Rotigotine Effects on Bladder Function in Patients with Parkinson's Disease.

The objective of this study was to assess the effect of rotigotine treatment on bladder function in patients with Parkinson's disease (PD) who have urinary urgency.

in total, 20 patients with PD underwent urodynamic evaluation and completed International Prostate Symptoms questionnaires in off-rotigotine condition and after 3 months of rotigotine patch monotherapy administration. In both sessions, clinical motor condition was evaluated with the Unified Parkinson Disease Rating Scale, Part III (motor part).

Rotigotine administration significantly ameliorated the first sensation of bladder filling, the neurogenic detrusor overactive contractions threshold and bladder capacity compared with the off-treatment condition. Moreover, the total score on the International Prostate Symptoms questionnaire revealed a decrease of filling (irritative) symptoms after rotigotine treatment compared with the off-treatment condition.

The positive effects of rotigotine may be due to its balanced agonism to D1 and D2 receptors and in particular to its stimulation of D1 receptors in the anterior cingulate cortex and insula, which are known as areas involved in bladder-inhibitory functions.

Movement disorders clinical practice. 2017 Apr 19*** epublish ***

Livia Brusa, Filomena Petta, Giuseppe Farullo, Valerio Iacovelli, Viviana Ponzo, Cesare Iani, Paolo Stanzione, Enrico Finazzi Agró

Neurology Unit Sant'Eugenio Hospital Rome Italy., Department of Surgery/Urology Tor Vergata University Rome Italy., Noninvasive Brain Stimulation Unit Clinical and Behavioral Department Fondazione Santa Lucia IRCCS Rome Italy., Department of Systems Medicine Tor Vergata University Rome Italy.