18F-Fluciclovine PET/CT Scanning in High Risk Primary Prostate Carcinoma - Trond Bogsrud

18F-Fluciclovine PET/CT Scanning in Patients With High Risk Primary Prostate Carcinoma - Trond Bogsrud

(Length of discussion -  10 minutes)

Dr. Trond Bogsrud discusses the performance of the investigational amino acid PET tracer fluciclovine F18 compared to histopathology which was retrospectively evaluated in patients with high risk primary prostate carcinoma to investigate whether fluciclovine F18 PET-CT has utility for disease staging, prior to selection of definitive primary treatment.

He overviews 86 patients with histologically confirmed primary prostate carcinoma who underwent fluciclovine F18 PET-CT scanning, as part of their pre-treatment work up for disease staging at two sites in Norway.

His evaluation of study results supports the utility of Fluciclovine (18F) PET/CT as an aid for the detection of metastases in intermediate and high-risk primary prostate cancer.  Fluciclovine F18 PET-CT scanning is predictive for the detection of regional lymph node metastases. The detection of metastases is a critical factor affecting the choice of initial treatment for patients with prostate cancer, and our data support the utility of fluciclovine F18 PET-CT scanning as an aid to the detection of metastases in patients with high-risk prostate cancer.

Additional Content on the use of Fluciclovine (18F) PET/CT in Prostate Carcinoma

Fluciclovine F18 PET-CT scanning in patients with high-risk primary prostate carcinoma

Fluciclovine F18 (FACBC): An Amino Acid Tracer for the Staging of Recurrence Prostate Cancer

Comparison of PSMA-based 18F-DCFBC PET/CT to Conventional Imaging Modalities for Detection of Hormone-Sensitive and Castration-Resistant Metastatic Prostate Cancer.

EVERYDAY UROLOGY: Axumin™ [Fluciclovine F18]: An Accurate Imaging Approach for Patients with Biochemically Recurrent Prostate Cancer-Full text article

Watch: 18F-Fluciclovine: A New Option for Biochemical Recurrence in Prostate Cancer - Trond V. Bogsrud
Watch: New Hot Topic: Axumin™ (Fluciclovine F 18) Injection for PET Imaging of Recurrent Prostate Cancer - Phillip Koo
Watch: Using Fluciclovine in the Recurrent Prostate Cancer Patient- David Schuster
Watch: Cristina Nanni on Flucicovine F18 (FACBC) in Prostate Cancer - State of the Art Presentation


Trond V. Bogsrud, MD, PHD, Oslo University Hospital, Department of Radiology and Nuclear Medicine