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- Sam Chang converses with Helen Hougen about her presentation on predictive biomarkers for upper tract urothelial carcinoma (UTUC) at the SUO, emphasizing their critical role in risk stratification. They delve into the limitations of current diagnostic tools like ureteroscopic biopsies, which often provide imperfect information and pose significant patient burdens. Highlighting the promise of minim...
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- Sam Chang engages with Jennifer Linehan to discuss topical chemotherapy for upper tract urothelial carcinoma, particularly utilizing UGN-101 (Jelmyto). Dr. Linehan shares her invaluable insights and experiences, primarily from the OLYMPUS trial, highlighting the evolution in administration methods for UGN-101, transitioning from retrograde to the more convenient antegrade approach via a nephrostom...
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- Sam Chang engages in a detailed discussion with Hristos Kaimakliotis, who presents findings from a multi-institutional review he authored, focusing on real-world practices with Jelmyto, a treatment for upper tract urothelial cancer. The study explores the efficacy of mitomycin reverse thermal gel, UGN-101, which has shown promise in ablating low-grade upper tract urothelial cancer. The OLYMPUS tri...
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- In a case presentation, Zach Klaassen and Kyle Rose discuss the complexities of treating low-grade upper tract urothelial carcinoma. Dr. Rose presents a case of a 69-year-old male patient with the condition, emphasizing the importance of thorough workup and staging. The discussion covers the challenges of accurate biopsy sampling and the potential for under-staging or over-staging patients. Dr. Ro...
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- Zachary Klaassen is joined by Rashid Sayyid to present a case-based discussion on the management of low-grade upper tract urothelial carcinoma. They focus on a 68-year-old female patient, detailing her medical history, symptoms, and diagnostic workup, including CT urogram, according to the American Urological Association (AUA) guidelines. They explore various considerations such as standardized re...
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- Sam Chang and Sarah Psutka discuss the importance of personalized prescriptions and rehabilitation in urologic oncology, with an emphasis on frailty evaluation and prehabilitation. Dr. Psutka urges the shift from subjective preoperative risk to objective measures for better treatment outcomes, using Comprehensive Geriatric Assessments (CGA) and anatomic assessments, while highlighting the correlat...
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- Diagnosed with upper tract urothelial carcinoma, Michael Miller is initially shaken by the possibility of losing his kidney. However, he finds a less invasive alternative with JELMYTO®, a treatment offered at the Georgia Cancer Center. The process involves six weekly infusions, with minimal discomfort and disruption to his daily life. Despite a minor infection, the procedure is smooth, and he succ...
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- In the wake of being diagnosed with upper tract urothelial cancer (UTUC), patient Tom Murphy navigates through his treatment options, ultimately settling on JELMYTO® (mitomycin) treatment. This less invasive procedure consists of six weekly treatments which were, according to Murphy, relatively simple and unobtrusive to his everyday life. Expressing gratitude for the guidance and support of his me...
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- Sam Chang interviews Jonathan Coleman and Wesley Yip. They delve into a Journal of Urology article detailing promising advancements in treating upper tract disease using photodynamic therapy, a non-invasive treatment method developed by Drs. Coleman and Yip. Their study seeks to decrease over-treatment of the disease, which often results in unnecessary kidney removal. Preliminary results show 50%...
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- In a cross-institutional study investigating the impact of nephroureterectomy on renal function, urologist Clara Cerrato and her international team analyzed data from 576 patients across 17 tertiary centers. They discovered factors such as age, hydronephrosis, and postoperative day one acute kidney injury were independently associated with the estimated glomerular filtration rate (eGFR) variation....
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