Welcome to the timely new M0 castration-resistant prostate cancer (M0 CRPC) Center of Excellence.

Until February 2018 and the milestone ASCO GU presentations of the Phase III trials, A Study of Apalutamide (ARN-509) in Men With Non-Metastatic Castration-Resistant Prostate Cancer (SPARTAN) and Safety and Efficacy Study of Enzalutamide in Patients With Nonmetastatic Castration-Resistant Prostate Cancer (PROSPER), there did not exist a globally conducted trial demonstrating level one evidence via a randomized, prospective, blinded, placebo controlled protocol whereby an oral pharmacologic agents provided a significant delay in metastases free survival(MFS). In reviewing the AUA castration-resistant prostate cancer (CRPC) index cases and the recommendation for systemic therapeutic intervention, only index Case1, an M0 CRPC patient, lacked level one evidence for any regulatory approved medication.