyazaki 889-1692 Japan
  • Nagano Municipal Hospital
  • Nagano 381-8551 Japan
  • Nagasaki University Hospital
  • Nagasaki 852-8501 Japan
  • Kindai University Hospital
  • Osaka-Sayama 589-8511 Japan
  • Osaka International Cancer Institute
  • Osaka-Shi 541-8567 Japan
  • Toho University Sakura Medical Center
  • Sakura 285-8741 Japan
  • Hokkaido University Hospital
  • Sapporo 060-8648 Japan
  • Yokohama City University Medical Center
  • Yokohama 232-0024 Japan
  • Oita University Hospital
  • Yufu 879-5593 Japan
  • Kyungpook National University Chilgok Hospital
  • Daegu 702-210 Korea, Republic of
  • Chungnam National University Hospital
  • Daejeon 301-721 Korea, Republic of
  • National Cancer Center
  • Goyangsi 410 769 Korea, Republic of
  • Chonnam National University Hwasun Hospital
  • Hwasun-Gun 519-809 Korea, Republic of
  • Seoul National University Bundang Hospital
  • Seongnam 13605 Korea, Republic of
  • Seoul National University Hospital
  • Seoul 03080 Korea, Republic of
  • Severance Hospital, Yonsei University Health System
  • Seoul 03722 Korea, Republic of
  • Gangnam Severance Hospital
  • Seoul 06273 Korea, Republic of
  • Seoul St. Mary's Hospital
  • Seoul 06591 Korea, Republic of
  • Samsung Medical Center
  • Seoul 135 710 Korea, Republic of
  • Korea University Hospital
  • Seoul 136 705 Korea, Republic of
  • Asan Medical Center
  • Seoul 138-736 Korea, Republic of
  • Instituto Metropolitano de Investigación Clínica S.C
  • Ciudad De México 14370 Mexico
  • Consultorio de Especialidad en Urologia Privado
  • Durango 34000 Mexico
  • Hospital Civil Fray Antonio Alcalde
  • Guadalajara 44280 Mexico
  • Investigación Biomedica para el desarrollo de Farmacos, S.A. de C.V.
  • Guadalajara 45030 Mexico
  • Hospital Aranda de la Parra S.A. de C.V.
  • Leon 37000 Mexico
  • Urología Multidisciplinaria S.C.
  • Mexico City 11950 Mexico
  • Centro Medico Nacional Siglo XXI IMSS
  • Mexico 06720 Mexico
  • Instituto Nacional de Cancerologia
  • Mexico 14080 Mexico
  • Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubirán
  • Mexico 14080 Mexico
  • Mexico Centre for Clinical Research, S.A. de C.V.
  • Mexico 3100 Mexico
  • Centro de Investigacion Clinica Chapultepec
  • Morelia 58260 Mexico
  • Hospital Central Militar
  • Naucalpan De Juárez 53950 Mexico
  • Investigacion Biomedica Aplicada de Hidalgo
  • Pachuca 42090 Mexico
  • Centro Oncologico Estatal ISSEMYM
  • Toluca 50180 Mexico
  • Consultorio Medico
  • Zapopan 45040 Mexico
  • Uniwersytecki Szpital Kliniczny Bialystok Klinika Urologii
  • Bialystok 15-276 Poland
  • Przychodnia Srodmiescie SP. z o.o.
  • Bydgoszcz 85-080 Poland
  • Szpital Uniwersytecki Nr 2 w Bydgoszczy
  • Bydgoszcz 85-168 Poland
  • Malopolskie Centrum Medyczne
  • Krakow 30-510 Poland
  • Szpital Specjalista Sp. z o.o
  • Kutno 99-300 Poland
  • Dermed Centrum Medyczne Sp. z o.o
  • Lodz 90-265 Poland
  • Wojewódzki Szpital Specjalistyczny im. Stefana Kardynała Wyszyńskiego
  • Lublin 20-718 Poland
  • Urologica Praktyka Lekarska Adam Marcheluk
  • Siedlce 08-110 Poland
  • ZOZ Szpitala Powiatowego w Sochaczewie
  • Sochaczew 96-500 Poland
  • Szpital Św. Elżbiety Mokotowskie Centrum Medyczne
  • Warszawa 02-616 Poland
  • Miedzyleski Szpital Specjalistyczny
  • Warszawa 04-749 Poland
  • Uromedica Wojciech Kolaczyk
  • Wroclaw 52-210 Poland
  • Baia Mare Emergency County Hospital
  • Baia-Mare 430031 Romania
  • Hyperclinica Medlife Grivita
  • Bucharest 010719 Romania
  • Fundeni Clinical Institute, Center for Uronephrology and Renal Transplantation
  • Bucharest 022328 Romania
  • Prof. Dr. Theodor Burghele Clinical Hospital
  • Bucharest 050659 Romania
  • Prof. Dr. Theodor Burghele Clinical Hospital
  • Bucharest 050659 Romania
  • Medisprof SRL
  • Cluj-Napoca 400058 Romania
  • SC Oncolab SRL
  • Craiova 200385 Romania
  • Spitalul Clinic Judetean Mures
  • Targu Mures 540141 Romania
  • Spitalul Clinic Municipal de Urgenta Timisoara
  • Timisoara 300594 Romania
  • Altai Regional Oncology Dispensary
  • Barnaul 656049 Russian Federation
  • Ivanovo Regional Oncology Dispensary
  • Ivanovo 153040 Russian Federation
  • FSBSI 'N. N. Blokhin Russian Cancer Research Center'
  • Moscow 115478 Russian Federation
  • Federal Scientific Clinical Center of Specialized Medical Care Medical Technologies FMBA
  • Moscow 115682 Russian Federation
  • Russian Scientific Center of Roentgenoradiology
  • Moscow 117997 Russian Federation
  • European Medical Center
  • Moscow 123104 Russian Federation
  • Moscow City Clinical Hospital # 62
  • Moscow 125130 Russian Federation
  • Botkin City Clinical Hospital
  • Moscow 125284 Russian Federation
  • Hertzen Oncology Research Institute
  • Moscow 125284 Russian Federation
  • Scientific Clinical Center ''RZD''
  • Moscow 125315 Russian Federation
  • Semashko Regional Clinical Hospital
  • Nizhny Novgorod 603126 Russian Federation
  • National Medical Radiological Research Center
  • Obninsk 249036 Russian Federation
  • Clinical Oncology Dispansary
  • Omsk 644013 Russian Federation
  • LLC Novaya Clinica
  • Pyatigorsk 357500 Russian Federation
  • Pyatigorsky Oncology Dispensary
  • Pyatigorsk 357502 Russian Federation
  • Hospital for War Veterans
  • Rostov-On-Don 344037 Russian Federation
  • Regional Clinical Oncology Dispensary
  • Ryazan 390011 Russian Federation
  • Leningrad Regional Oncology Dispensary
  • Saint-Petersburg 191104 Russian Federation
  • Republican Oncology Dispensary
  • Saransk 430032 Russian Federation
  • Regional Oncology Dispansary #2
  • Saratov 410053 Russian Federation
  • Oncologic Dispensary No.2
  • Sochi 354057 Russian Federation
  • St. Petersburg GBUZ City Hospital # 26
  • St Petersburg 196247 Russian Federation
  • Russian Scientific Center of Radiology and Surgical Technologies
  • St Petersburg 197758 Russian Federation
  • Komi Republic Oncology dispensary
  • Syktyvkar 167904 Russian Federation
  • Tambov Regional Oncology Clinical Dispansary
  • Tambov 392013 Russian Federation
  • Tomsk Regional Oncology Dispensary
  • Tomsk 634050 Russian Federation
  • Multifunctional clinical medical center 'Medical city'
  • Tyumen 625041 Russian Federation
  • Bashkiria State Medical University
  • Ufa 450000 Russian Federation
  • Vologda Regional Oncological Dispensary
  • Vologda 160012 Russian Federation
  • Fund. Puigvert
  • Barcelona 8025 Spain
  • Hosp. Reina Sofia
  • Cordoba 14004 Spain
  • Hospital Jerez De La Frontera
  • Jerez De La Frontera 11407 Spain
  • Hosp. Clinico San Carlos
  • Madrid 28040 Spain
  • Hosp. Univ. 12 de Octubre
  • Madrid 28041 Spain
  • Hosp. Univ. La Paz
  • Madrid 28046 Spain
  • Hospital Universitario Madrid Sanchinarro
  • Madrid 28050 Spain
  • Hosp. Univ. Infanta Sofia
  • Madrid 28702 Spain
  • Hosp. Univ. Fundacion Alcorcon
  • Madrid 28922 Spain
  • Clinica Univ. de Navarra
  • Pamplona 31008 Spain
  • Kliniska Prövningsenheten Urologmottagningen
  • Göteborg 413 45 Sweden
  • Urologiska Mottagningen
  • Malmö 205 02 Sweden
  • Urologiska kliniken
  • Stockholm 118 83 Sweden
  • Urologkliniken
  • Stockholm 171 76 Sweden
  • Urologkliniken
  • Umeå 901 85 Sweden
  • Urologiska kliniken
  • Uppsala 751 85 Sweden
  • Kirurgkliniken
  • Växjö 351 88 Sweden
  • Urologkliniken
  • Örebro 701 85 Sweden
  • Ankara University Medical Faculty
  • Ankara 06100 Turkey
  • Hacettepe University Medical Faculty
  • Ankara 06100 Turkey
  • Dışkapı Yıldırım Beyazıd Training and Research Hospital
  • Ankara 06110 Turkey
  • Gazi University Medical Faculty
  • Ankara 06560 Turkey
  • Ataturk Training and Research Hospital
  • Ankara 06800 Turkey
  • Trakya University Medical Faculty
  • Edirne 22030 Turkey
  • Istanbul University Cerrahpasa Medical Faculty
  • Istanbul 34098 Turkey
  • Ege Universitesi Tip Fakultesi
  • İzmir 35040 Turkey
  • Izmır Medical Park Hospital
  • İzmir 35580 Turkey
  • Mersin University Medical Faculty
  • Mersin 33343 Turkey
  • Cherkassy Regional Oncology Dispensary, Department of Hematology
  • Cherkasy 18009 Ukraine
  • Bukovinian State medical University, Chernivtsi regional clinical Hospital
  • Chernivtsi 58002 Ukraine
  • Dnipropetrovsk State Medical Academy, Dnipropetrovk State Clinical Hospital NA Mechnikov I.I.
  • Dnipo 49005 Ukraine
  • Dnipropetrovsk State Medical Academy, Dnipropetrovsk City Multifield Clinical Hospital # 4
  • Dnipo 49102 Ukraine
  • Ivano Frankivsk National Medical University
  • Ivano-Frankivsk 76008 Ukraine
  • Regional Clinical Center of Urology and Nephrology n.a. V.I. Shapoval
  • Kharkiv 61037 Ukraine
  • Municipal non-profit enterprise 'Regional Center of Oncology'
  • Kharkiv 61070 Ukraine
  • Khmelnitckiy regional hospital
  • Khmelnytsky 29000 Ukraine
  • Main military medical clinical centre
  • Kyiv 01133 Ukraine
  • Kyiv City Clinical Hospital #3
  • Kyiv 02660 Ukraine
  • State Institution National Cancer Institute
  • Kyiv 03022 Ukraine
  • State Institution Institute of Urology NAMS of Ukraine based on Kyiv City Clinical Oncology Center
  • Kyiv 03115 Ukraine
  • Lviv Clinical Regional Hospital
  • Lviv 79010 Ukraine
  • Lviv State Regional Oncology Medical and Diagnostic Center
  • Lviv 79031 Ukraine
  • Municipal institution 'City clinical hospital #10'
  • Odesa 65074 Ukraine
  • Ukrainian Medical Stomatological Academy
  • Poltava 36024 Ukraine
  • Municipal Oncology Centre of Uzhgorod Central Municipal Clinical Hospitlal
  • Uzhgorod 88000 Ukraine
  • Vinnitsa clinical oncology dispensary
  • Vinnitsa 21029 Ukraine
  • Zaporizhzhia medical Academy of postgraduate education, Zaporizhzhia Regoinal Clinical Hospital
  • Zaporizhzhya 69600 Ukraine
  • Cumberland Infirmary
  • Carlisle Ca2 7hy United Kingdom
  • Nhs Tayside
  • Dundee DD2 1UB United Kingdom
  • Beatson West Of Scotland Cancer Centre
  • Glasgow G12 0yn United Kingdom
  • Sarah Cannon Research Institute
  • London W1G 6AD United Kingdom
  • Freeman Hospital
  • Newcastle Upon Tyne NE7 7DN United Kingdom
  • Churchill Hospital
  • Oxford Ox3 7lq United Kingdom
  • Derriford Hospital
  • Plymouth PL6 8qh United Kingdom
  • Scunthorpe General Hospital
  • Scunthorpe DN15 7BH United Kingdom
  • University Hospital of North Tees
  • Stockton On Tees TS19 8PE United Kingdom
  • New Cross Hospital
  • Wolverhampton WV10 0QP United Kingdom

View trial on ClinicalTrials.gov