Hypoxia and Stem Cell Content as Aggression Factors in Prostate Cancer

Condition: Prostate Cancer

Study Type: Interventional

Clinical Trials Identifier NCT 8-digits: NCT02095249

Sponsor: University Health Network, Toronto


  • Age: minimum 18 Years maximum N/A
  • Gender: Male

Inclusion Criteria:

  • Prostate cancer patients with bulky intermediate risk or high-risk disease who have already agreed to undergo an open radical prostatectomy at Princess Margaret Cancer Centre-UHN:
  • Clinical stage T2-T3 N0 M0
  • Pathology of adenocarcinoma of the prostate AND
  • Gleason score 7 with >/= 50 % biopsies involved with tumour; OR
  • Gleason score 8 or above (any percentage of biopsies)

Exclusion Criteria:

  • Patients with clinical T4, N1 or M1 disease
  • Patients with histologies other than adenocarcinoma
  • Patients unable to ingest pimonidazole tablets

View trial on ClinicalTrials.gov