ATLAS: A Randomized, Double-blind, Placebo-controlled Phase 3 Study of JNJ-56021927 in Subjects With High-risk, Localized or Locally Advanced Prostate Cancer Receiving Treatment With Primary Radiation Therapy


Condition: Prostatic Neoplasms

Intervention:

  • Drug: Apalutamide
  • Drug: Bicalutamide
  • Drug: Bicalutamide Placebo
  • Drug: Apalutamide Placebo
  • Drug: GnRH (agonist)
  • Radiation: 74-80 Grays (units of radiation)

Purpose: The purpose of this study is to determine if apalutamide plus gonadotropin releasing hormone (GnRH) agonist in participants with high-risk, localized or locally advanced prostate cancer receiving primary radiation therapy results in an improvement of metastasis-free survival.

Study Type: Interventional

Clinical Trials Identifier NCT 8-digits: NCT02531516

Sponsor: Aragon Pharmaceuticals, Inc.

Primary Outcome Measures:

  • Measure: Metastasis-free survival
  • Time Frame: 84 Months
  • Safety Issue:

Secondary Outcome Measures:

  • Measure: Time to Local-regional Recurrence
  • Time Frame: 84 Months
  • Safety Issue:
  • Measure: Time to Castration-resistant Prostate Cancer (CRPC)
  • Time Frame: 84 Months
  • Safety Issue:
  • Measure: Time to Distant Metastasis
  • Time Frame: 84 Months
  • Safety Issue:
  • Measure: Overall Survival (OS)
  • Time Frame: 84 Months
  • Safety Issue:

Estimated Enrollment: 1500

Study Start Date: November 19, 2015

Phase: Phase 3

Eligibility:

  • Age: minimum 18 Years maximum N/A
  • Gender: Male

Inclusion Criteria:

  • Age >= 18 years
  • Indicated and planned to receive primary radiation therapy for prostate cancer
  • Histologically confirmed adenocarcinoma of an intact prostate, and 1 of the following at diagnosis: 1) Gleason score >=8 and >=cT2c, 2) Gleason score >=7, PSA >=20 nanogram per milliliters (ng/mL), and >=cT2c
  • Charlson index (CCI) <=3
  • An Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) grade of 0 or 1
  • Adequate organ function: (1) aspartate aminotransferase (AST), alanine aminotransferase (ALT), within normal limits (WNL), (2) serum creatinine less than (<) 1.5 milligram/deciliter (mg/dL) (<133 micromoles/Liter [mcmol/L]), (3) platelets greater than or equal to (>=)140,000/microLiter (mcL), independent of transfusion and/or growth factors within 3 months prior to randomization, (4) Hemoglobin >= 12.0 gram/deciliter (g/dL) (7.4 millimloes [mmol], independent of transfusion and/or growth factors within 3 months prior to randomization
  • Participants who are sexually active (even men with vasectomies) and willing to use a condom and agree not to donate sperm during the trial
  • Signed, written, informed consent
  • Be able to swallow whole study drug tablets

Exclusion Criteria:

  • Presence of distant metastasis, (clinical stage M1). Isolated pelvic nodal disease below the iliac bifurcation (clinical stage N1) is not an exclusion. Diagnosis of distant metastasis (clinical M stage; M0 versus M1a, M1b, M1c) and pelvic nodal disease (clinical N stage; N1 versus N0) will be assessed by central radiological review. Patients are considered eligible only if the central radiological review confirms clinical stage M0.
  • Prior treatment with gonadotropin releasing hormone (GnRH) analogue or anti-androgen or both for >3 months prior to randomization
  • Bilateral orchiectomy
  • History of pelvic radiation
  • Prior systemic (example [e.g.], chemotherapy) or local (e.g. radical prostatectomy, cryotherapy) treatment for prostate cancer
  • History of seizure or any condition that may predispose to seizure (including, but not limited to prior stroke, transient ischemic attack or loss of consciousness <= 1 year prior to randomization; brain arteriovenous malformation; or intracranial masses such as schwannomas and meningiomas that are causing edema or mass effect)
  • Prior treatment with enzalutamide, abiraterone acetate, orteronel, galeterone, ketoconazole, aminoglutethimide, estrogens, megestrol acetate, and progestational agents (including cyproterone acetate) for prostate cancer
  • Prior treatment with radiopharmaceutical agents (e.g., strontium-89) or immunotherapy (e.g., sipuleucel-T) for prostate cancer
  • Prior treatment with systemic glucocorticoids ≤4 weeks prior to randomization or is expected to require long-term use of corticosteroids during the study
  • Use of 5-alpha reductase inhibitors (e.g., dutasteride, finasteride) <=4 weeks prior to randomization
  • Use of any investigational agent <=4 weeks prior to randomization
  • Current chronic use of opioid analgesics for >=3 weeks for oral or >7 days for non-oral formulations
  • Major surgery <=4 weeks prior to randomization
  • Current or prior treatment with anti-epileptic medications for the treatment of seizures
  • Gastrointestinal conditions affecting absorption
  • Known or suspected contraindications or hypersensitivity to apalutamide, bicalutamide or GnRH agonists or any of the components of the formulations
  • Any condition for which, in the opinion of the investigator, participation would not be in the best interest of the subject

Contact:

  • Use link at the bottom of the page to see if you qualify for an enrolling site (see list). If you still have questions:

Locations:

  • Urology Centers Of Alabama
  • Homewood Alabama 35209 United States
  • Ironwood Cancer and Research Center
  • Chandler Arizona 85224 United States
  • 21st Century Oncology
  • Scottsdale Arizona 85251 United States
  • Arizona Institute of Urology
  • Tucson Arizona 85704 United States
  • El Dorado Urology & Prostate Center
  • Tucson Arizona 85715 United States
  • Urological Associates of Southern Arizona, P.C.
  • Tucson Arizona 85741 United States
  • CBCC Global Research
  • Bakersfield California 93309 United States
  • Cedars-Sinai Medical Center
  • Los Angeles California 90048 United States
  • Tower Urology
  • Los Angeles California 90048 United States
  • VA West Los Angeles Medical Center
  • Los Angeles California 90073 United States
  • University of California, Irvine
  • Orange California 92868 United States
  • San Bernardino Urological Associates
  • San Bernardino California 92404 United States
  • Genesis Research
  • San Diego California 92123 United States
  • California Pacific Medical Center
  • San Francisco California 94115 United States
  • University of California San Francisco, Mission Bay Medical Center
  • San Francisco California 94158 United States
  • University of Colorado
  • Aurora Colorado 80045 United States
  • The Urology Center of Colorado
  • Denver Colorado 80211 United States
  • CT Clinical Research Center
  • Middlebury Connecticut 6762 United States
  • Manatee Medical Research Center
  • Bradenton Florida 34205 United States
  • Atlantic Urology Associates
  • Daytona Beach Florida 32114 United States
  • 21st Century Oncology
  • Fort Myers Florida 33908 United States
  • Urology Specialists LLC
  • Hialeah Florida 33002 United States
  • 21st Century Oncology
  • Lakewood Ranch Florida 34202 United States
  • 21st Century Oncology
  • Naples Florida 34102 United States
  • 21st Century Oncology
  • Plantation Florida 33324 United States
  • Saint Alphonsus Regional Medical Center- Cancer Care Center
  • Boise Idaho 83706 United States
  • Idaho Urologic Institute
  • Meridian Idaho 83642 United States
  • Research by Design, LLC
  • Evergreen Park Illinois 60805 United States
  • Monroe Medical Associates Ingalls
  • Harvey Illinois 60426 United States
  • First Urology
  • Jeffersonville Indiana 47130 United States
  • Wichita Urology Group
  • Wichita Kansas 67226 United States
  • Ashland-Bellfonte Cancer Center
  • Ashland Kentucky 41101 United States
  • University of Kentucky Medical Center
  • Lexington Kentucky 40536 United States
  • Tulane University, Office of Clinical Research
  • New Orleans Louisiana 70112 United States
  • Regional Urology
  • Shreveport Louisiana 71106 United States
  • New England Cancer Specialists
  • Scarborough Maine 4074 United States
  • University of Maryland
  • Baltimore Maryland 21201 United States
  • Chesapeake Urology Research Associates
  • Owings Mills Maryland 21117 United States
  • Massachusetts General
  • Boston Massachusetts 2114 United States
  • 21st Century Oncology
  • Farmington Hills Michigan 48334 United States
  • Washington University of St Louis- Alvin J Siteman Cancer Center
  • Saint Louis Missouri 63110 United States
  • Morristown Medical Center
  • Morristown New Jersey 7960 United States
  • The Urological Institute of Northeastern New York
  • Albany New York 12208 United States
  • Montefiore Medical Center
  • Bronx New York 10461 United States
  • Brooklyn Urology Research Group
  • Brooklyn New York 11201 United States
  • AccuMed Research Associates
  • Garden City New York 11530 United States
  • NYU University Urology
  • New York New York 100016 United States
  • Premier Medical Group
  • Poughkeepsie New York 12601 United States
  • University of Rochester Medical Center
  • Rochester New York 14642 United States
  • Associated Medical Professionals
  • Syracuse New York 13210 United States
  • Cary Urology PA
  • Cary North Carolina 27511 United States
  • University of North Carolina
  • Chapel Hill North Carolina 27599 United States
  • Alliance Urology Specialists
  • Greensboro North Carolina 27403 United States
  • Associated Urologists of North Carolina
  • Raleigh North Carolina 27612 United States
  • Coastal Carolina Radiation Oncology
  • Wilmington North Carolina 28401 United States
  • TriState Urologic Services PSC Inc. DBA The Urology Group
  • Cincinnati Ohio 45212 United States
  • University Hospitals Case Medical Center
  • Cleveland Ohio 44106 United States
  • Signal Point Hematology Oncology
  • Middletown Ohio 45042 United States
  • Oregon Health & Science University
  • Portland Oregon 97239-3098 United States
  • Oregon Urology Institute
  • Springfield Oregon 97477 United States
  • Urologic Consultants of SE PA
  • Bala-Cynwyd Pennsylvania 19004 United States
  • Urology Health Specialists, LLC
  • Bryn Mawr Pennsylvania 19010 United States
  • Lancaster Urology
  • Lancaster Pennsylvania 17604 United States
  • Thomas Jefferson University
  • Philadelphia Pennsylvania 19107 United States
  • Omega Medical Research
  • Warwick Rhode Island 02886 United States
  • Charleston Hematology Oncology
  • Charleston South Carolina 29414 United States
  • Carolina Urologic Research Center
  • Myrtle Beach South Carolina 29572 United States
  • Urology Associates
  • Nashville Tennessee 37209 United States
  • Vanderbilt University
  • Nashville Tennessee 37235 United States
  • Urology Clinics of North Texas
  • Dallas Texas 75231 United States
  • Texas Oncology P.A.
  • Houston Texas 77024 United States
  • Houston Metro Urology
  • Houston Texas 77027 United States
  • Houston Methodist Cancer Center
  • Houston Texas 77030 United States
  • Urology San Antonio Research
  • San Antonio Texas 78229 United States
  • INOVA Dwiight &Martha Schar Cancer Institute
  • Fairfax Virginia 22031 United States
  • Sentara Rockingham Memorial Hospital Hahn Cancer Center
  • Harrisonburg Virginia 22801 United States
  • Urology of Virginia, PLCC
  • Virginia Beach Virginia 23462 United States
  • Seattle Urology Research Center
  • Burien Washington 98166 United States
  • Medical Oncology Associates, PS
  • Spokane Washington 99208-1129 United States
  • West Virginia University Medical Center
  • Morgantown West Virginia 26506 United States
  • Instituto Medico Alexander Fleming
  • C.a.b.a. C1426ANZ Argentina
  • Hospital Militar Cosme Argerich
  • C.a.b.a. C1426BOR Argentina
  • Centro de Urologia (CDU)
  • Caba C1120AAT Argentina
  • Fundación CENIT para la Investigación en Neurociencias
  • Capital Federal CP 1125 Argentina
  • Fundacion Favaloro
  • Ciudad Autonoma De Buenos Aires C1093AAS Argentina
  • Centro de Investigacion Pergamino SA
  • Pergamino B2700CPM Argentina
  • Sanatorio Britanico de Rosario
  • Rosario 2000 Argentina
  • Instituto de Oncologia de Rosario (IOR)
  • Rosario S2000KZE Argentina
  • ARS Médica
  • San Salvador De Jujuy Y4600AFW Argentina
  • Clínica Viedma
  • Viedma R8500ACE Argentina
  • OLV Ziekenhuis Aalst
  • Aalst 9300 Belgium
  • Imelda Bonheiden
  • Bonheiden 2820 Belgium
  • UCL St Luc
  • Brussel B-1200 Belgium
  • Jolimont
  • Haine-St-Paul 7100 Belgium
  • UZ Leuven
  • Leuven 3000 Belgium
  • Sart Tilman
  • Liège 4000 Belgium
  • Clinique et Maternité Sainte Elisabeth
  • Namur 5000 Belgium
  • Algemeen Ziekenhuis Delta
  • Roeselare 8800 Belgium
  • AZ Nikolaas
  • Sint-Niklaas 9100 Belgium
  • AZ Turnhout
  • Turnhout 2300 Belgium
  • GZA Ziekenhuis
  • Wilrijk 2610 Belgium
  • Fundacao Pio Xii - Hospital De Cancer De Barretos
  • Barretos 14784-400 Brazil
  • Cetus Oncologia
  • Belo Horizonte 30150-270 Brazil
  • Instituto Mario Penna
  • Belo Horizonte 30380-472 Brazil
  • Instituto do Radium de Campinas Ltda.
  • Campinas 13075-460 Brazil
  • Hospital Erasto Gaertner
  • Curitiba 81520-060 Brazil
  • Centro de Pesquisas Oncológicas - CEPON
  • Florianópolis 88034-000 Brazil
  • Hospital Araújo Jorge da Associação de Combate ao Câncer em Goiás
  • Goiânia 74605-070 Brazil
  • Hospital de Caridade de Ijui - CACON
  • Ijui 98700-000 Brazil
  • Liga Norte Riograndense Contra O Cancer
  • Natal 59075-740 Brazil
  • Irmandade Santa Casa de Misericordia de Porto Alegre
  • Porto Alegre 90020-090 Brazil
  • IRPCC - Instituto Ribeiraopretano de Combate ao Cancer
  • Ribeirao Preto 14015-130 Brazil
  • Instituto Nacional do Cancer - INCA
  • Rio De Janeiro 20231-050 Brazil
  • Hospital Universitário Pedro Ernesto
  • Rio De Janeiro 20551-030 Brazil
  • Instituto COI de Pesquisa, Educação e Gestão
  • Rio De Janeiro 22793-080 Brazil
  • Hospital Santa Isabel
  • Salvador 40050-410 Brazil
  • Núcleo de Oncologia da Bahia
  • Salvador 42700-000 Brazil
  • CEPHO - Centro de Estudos e Pesquisa de Hematologia e Oncologia
  • Santo André 09060-650 Brazil
  • Fundacao Faculdade Regional De Medicina De Sao Jose Do Rio Preto
  • Sao Jose Do Rio Preto 15090-000 Brazil
  • Centro de Pesquisa do Instituto do Cancer Arnaldo Vieira de Carvalho
  • Sao Paulo 01221-020 Brazil
  • Santa Casa de Misericordia de São Paulo
  • Sao Paulo 01221-020 Brazil
  • IBCC Instituto Brasileiro de Controle do Cancer
  • Sao Paulo 03102-002 Brazil
  • Hospital Santa Marcelina
  • Sao Paulo 08270-070 Brazil
  • Centro de Estudos e Pesquisas Oncologicas de Sorocaba (Instituto de Oncologia de Sorocaba)
  • Sorocaba 18030-075 Brazil
  • Sociedade Hospital Samaritano
  • São Paulo 01232-010 Brazil
  • Instituto de Estudo e Pesquisa Sao Lucas
  • São Paulo 01236-030 Brazil
  • ICESP - Instituto do Câncer do Estado de São Paulo
  • São Paulo 01246-000 Brazil
  • Hospital Sirio Libanes
  • São Paulo 01308-050 Brazil
  • Fundação Antônio Prudente - A.C. Camargo Cancer Center
  • São Paulo 01509-900 Brazil
  • Instituto de Assistência Médica ao Servidor Público Estadual - HSPE-FMO
  • São Paulo 04039-004 Brazil
  • Hospital Israelita Albert Einstein
  • São Paulo 05651-900 Brazil
  • Tom Baker Cancer Center, University of Calgary
  • Calgary Alberta T2N 4N2 Canada
  • BC Cancer Agency, Fraser Valley Cancer Centre (FVCC)
  • Surrey British Columbia V3V 1Z2 Canada
  • British Columbia Cancer Agency (BCCA) - Vancouver Centre
  • Vancouver British Columbia V5Z 4E6 Canada
  • British Columbia Cancer Agency - Vancouver Island Centre
  • Victoria British Columbia V8R 6V5 Canada
  • Doctor H. Bliss Murphy Cancer Centre
  • St. John'S Newfoundland and Labrador A1B 3V6 Canada
  • Cancer Centre of Southeastern Ontario (Kingston Regional Cancer Centre)
  • Kingston Ontario K7L 5P9 Canada
  • London Health Sciences Centre
  • London Ontario N6A 4L6 Canada
  • The Ottawa Hospital Cancer Centre
  • Ottawa Ontario K1H 8L6 Canada
  • Sunnybrook Health Sciences Center
  • Toronto Ontario M4N 3M5 Canada
  • Princess Margaret Cancer Centre
  • Toronto Ontario M5G 2M9 Canada
  • CISSS de l'Outaouais
  • Gatineau Quebec J8P 7H2 Canada
  • Hopital de la Cite de la Sante - Centre integre de cancerologie de Laval (CICL)
  • Laval Quebec H7M 3L9 Canada
  • McGill University - Jewish General Hospital
  • Montreal Quebec H3T 1E2 Canada
  • Hopital Maisonneuve-Rosemont
  • Montréal Quebec H1T 2M4 Canada
  • CHUM - Centre hospitalier universitaire de Montreal
  • Montréal Quebec H2X 3E4 Canada
  • Centre Hospitalier Universitaire de Sherbrooke
  • Sherbrooke Quebec J1H 5N4 Canada
  • Allan Blair Cancer Centre, Paqua Hospital
  • Regina Saskatchewan S4T 7T1 Canada
  • Saskatoon Cancer Centre at the University of Saskatchewan
  • Saskatoon Saskatchewan S7N 4H4 Canada
  • CHUQ - CHU de Quebec
  • Quebec G1R 2J6 Canada
  • Peking University First Hospital
  • Beijing 100034 China
  • Beijing Friendship Hospital
  • Beijing 100050 China
  • Peking University Third Hospital
  • Beijing 100083 China
  • Beijing Cancer Hospital of Peking University
  • Beijing 100142 China
  • Beijing Hospital
  • Beijing 100730 China
  • Peking Union Medical College Hospital
  • Beijing 100730 China
  • Hunan Cancer hospital
  • Changsha 410013 China
  • The people's Hospital of Sichuan Province
  • Chengdu 610072 China
  • Chongqing Cancer hospital
  • Chongqing 400030 China
  • Sun Yat-Sen University Cancer Center
  • Guangzhou 430030 China
  • Guangzhou First Municipal People's Hospital
  • Guangzhou 510180 China
  • The Second Affiliated Hospital of Zhejiang University
  • Hangzhou 310009 China
  • Zhejiang Cancer Hospital
  • Hangzhou 310015 China
  • The First Affliated Hospital Of Nanchang University
  • Nanchang 330006 China
  • Jiangsu Cancer Hospital
  • Nanjing 210000 China
  • Nanjing Drum Tower Hospital
  • Nanjing 210008 China
  • Drug clinical trial ethics committee of Ningbo First Hospital
  • Ningbo 315010 China
  • Fudan University Shanghai Cancer Center
  • Shanghai 200032 China
  • Shanghai Zhongshan Hospital
  • Shanghai 200032 China
  • ShangHai Huadong Hospital
  • Shanghai 200040 China
  • Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
  • Shanghai 200092 China
  • ShangHai Changhai Hospital
  • Shanghai 200433 China
  • Shanghai No. 1 Hospital
  • Shanghai 201620 China
  • First Hospital of Shanxi Medical University
  • Taiyuan 030001 China
  • Wuhan Tongji Hospital, Tongji Medical College
  • Wuhan 430030 China
  • First Affiliated Hospital, Xi'an Jiaotong University
  • Xi'An 710004 China
  • Fakultní nemocnici Brno
  • Brno 625 00 Czechia
  • Fakultni nemocnice Hradec Kralove
  • Hradec Králove 500 05 Czechia
  • Krajská nemocnice Liberec
  • Liberec 460 63 Czechia
  • Nemocnice Novy Jicin a.s., oddeleni radioterapie a onkologie
  • Nový Jicin 741 01 Czechia
  • Uromedical Center s.r.o.
  • Olomouc 77900 Czechia
  • Slezska nemocnice v Opave
  • Opava 746 01 Czechia
  • Onkologicke Centrum Multiscan
  • Pardubice 532 03 Czechia
  • Fakultni nemocnice Kralovske Vinohrady
  • Praha 10 100 34 Czechia
  • Urocentrum Praha
  • Praha 2 120 00 Czechia
  • Urologicka klinika 1.LF UK a VFN
  • Praha 2 120 00 Czechia
  • Thomayerova nemocnice
  • Praha 4 140 59 Czechia
  • Urologicka klinika 2.LF UK a FN Motol
  • Praha 5 150 00 Czechia
  • Nemocnice Na Bulovce
  • Praha 8 180 00 Czechia
  • Krajska Nemocnice T. Bati a.s. (KNTB) - Ambulance Urologicka
  • Zlin 762 75 Czechia
  • Clinique de l'Europe
  • Amiens 80090 France
  • Institut de Cancerologie de Ouest (ICO) Site Paul Papin
  • Angers Cedex 02 49055 France
  • Institut Sainte Catherine
  • Avignon Cedex 9 84918 France
  • Centre d'Oncologie et de Radiothérapie du Pays Basque
  • Bayonne 64100 France
  • CHRU De Besancon
  • Besancon 25030 France
  • Institut Bergonié
  • Bordeaux 33000 France
  • CHU Brest
  • Brest 29200 France
  • Centre d'oncologie et de radiothérapie du Parc
  • Dijon 21000 France
  • Centre Georges François Leclerc
  • Dijon 21000 France
  • Clinique Sainte Marguerite
  • Hyères 83400 France
  • Clinique Universitaire de cancérologie-Radiothérapie
  • La Tronche 38700 France
  • Centre Jean Bernard - Clinique Victor Hugo
  • Le Mans 72000 France
  • Centre Oscar Lambret
  • Lille 59020 France
  • Hopital La Timone
  • Marseille Cedex 05 13385 France
  • Hôpital Privé Clairval
  • Marseilli 13009 France
  • Institut Regional du Cancer de Montpellier Val d'Aurelle
  • Montpellier 34298 France
  • Hôpital Américain de Paris
  • Neuilly-Sur-Seine 92200 France
  • Hopital Privé des Peupliers
  • Paris 75013 France
  • Hopital Saint-Louis
  • Paris 75475 France
  • Institut du cancer courlancy
  • Reims 51100 France
  • Centre de radiothérapie et d'Oncologie médicale de l'Essonne
  • Ris Orangis 91130 France
  • Institut de Cancérologie de l'Ouest (ICO)
  • Saint Herblain 44800 France
  • Clinique Armoricaine de Radiologie
  • Saint-Brieuc 22015 France
  • Hôpital d'Instruction des Armées BEGIN
  • Saint-Mandé 94160 France
  • Institut de Cancerologie Lucien Neuwirth
  • Saint-Priest-En-Jarez 42270 France
  • Strasbourg Oncologie Libérale
  • Strasbourg 67000 France
  • Clinique Pasteur
  • Toulouse 31300 France
  • CHRU Tours Hôpital Bretonneau
  • Tours 37000 France
  • Institut de Cancérologie de Lorraine
  • Vandoeuvre-Les-Nancy 54500 France
  • Hôpital Privé Océane
  • Vannes 56000 France
  • Gustave Roussy
  • Villejuif Cedex 94800 France
  • Städtisches Klinikum Braunschweig gGmbH - Standort Salzdahlumer
  • Braunschweig 38126 Germany
  • Zeisigwaldkliniken Bethanien Chemnitz
  • Chemnitz 9130 Germany
  • Diakonissenkrankenhaus Dessau
  • Dessau 6846 Germany
  • Universitatsklinikum Frankfurt
  • Frankfurt 60590 Germany
  • St. Antonius-Hospital Gronau GmbH
  • Gronau 48599 Germany
  • Universitätsklinikum Jena
  • Jena 7743 Germany
  • Klinik und Poliklinik für Urologie
  • Köln 50937 Germany
  • Universitätsklinikum Münster
  • Münster 48149 Germany
  • Studienpraxis Urologie Nürtingen
  • Nürtingen 72622 Germany
  • Gemeinschaftspraxis für Urologie in Traunstein
  • Traunstein 83278 Germany
  • Universitaetsklinikum Ulm
  • Ulm 89081 Germany
  • Klinikum Weiden
  • Weiden 92637 Germany
  • Assaf Harofeh Medical Center
  • Beer Yaakov 73100 Israel
  • Soroka Medical Center
  • Beer-Sheva 84101 Israel
  • Rambam Medical Center
  • Haifa 35254 Israel
  • Hadassah Medical Organization Ein Kerem
  • Jerusalem 91120 Israel
  • Meir Medical Center
  • Kfar Saba 44281 Israel
  • Rabin Medical Center
  • Petach-Tikva 49100 Israel
  • Sheba Medical Center
  • Ramat-Gan 52621 Israel
  • Sourasky (Ichilov) Medical Center
  • Tel-Aviv 64239 Israel
  • Reparto di Radioterapia Centro di Riferimento Oncologico
  • Aviano 33081 Italy
  • Radioterapia Oncologica, A.O.U. San'T Orsola
  • Bologna 40138 Italy
  • Istituto del Radio Olindo Alberti Spedali Civili Brescia
  • Brescia 25123 Italy
  • Istituto Ricerca Contro il Cancro
  • Candiolo 10060 Italy
  • Humanitas Centro Catanese di Oncologia
  • Catania 95126 Italy
  • Azienda Ospedaliero Universitaria Careggi
  • Firenze 50134 Italy
  • Ospedale San Raffaele
  • Milano 20132 Italy
  • Istituto Europeo di Oncologia Servizio Radioterapia
  • Milano 20141 Italy
  • Fondazione IRCCS Istituto Nazionale dei Tumori
  • Napoli 80131 Italy
  • Ospedale Sacro Cuore Negrar-Verona
  • Negrar 37024 Italy
  • U.O.Radioterapia Oncologica, Azienda Ospedaliera Di Perugia
  • Perugia 06156 Italy
  • Irccs Crob
  • Rionero In Vulture 85028 Italy
  • Università Campus Biomedico di Roma
  • Roma 00128 Italy
  • Fondazione Policlinico Tor Vergata
  • Roma 00133 Italy
  • Istituto Regina Elena, Roma
  • Roma 00144 Italy
  • Gemelli Art ,Università Cattolica S.Cuore
  • Roma 00168 Italy
  • Azienda Ospedaliera Sant Andrea
  • Roma 00189 Italy
  • Istituto Clinico Humanitas
  • Rozzano 20089 Italy
  • Kyungpook National University Chilgok Hospital
  • Daegu 41404 Korea, Republic of
  • Chonnam National University Hwasun Hospital
  • Hwasun-Gun 519-809 Korea, Republic of
  • Seoul National University Bundang Hospital
  • Seongnam-Si, Gyeonggi-Do 13620 Korea, Republic of
  • Seoul National University Hospital
  • Seoul 03080 Korea, Republic of
  • Seoul St. Mary's Hospital
  • Seoul 06591 Korea, Republic of
  • Samsung Medical Center
  • Seoul 135 710 Korea, Republic of
  • Ajou University Hospital
  • Suwon 443-721 Korea, Republic of
  • University Kebangsaan Malaysia Medical Centre
  • Cheras 56000 Malaysia
  • Pulau Pinang Hospital
  • Georgetown 10990 Malaysia
  • Hospital University Sains Malaysia
  • Kota Bharu 15600 Malaysia
  • Hospital Kuala Lumpur
  • Kuala Lumpur 50586 Malaysia
  • University Malaya Medical Centre
  • Kuala Lumpur 59100 Malaysia
  • Sarawak General Hospital
  • Kuching 93586 Malaysia
  • National Cancer Institute
  • Putrajaya 62250 Malaysia
  • Centro para el Desarrollo de la Medicina y de Asistencia Médica Especializada S.C. 'SINACOR'
  • Culiacan 80230 Mexico
  • Hospital Civil Fray Antonio Alcalde
  • Guadalajara 44280 Mexico
  • Hospital Aranda de la Parra S.A. de C.V.
  • Leon 37000 Mexico
  • Centro Medico Nacional Siglo XXI IMSS
  • Mexico 06720 Mexico
  • Clinica Lomas Altas
  • Mexico 11950 Mexico
  • Instituto Nacional de Cancerologia
  • Mexico 14080 Mexico
  • Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubirán
  • Mexico 14080 Mexico
  • Centro de Investigacion Clinica Chapultepec
  • Morelia 58260 Mexico
  • Centro Oncologico Estatal ISSEMYM
  • Toluca 50180 Mexico
  • Consultorio Medico
  • Zapopan 45040 Mexico
  • Mc Alkmaar
  • Alkmaar 1815 JD Netherlands
  • NKI-AVL, Amsterdam
  • Amsterdam 1066 CX Netherlands
  • VUMC Amsterdam
  • Amsterdam 1081 HV Netherlands
  • Rijnstate Ziekenhuis
  • Arnhem 6815 AD Netherlands
  • MC Haaglanden
  • Den Haag 2512 VA Netherlands
  • Catharinaziekenhuis
  • Eindhoven 5623 EJ Netherlands
  • Spaarne Gasthuis
  • Hoofddorp 2134 TM Netherlands
  • UMC St. Radboud
  • Nijmegen 6525 GA Netherlands
  • Canisius-Wilhelminaziekenhuis
  • Nijmegen 6532 SZ Netherlands
  • Erasmus MC
  • Rotterdam 3075 EA Netherlands
  • Bialostockie Centrum Onkologii im. Marii Sklodowskiej-Curie w Bialymstoku
  • Bialystok 15-027 Poland
  • Centrum Onkologii im. Prof. F. Lukaszczyka w Bydgoszczy
  • Bydgoszcz 85-796 Poland
  • Szpitale Pomorskie Sp. z o.o.
  • Gdynia 81-519 Poland
  • Centrum Onkologii - Instytut im. Marii Sklodowskiej-Curie w Gliwicach
  • Gliwice 44-101 Poland
  • Swietokrzyskie Centrum Onkologii SPZOZ w Kielcach
  • Kielce 25-734 Poland
  • Wojewodzki Szpital Specjalistyczny im. M. Kopernika w Lodzi
  • Lodz 93-513 Poland
  • SPZOZ Ministerstwa Spraw Wewnętrznych z Warminsko-Mazurskim Centrum Onkologii w Olsztynie
  • Olsztyn 10-228 Poland
  • Wielkopolskie Centrum Onkologii im. Marii Skłodowskiej-Curie w Poznaniu
  • Poznan 61-866 Poland
  • Affidea Onkoterapia Sp z o.o.- Miedzynarodowe Centrum Onkologii
  • Walbrzych 58-309 Poland
  • Institutul Oncologic Prof.Dr.Al.Trestioreanu Bucuresti
  • Bucuresti 022328 Romania
  • Institut Clinic Fundeni
  • Bucuresti 22328 Romania
  • Institut Clinic Fundeni
  • Bucuresti 22328 Romania
  • Prof. Dr. Theodor Burghele Clinical Hospital
  • Bucuresti 50659 Romania
  • Institutul Oncologic 'Prof Dr. Ion Chiricuta' Cluj-Napoca
  • Cluj-Napoca 400015 Romania
  • Medisprof SRL
  • Cluj-Napoca 400058 Romania
  • Radiotherapy Center Cluj
  • Floresti 407280 Romania
  • Institutul Regional de Oncologie Iasi
  • Iasi 700483 Romania
  • RTC Radiology Therapeutic Center
  • Otopeni 75100 Romania
  • Spital Municipal Ploiesti
  • Ploiesti 100337 Romania
  • Spitalul Clinic Judetean Sibiu
  • Sibiu 550245 Romania
  • SC. Clinica Polisano SRL
  • Sibiu 550253 Romania
  • Spitalul Clinic Judetean Mures
  • Targu Mures 540141 Romania
  • Spitalul Clinic Municipal de Urgenta Timisoara
  • Timisoara 300594 Romania
  • Altai Regional Oncology Dispensary
  • Barnaul 656049 Russian Federation
  • Ivanovo Regional Oncology Dispensary
  • Ivanovo 153040 Russian Federation
  • FSBSI 'N. N. Blokhin Russian Cancer Research Center'
  • Moscow 115478 Russian Federation
  • Russian Scientific Center of Roentgenoradiology
  • Moscow 117997 Russian Federation
  • Moscow City Clinical Hospital # 62
  • Moscow 125130 Russian Federation
  • Hertzen Oncology Research Institute
  • Moscow 125284 Russian Federation
  • Semashko Regional Clinical Hospital
  • Nizhny Novgorod 603126 Russian Federation
  • National Medical Radiological Research Center
  • Obninsk 249036 Russian Federation
  • Clinical Oncology Dispansary
  • Omsk 644013 Russian Federation
  • LLC Novaya Clinica
  • Pyatigorsk 357500 Russian Federation
  • Hospital for War Veterans
  • Rostov-On-Don 344037 Russian Federation
  • Regional Clinical Oncology Dispensary
  • Ryazan 390011 Russian Federation
  • Leningrad Regional Oncology Dispensary
  • Saint-Petersburg 191104 Russian Federation
  • City Oncology Dispensary
  • Saint-Petersburg 197022 Russian Federation
  • Republican Oncology Dispensary
  • Saransk 430032 Russian Federation
  • Regional Oncology Dispansary #2
  • Saratov 410053 Russian Federation
  • Oncologic Dispensary No.2
  • Sochi 354057 Russian Federation
  • Russian Scientific Center of Radiology and Surgical Technologies
  • St Petersburg 197758 Russian Federation
  • Tambov Regional Oncology Clinical Dispansary
  • Tambov 392013 Russian Federation
  • Multifunctional clinical medical center 'Medical city'
  • Tyumen 625041 Russian Federation
  • Bashkiria State Medical University
  • Ufa 450000 Russian Federation
  • Vologda Regional Oncological Dispensary
  • Vologda 160012 Russian Federation
  • Hosp. Univ. de Cruces
  • Barakaldo 48903 Spain
  • Hosp. Univ. Vall D Hebron
  • Barcelona 08035 Spain
  • Hosp. de La Santa Creu I Sant Pau
  • Barcelona 08041 Spain
  • Fund. Hosp. Prov de Castellon
  • Castellon 12002 Spain
  • Ico Hospitalet (catalan Institute Of Oncology)
  • Hospitalet De Llobregat 8907 Spain
  • Hosp. Univ. de Gran Canaria Dr. Negrin
  • Las Palmas De Gran Canaria 35010 Spain
  • Hosp. Univ. de La Princesa
  • Madrid 28006 Spain
  • Hosp. Univ. Ramon Y Cajal
  • Madrid 28034 Spain
  • Hosp. Univ. 12 de Octubre
  • Madrid 28041 Spain
  • Centro Integral Oncológico Clara Campal
  • Madrid 28050 Spain
  • Hosp. Virgen de La Victoria
  • Málaga 29010 Spain
  • Hosp. Univ. Sant Joan De Reus
  • Reus 43204 Spain
  • Hosp. Clinico Univ. de Santiago
  • Santiago De Compostela 15706 Spain
  • Hosp. Virgen Del Rocio
  • Sevilla 41013 Spain
  • Onkologiska kliniken Radiumhemmet
  • Stockholm 17176 Sweden
  • Urologiska kliniken
  • Umeå 90185 Sweden
  • Urologiska kliniken Örebro
  • Örebro 70185 Sweden
  • Kaohsiung Veterans General Hospital
  • Kaohsiung 81362 Taiwan
  • Chang Gung Memorial Hospital
  • Kaohsiung 83301 Taiwan
  • China Medical University Hospital
  • Taichung 40447 Taiwan
  • National Cheng Kung University Hospital
  • Tainan 70403 Taiwan
  • National Taiwan University Hospital
  • Taipei City 10002 Taiwan
  • Taipei Veterans General Hospital
  • Taipei 11217 Taiwan
  • Chang Gung Memorial Hospital
  • Taoyuan 33305 Taiwan
  • Başkent University Medical Faculty Adana Application and Research Center
  • Adana 01250 Turkey
  • Hacettepe University Medical Faculty
  • Ankara 06100 Turkey
  • Gazi University Medical Faculty
  • Ankara 06560 Turkey
  • Ataturk Training and Research Hospital
  • Ankara 06800 Turkey
  • Trakya University Medical Faculty
  • Edirne 22030 Turkey
  • Istanbul University Cerrahpasa Medical Faculty
  • Istanbul 34098 Turkey
  • Ege Universitesi Tip Fakultesi
  • İzmir 35040 Turkey
  • Izmır Medical Park Hospital
  • İzmir 35580 Turkey
  • Erciyes University Medical Faculty
  • Kayseri 38039 Turkey
  • Kocaeli University Medical Faculty
  • Kocaeli 41380 Turkey
  • Dnipropetrovsk State Medical Academy, Dnipropetrovk State Clinical Hospital NA Mechnikov I.I.
  • Dnipro 49005 Ukraine
  • Dnipropetrovsk State Medical Academy, Dnipropetrovsk City Multifield Clinical Hospital # 4
  • Dnipro 49102 Ukraine
  • Municipal non-profit enterprise 'Regional Center of Oncology'
  • Khakhiv 61070 Ukraine
  • State Institution National Cancer Institute
  • Kyiv 03022 Ukraine
  • State Institution Institute of Urology NAMS of Ukraine based on Kyiv City Clinical Oncology Center
  • Kyiv 03115 Ukraine
  • Lviv Clinical Regional Hospital
  • Lviv 79031 Ukraine
  • Aberdeen Royal Infirmary
  • Aberdeen AB25 2ZB United Kingdom
  • University Hospitals Birmingham NHS Trust,
  • Birmingham B15 2PR United Kingdom
  • Royal Blackburn Hospital
  • Blackburn BB2 3HH United Kingdom
  • Bristol Haematology and Oncology Centre
  • Bristol BS2 8ED United Kingdom
  • Royal Derby Hospital
  • Derby DE22 3NE United Kingdom
  • Beatson West Of Scotland Cancer Centre
  • Glasgow G84 7SSE United Kingdom
  • Churchill Hospital
  • Oxford OX3 7LE United Kingdom
  • Derriford Hospital
  • Plymouth PL6 8qh United Kingdom
  • Lancashire Teaching Hospitals NHS Foundation Trust Royal Preston Hospital
  • Preston PR2 9HT United Kingdom
  • The University Of Sheffield, Weston Park Hospital
  • Sheffield S10 2SJ United Kingdom
  • Royal Marsden Hospital
  • Sutton SM2 5PT United Kingdom
  • New Cross Hospital
  • Wolverhampton WV10 0QP United Kingdom

View trial on ClinicalTrials.gov