The aim of this population-based retrospective cohort study was to investigate the onset of urinary tract infection in newborns and the associated risks of childhood asthma.
Children with neonatal UTI (n = 3,312) and randomly selected controls (n = 13,243) were enrolled for our analysis. We calculated the follow-up person-years for each participant from the index date until the diagnosis of asthma, the end of 2008, or withdrawal from the insurance system (because of death or loss to follow-up). Furthermore, we compared the risk of asthma between non-UTI and UTI cohorts by using Cox proportional hazards model analysis, the adjusted hazard ratio (aHR), and a 95 % confidence interval (95 % CI). The overall asthma incidence rate was found to be 1.53-fold significantly higher in the UTI cohort than in the non-UTI cohort (70.3 vs 45.8 per 1000 person-years). After we adjusted for potential risk factors, the overall risk of asthma remained higher in the UTI cohort (aHR = 1.47, 95 % CI = 1.35-1.59). The incidence rate was higher in boys than in girls. Overall, patients suffering from UTI may have a greater risk of developing asthma than patients without UTI. This nationwide retrospective cohort study demonstrates that neonatal UTI may increase the risk of childhood asthma.
Lin CH, Wang YC, Lin WC, Kao CH. Are you the author?
Department of Pediatrics Children's Hospital, China Medical University Hospital, Taichung, Taiwan.
Reference: Eur J Clin Microbiol Infect Dis. 2015 May 24. Epub ahead of print.