Localized Prostate Cancer COE

Clinical Implications of the Study Findings from the Radiotherapy Adjuvant Versus Early Salvage ((TROG 08.03/ANZUP RAVES) Trial - Andrew Kneebone and Declan Murphy

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Men who undergo surgery as definitive therapy for their localized prostate cancer generally only receive subsequent radiation therapy if their surgical pathology shows high-risk adverse pathologic features (adjuvant radiotherapy) or if they experience biochemical recurrence (salvage radiotherapy). Adjuvant radiotherapy versus early salvage radiotherapy following radical prostatectomy (TROG 08.03/A...

(TROG 08.03/ANZUP RAVES) Phase 3 Trial on Adjuvant Radiotherapy Versus Early Salvage Radiotherapy Following Radical Prostatectomy Journal Club - Christopher Wallis & Zachary Klaassen

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Christopher Wallis and Zachary Klaassen provide an in-depth review of the Lancet Oncology publication "Adjuvant radiotherapy versus early salvage radiotherapy following radical prostatectomy (TROG 08.03/ANZUP RAVES): a randomised, controlled, phase 3, non-inferiority trial" in this UroToday Journal Club. Biographies: Christopher J.D. Wallis, MD, Ph.D., Instructor in Urology, Vanderbilt University...

Prostate Active Surveillance Study (PASS) - Daniel Lin

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The Canary Prostate Active Surveillance Study (PASS) is a multi-center research study for men who have chosen active surveillance to manage their prostate cancer. Canary is the world’s only non-profit focused solely on early cancer detection. Active surveillance in PASS means closely monitoring men with prostate cancer and offering treatment if test results show the cancer is getting worse. This i...

How Can We Accelerate Clinical Trial Accrual in Localized Prostate Cancer? - Brian F. Chapin

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Brian Chapin, MD, joins Matthew Cooperberg, MD, MPH, FACS, in conversation discussing conceiving and executing large phase III trials focused on the management of localized prostate cancer. Dr. Chapin highlights what it takes to get one of these trials off the ground and what the future of trials looks like for men with localized disease. He specifically highlights the actively recruiting Phase II...

An Expert Discussion on Gleason 6 (Grade Group 1) Prostate Cancer - Scott Eggener

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Historically called Gleason 6, and more recently referred to as Grade Group 1, is a term that started in the 1960s with Don Gleason's original description. It was more universally adopted by the late 1980s, and the Grade Group system was initiated in 2014. In this conversation with Matthew Cooperberg, MD, MPH, FACS, Scott Eggener, MD offers his perspective on the importance of understanding Gleaso...

MRI Versus Ultrasound for Prostate Cancer - Samir Taneja

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Samir Taneja joins a panel of urologists to debate the use of ultrasound when compared to magnetic resonance imaging (MRI) as the best diagnostic and guidance imaging option for prostate cancer patients. Prostate ultrasound, specifically, micro-ultrasound, has a high sensitivity for predicting clinically significant cancer however its diagnostic accuracy is dependent on the urologist performing th...

Active Surveillance for Low-Risk Prostate Cancer - Laurence Klotz and Peter Carroll

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Matt Cooperberg hosts a discussion with Peter Carroll and Laurence Klotz examining their roles in the progress of active surveillance for low-risk prostate cancer and how they incorporate this treatment into clinical practice. They discuss the change in the field from over-detection and overtreatment where radiation and surgery were the primary treatment options to the evolution of active surveill...

Data from the RTOG 9601 Study: Treating Prostate Cancer Patients with Low-Volume Disease - Daniel Spratt

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At the 26th Annual Prostate Cancer Foundation Scientific Retreat (PCF 2019), Daniel Spratt joins Charles Ryan to discuss an update of the Shipley data (NEJM 2017) from the RTOG 9601 study. The question discussed is how should we be treating patients who have favorable, lower-volume disease? They also assess the antiandrogen therapy, bicalutamide, that was used in this study versus those available...

Study of Baseline PSA Screening of Men (45 years old) - Peter Albers

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Peter Albers discusses his study of baseline PSA screening of young men across the nation of Germany. The study consists of 45-year-old men who are randomized in two cohorts, one group gets a PSA immediately and the other cohort has a delay of five years. The initial PSA value determines the patient’s risk-adapted strategy and dictates the schedule of further testing. Dr. Albers states that the tr...

Epidemiologic Outcomes of Prostate Cancer Patients Undergoing Active Surveillance - Sigrid Carlsson

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Sigrid Carlsson joins Charles Ryan discussing the epidemiologic outcomes of men in the current era who are facing active surveillance. She reviews the long term data learned from the Memorial Sloan Kettering Cancer Center Experience which mirrors prior reports with low rates of metastasis or cancer-related deaths for patients on active surveillance. They also discuss the migration of pushing the e...
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