Continent catheterizable tubes/stomas in adult neuro-urological patients: A systematic review

To systematically review all available evidence on the effectiveness and complications of continent cutaneous stoma or tube (CCS/T) to treat bladder-emptying difficulties in adult neuro-urological patients.

The search strategy and studies selection were performed on Medline, Embase, and Cochrane using the PICOS method according to the PRISMA statement (CRD42015019212; http://www.crd.york.ac.uk/PROSPERO).

After screening 3,634 abstracts, 11 studies (all retrospective, enrolling 213 patients) were included in a narrative synthesis. Mean follow-up ranged from 21.6 months to 8.7 years (median: 36 months, IQR 28.5-44). At last follow-up, the ability to catheterize rate was ≥84% (except in one study: 58.3%) and the continence rate at stoma was >75%. Data comparing health-related quality-of-life before and after surgery were not available in any study. Overall, 85/213 postoperative events required reoperation: 7 events (7 patients) occurring ≤3 months postoperatively, 22 events (16 patients) >3 months, and 56 events (55 patients) for which the time after surgery was not specified. Sixty additional complications (60 patients) were reported but did not require surgical treatment. Tube stenosis occurred in 4-32% of the cases (median: 14%, IQR 9-24). Complications related to concomitant procedures (augmentation cystoplasty, pouch) included neovesicocutaneous fistulae, bladder stones, and bladder perforations. Risk of bias and confounding was high in all studies.

CCS/T appears to be an effective treatment option in adult neuro-urological patients unable to perform intermittent self-catheterization through the urethra. However, the complication rate is meaningful and the quality of evidence is low, especially in terms of long-term outcomes including the impact on the quality-of-life.

Neurourology and urodynamics. 2017 Jan 31 [Epub ahead of print]

Véronique Phé, Romain Boissier, Bertil F M Blok, Giulio Del Popolo, Stefania Musco, David Castro-Diaz, Bárbara Padilla Fernández, Jan Groen, Rizwan Hamid, Lisette 't Hoen, Hazel Ecclestone, Thomas M Kessler, Tobias Gross, Marc P Schneider, Jürgen Pannek, Gilles Karsenty

Department of Urology, Pitié-Salpêtrière Academic Hospital, Assistance Publique-Hôpitaux de Paris, Paris 6 University, Paris, France., Department of Urology, La Conception Hospital, Assistance Publique-Hôpitaux de Marseille, Aix-Marseille University, Marseille, France., Department of Urology, Erasmus Medical Center, Rotterdam, The Netherlands., Department of Neuro-Urology, Careggi University Hospital, Florence, Italy., Department of Urology, Hospital Universitario de Canario, Universidad de La Laguna, Tenerife, Spain., Department of Neuro-Urology, London Spinal Injuries Centre, Stanmore, United Kingdom., Department of Neuro-Urology, Spinal Cord Injury Center & Research, University of Zürich, Balgrist University Hospital, Zürich, Switzerland., Department of Urology, University of Bern, Inselspital, Bern, Switzerland., Department of Neuro-Urology, Swiss Paraplegic Center, Nottwil, Switzerland.