Urinary tract infections caused by extended-spectrum beta-lactamase-producing bacteria in children: A matched case control study - Abstract

Extended-spectrum beta-lactamase (ESBL)-producing pathogens are emerging as a cause of urinary tract infections (UTI) worldwide.

In this matched-case control study, clinical characteristics and associated risk factors for ESBL UTI were evaluated. In a total of 463 positive urine cultures, 48 (10.4%) (from 39 patients, 23 boys) were phenotypically ESBL-producing bacteria. The most frequently isolated microorganism was , followed by Klebsiella spp. and Enterobacter cloacae. Children with ESBL UTI (n=39) were on prophylaxis more (21% vs. 6%, p=0.01), had higher rates of urinary tract anomalies (36% vs. 10%, p=0.0007), presented abnormal 99m Tcdimercaptosuccinic acid (DMSA) findings (i.e. scars) (23% vs. 4%, p=0.001), and had longer hospitalization (9.8 vs. 7.4 days, p=0.004) compared to those with non-ESBL UTI (n=117). The recognition of risk factors for UTI caused by ESBL bacteria in children may aid in the identification of high-risk cases and may enable proper management of these patients.

Written by:
Dotis J, Printza N, Marneri A, Gidaris D, Papachristou F.   Are you the author?
Department of Pediatrics, Aristotle University, Hippokratio Hospital, Thessaloniki, Greece.  

Reference: Turk J Pediatr. 2013 Nov-Dec;55(6):571-4.

PubMed Abstract
PMID: 24577973

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