Bladder Cancer COE

Trimodal Therapy in Urothelial vs Non-Urothelial Bladder Cancer - Mario de Angelis

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Sam Chang host Mario de Angelis to discuss a study on trimodal therapy (TMT) for urothelial and non-urothelial invasive bladder cancer. Dr. De Angelis presents findings from a SEER database analysis of over 5,000 patients treated with TMT. The study reveals that TMT use has increased for organ-confined urothelial carcinoma but decreased for non-urothelial cases. For organ-confined disease, patient...

The Best of ASCO 2024 in Advanced Bladder Cancer - Shilpa Gupta

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Ashish Kamat interviews Shilpa Gupta about the best of ASCO 2024 in advanced bladder cancer. Dr. Gupta discusses three abstracts: the CheckMate-901 trial's analysis of complete responders to Nivolumab plus gemcitabine-cisplatin in lymph node-only metastatic urothelial cancer; patient-reported outcomes from the EV-302 trial comparing enfortumab vedotin plus pembrolizumab to platinum chemotherapy; a...

Small Cell Neuroendocrine Carcinoma of Urinary Tract: Relapse Factors & Treatment - Omar Alhalabi

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Ashish Kamat interviews Omar Alhalabi about research on small cell neuroendocrine carcinoma of the urinary tract. Dr. Alhalabi discusses the study's findings on prognostic factors for relapse in surgically resected cases. The research reveals that neoadjuvant chemotherapy benefits patients, while the persistence of small cell carcinoma at surgery is associated with a high risk of relapse. The stud...

dMMR and MSI-H in Urothelial Carcinoma: Prevalence and Treatment Implications - Elias Chandran

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Sam Chang interviews Elias Chandran about a systematic review and meta-analysis on mismatch repair deficiency (dMMR) and microsatellite instability (MSI-H) in urothelial carcinoma. Dr. Chandran presents findings showing higher prevalence of dMMR and MSI-H in upper tract urothelial carcinoma compared to bladder cancer, with greater frequency in localized disease than metastatic disease. The study s...

Robotic vs. Open Radical Cystectomy: 3-Year RCT Results Revealed - Giuseppe Simone

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Ashish Kamat hosts Giuseppe Simone to discuss a randomized trial that compares robotic-assisted radical cystectomy with completely intracorporeal urinary diversion to the traditional open approach. Published three-year outcomes demonstrate a notable reduction in preoperative transfusion rates for the robotic approach, though costs were higher due to surgical devices. Functional outcomes such as ni...

Advancing Female Bladder Cancer Care: Insights from AUA's First Specialized Course - Armine Smith

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Ashish Kamat introduces Armine Smith to discuss the intricacies of treating female bladder cancer, emphasizing organ and sexual function preservation during radical cystectomy. Highlighting a groundbreaking course at the AUA, Professor Smith explores significant topics like patient selection, operative techniques, and postoperative care. The course, a first of its kind, addresses the disparities i...

Orion Study Explores New Paclitaxel-Hyaluronic Acid Conjugate for BCG-Unresponsive Bladder Cancer - Sunil Patel

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Sam Chang interviews Sunil Patel about the Orion Bladder Cancer Study. The phase 3 single-arm study evaluates the efficacy and safety of a paclitaxel-hyaluronic acid conjugate, ONCOFID-P-B, administered intravesically for patients with BCG-unresponsive CIS of the bladder. This novel agent targets CD44, overexpressed in bladder cancer cells, and has shown promising results with a high complete resp...

Patient Burdens and Openness to In-Home Intravesical Therapy for Bladder Cancer - Timothy Lyon & Amanda Myers

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Sam Chang hosts Amanda Myers and Tim Lyon to discuss the burdens of intravesical therapy for bladder cancer. Dr. Myers shares insights from their study on the patient-reported treatment burdens, revealing significant challenges related to travel, cost, and daily life disruptions due to the current clinic-based treatment setup. The study suggests a strong patient interest in transitioning to in-hom...

Optimizing Next-Generation Sequencing in Urothelial Cancer: Expert Consensus Recommendations - Andrea Necchi

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Ashish Kamat engages with Andrea Necchi about the use of next-generation sequencing (NGS) in urothelial carcinoma. Dr. Necchi highlights consensus recommendations from a recent retreat, emphasizing the importance of NGS in identifying actionable mutations across different stages of bladder cancer. He underscores the need for careful tissue management, recommending NGS especially when clinical tria...

MoonRISe-1: Evaluating TAR-210 for Intermediate-Risk Non-Muscle-Invasive Bladder Cancer - Roger Li

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Sam Chang interviews Roger Li about the MoonRISe-1 trial. This phase 3 study explores the use of TAR-210, an innovative intravesical delivery system for the tyrosine kinase inhibitor erdafitinib, targeting patients with intermediate-risk non-muscle-invasive bladder cancer harboring FGFR alterations. Dr. Li explains that TAR-210, administered via a quick in-office procedure, continuously releases e...