CRPC with Bone Metastases

It Takes A Village: Why It’s Been So Hard to Grow Prostate Cancer Patient-Derived Explants

There are many features that distinguish prostate cancer from other common solid tumors, but one of the more frustrating for researchers has been the difficulty transplanting human tumors into laboratory mice. For most solid tumors, transplantation across species varies in yield, despite the use of immune-incompetent mice and support of various growth factors; but prostate cancer stands out as being of particularly low yield.

The State of Bone Health in mCRPC: ERA-223 Results Revealed

At the 2018 meeting of the European Society of Medical Oncology (ESMO), Matthew Smith, MD, PhD, presented the highly anticipated results of ERA-223, a phase III trial of abiraterone acetate prednisone (AAP) combined with radium-223 or placebo in men with asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC)1. Radium-223 is the alpha-

My Retirement Plan: 401K, IRA, and…..Prostate Cancer Screening?

As a physician, I probably don’t think about my own health as much as you might guess, but last month I underwent an executive physical (full disclosure: my wife signed me up and my Duke benefits covered it, otherwise I would not be talking about this). Labs, physical, stress test, bone and muscle density testing; nutrition, exercise and stress counseling, the whole gamut.

From the Desk of the Editor: Non-Metastatic Metastases and Other Confusing Findings from the PROSPER and SPARTAN Trials

Last month we saw the final published data from the PROSPER study1, and coupled with the earlier published SPARTAN study2, we now have two complete and large phase III studies detailing the clinical activity of androgen-receptor inhibitors, enzalutamide and apalutamide in so-called “non-metastatic” castrate-resistant prostate

From the Desk of the Editor: “Bone Metastases Matter”

For those of us who are responsible for treating men with metastatic castration-resistant prostate cancer (mCRPC), we’ve all seen the ravages that this disease bestows on its victims – bone pain, weakness, anorexia/weight loss, anemia and other cytopenias and fatigue, profound fatigue.

Normally, we can see this coming – both in terms of the symptoms progressing through the last year or year and a half of life, as well as the tumor burden. Until recently, it has been hard to quantify these factors.

Bone is the New Primary - Daniel George

How many times has a patient with advanced prostate cancer said to you, “I have bone cancer?” 

In the past, I would smile politely and correct them by saying, “actually what you have is prostate cancer that has spread to your bones.” But, what if they are right? I mean, many of these patients have previously undergone a prostatectomy or radiation therapy, and have no evidence of local disease. Sure, the patient may have an elevated prostate-specific antigen (PSA) level, but does that alone really make this prostate cancer? 

Understanding treatment options for prostate cancer patients with symptomatic bone metastases

Our ability to offer a multitude of effective therapies for the advanced prostate cancer patient continues forward, enhancing patient outcomes while minimizing quality of life untoward effects. Radium 223 (Xofigo), approved in May 2013, is the most recently approved and efficacious advanced prostate cancer (PCa) treatment, receiving level one guidelines endorsements from AUA, EAU, ASCO, ESMO, and NCCN. This addition of CRPC Bone Metastases: Center of Excellence, highlights 3 important publications, each with novel information which supports the clinician responsible for advanced PCa patients with bone metastases burden, the predominant site of metastatic location with well documented meta-analyses for advanced PCa patients worldwide. 
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