Carboplatin-gemcitabine Versus Cisplatin-gemcitabine as Neoadjuvant Chemotherapy for Treatment of Muscle Invasive Urinary Bladder Cancer: a Prospective Randomized Trial
Condition: Urinary Bladder Cancer
Study Type: Interventional
Clinical Trials Identifier NCT 8-digits: NCT05822934
Sponsor: Assiut University
Phase: Phase 3
Eligibility:
- Age: minimum 18 Years maximum N/A
- Gender: All
Inclusion Criteria:
- All patients diagnosed with muscle invasive urinary bladder cancer that can receive chemotherapy are included the criteria are
- • Age above 18 years,
- Pathologically proven urinary bladder cancer,
- Patients with clinical stages T2-4a N0-3 M0,
- Patients with good renal and liver functions
- patients with no distant metastases,
- no other malignancy (double malignancy).
- Performance status 0-1 according to ECOG performance status scale.
- Patients with no contraindications for radiotherapy.
Exclusion Criteria:
- • performance status 2-4 according to ECOG performance status scale.
- patients refuse to receive chemotherapy,
- patients not eligible to receive chemotherapy due to liver or renal impairment or thrombocytopenia,
- patients with M1 disease.
View trial on ClinicalTrials.gov