Impact of the medical specialty on knowledge regarding multidrug-resistant organisms and strategies toward antimicrobial stewardship

Evidence is scarce on subject-specific knowledge of multidrug-resistant organisms and rational use of antibiotics. We aimed at evaluating attitude, perception, and knowledge about multidrug-resistant organisms (MDRO) and antibiotic prescribing among urologists versus other medical specialties.

Within the MR2-study (Multiinstitutional Reconnaissance of practice with MultiResistant bacteria), a questionnaire was conducted targeting general surgeons, internists, gynecologists, and urologists in 18 German hospitals. The influence of medical specialty on predetermined endpoints was assessed by multivariable logistic regression models.

With 456 evaluable questionnaires, the response rate was 43% (456/1061). Within seven workdays prior to survey, urologists prescribed antibiotics to >5 patients more often than non-urologists (50.7 vs. 24.3%; p < 0.001). Urologists were more confident regarding dosage, frequency, and duration of antibiotic treatment (p = 0.038) as well as in interpreting antibiograms (p < 0.001). Both urologists and non-urologists had poor knowledge about antibiotic stewardship. Urologists were more confident regarding local resistance patterns (p < 0.001). However, local rates of ciprofloxacin-resistant E. coli strains were correctly categorized by only 36.3 and 31.2% of urologists and non-urologists, respectively (p = 0.168). Compared to non-urologists, urologists more often acknowledged the use of broad-spectrum antibiotic agents as a problem, potentially resulting in increased resistance pattern (p = 0.036). Conversely, 31.5 and 30.7% of urologists and non-urologists (p = 0.424), respectively, would prescribe broad-spectrum antibiotics to a female patient with an uncomplicated urinary tract infection. Urologists did not attend more training courses regarding multidrug-resistance or antibiotic prescribing and did not perceive a better quality of discharge letters regarding MDRO.

There is substantial need for advanced training regarding MDRO and antibiotic stewardship, regardless of medical specialty.

International urology and nephrology. 2017 Apr 21 [Epub ahead of print]

Steffen Lebentrau, Christian Gilfrich, Malte W Vetterlein, Harald Schumacher, Philipp J Spachmann, Sabine D Brookman-May, Hans M Fritsche, Martin Schostak, Florian M Wagenlehner, Maximilian Burger, Matthias May, MR2 study group

Department of Urology and Pediatric Urology, Brandenburg Medical School, Ruppiner Kliniken, Fehrbelliner Straße 38, 16816, Neuruppin, Germany. ., Department of Urology, St. Elisabeth Hospital, St.-Elisabeth-Str. 23, 94315, Straubing, Germany., Department of Urology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany., Department of Urology, Caritas St. Josef Medical Center, University of Regensburg, Landshuter Straße 65, 93053, Regensburg, Germany., Department of Urology, LMU Munich, Großhadern, Marchioninistraße 15, 81377, Munich, Germany., Department of Urology and Pediatric Urology, Magdeburg University Medical Center, Otto-von-Guericke University, Leipziger Str. 44, 39120, Magdeburg, Germany., Department of Urology, Pediatric Urology and Andrology, Justus-Liebig University, Rudolf-Buchheim-Str. 7, 35392, Giessen, Germany.