Clinical Trials in Progress VL

Phase II Trial for BCG Unresponsive Non-Muscle Invasive Bladder Cancer - Michael Woods

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Joining Alicia Morgans, MD, MPH, is Michael Woods, MD, who is the leader of the Alliance trial A031803, a phase II trial studying how well gemcitabine with pembrolizumab works in treating patients with non-muscle invasive bladder cancer (NMIBC) who are unresponsive to bacillus Calmette-Guérin (BCG). This phase II trial studies the effect of adding pembrolizumab to gemcitabine in treating patients...

Evaluating the Benefit of Rucaparib and Enzalutamide Combination Therapy Vs. Enzalutamide Alone for the Treatment of mCRPC - the Phase III CASPAR Trial - Arpit Rao

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The University of Minnesota has recently launched the CASPAR randomized Phase III clinical trial of enzalutamide and rucaparib versus enzalutamide and placebo in first-line metastatic castrate-resistant prostate cancer (CRPC). Alicia Morgans is joined by Arpit Rao from the Univesity of Minnesota to discuss the launch and the initial success of this new trial. Biographies: Arpit Rao, MD, MBBS, Assi...

Intensive Androgen Deprivation in High-Risk Biochemically Recurrent Prostate Cancer Patients - Alliance Foundation Trial (AFT19) - Rahul Aggarwal

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Joining Alicia Morgans to highlight The Alliance Foundation (AFT-19) trial is Rahul Aggarwal from the UCSF Helen Diller Family Comprehensive Cancer Center. The AFT-19 trial started enrolling in March 2017 and is looking at intensive androgen deprivation therapy (ADT) in high-risk biochemically recurrent prostate cancer (BCRP) patients. It is a randomized open-label, three-arm phase 3 study. AFT-19...

Genitourinary Cancers Symposium 2021 Trials in Progress TROPiCS-04 - Petros Grivas

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Petros Grivas discusses the upcoming ASCO GU 2021 meeting that opens on Thursday, February 11, 2021. Dr. Grivas will be presenting a "Trials in Progress" on the study of sacituzumab govitecan (IMMU-132) in metastatic or locally advanced unresectable urothelial cancer (TROPiCS-04). This is a Phase III, global, multicenter, open-label randomized controlled trial in which approximately 600 subjects w...

The PDIGREE Trial - Define Rational Sequencing in Combination Treatment of mRCC - Tian Zhang

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Principal investigator Tian Zhang joins Alicia Morgans to discuss the recent progress of the currently enrolling PDIGREE (Alliance A031704) trial. PDIGREE: An Adaptive Phase III Trial of PD-Inhibitor Nivolumab and Ipilimumab with VEGF TKI Cabozantinib in Metastatic Untreated Renal Cell Cancer (Alliance A031704) has been open since May of 2019 and now has nearly 300 patients enrolled, many of whom...

The Alliance Trial A031801 - RadiCal a Trial of Radium-223 in Patients with Renal Cell Carcinoma, - Rana McKay

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Potentially practice-changing study sponsored by the National Cancer Institute — A discussion with Rana McKay, MD, principal investigator. Radium-223 (223Ra) is an alpha particle-emitting radioactive agent that received Federal Drug Administration (FDA) approval in 2013 to treat patients with castration-resistant prostate cancer, symptomatic bone metastases, and no known visceral metastatic diseas...

PDIGREE: An adaptive phase III trial of PD-inhibitor Nivolumab and Ipilimumab (IPI-NIVO) with VEGF TKI Cabozantinib (CABO) in Metastatic Untreated RCC (Alliance A031704). -Tian Zhang

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PDIGREE is a novel adaptive frontline immunotherapy study which upon completion will help answer many important questions regarding treatment duration, when to combine VEGF therapy with IO therapy, and which patients benefit most from IO-VEGF combination upfront vs. sequential therapy. This trial is actively enrolling patients at all National Clinical Trials Network (NCTN) study sites. The primary...

Implementing Prostate Cancer Working Group 3 Criteria in Clinical Trials- Michael Morris and Lawrence Schwartz

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Alicia Morgans welcomes Michael Morris and Lawrence Schwartz to discuss the Prostate Cancer Working Group criteria as a refresher for investigators who are treating men with prostate cancer in clinical trials. Biographies: Michael J. Morris, MD., is the Clinical Director, Genitourinary Medical Oncology Service & Prostate Cancer Section Head, Division of Solid Tumor Oncology, Memorial Sloan Ketteri...

The DORA Trial, Comparing Overall Survival in Patients Treated with Docetaxel vs. Docetaxel plus Radium-223 - Michael Morris

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Michael Morris, Professor of Medicine and GU Medical Oncologist, Memorial Sloan Kettering Cancer Center joins Alicia Morgans at the 26th Annual Prostate Cancer Foundation Scientific Retreat (PCF 2019) to discuss the DORA trial. Michael Morris is The DORA trial principal investigator for this Prostate Cancer Clinical Trials Consortium (PCCTC) trial. The primary objective of this study is to compare...

Count Me In! The Metastatic Prostate Cancer Project - Eliezer Van Allen

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Eli Van Allen shares details on The Metastatic Prostate Cancer Project, a project part of a larger nationwide genomic research project called "Count Me In" for men with advanced or metastatic prostate cancer. The Metastatic Prostate Cancer Project takes a new approach to cancer research in which researchers partner directly with men with metastatic and/or advanced prostate cancer, who share their...