Infections

Laboratory diagnosis of urinary tract infections: Towards a BILULU consensus guideline

The BILULU study group consists of seven microbiologists of hospital laboratories located in the region of Flanders (Belgium). A major goal of the group is to standardize diagnostic microbiology procedures based on available evidence and, in the absence of evidence, based on general microbiological principles and expert opinion.

Efficacy and Safety of Finafloxacin versus Ciprofloxacin in the Treatment of Complicated Urinary Tract Infections: An Explorative Randomized Phase II Clinical Study

The broad spectrum C-8-cyano-fluoroquinolone finafloxacin displays enhanced activity at acidic conditions. This phase II clinical study compared efficacy and safety of finafloxacin and ciprofloxacin in patients with complicated urinary tract infection and/or pyelonephritis.

Urine Trouble: Should We Think Differently About UTI? - Beyond the Abstract

Urinary Tract Infection (UTI) is widely considered to be a result of pathogenic bacteria colonizing the sterile environment of the bladder. However, the recent discovery of resident communities of bacteria (microbiota) in the bladders of both women [1-9] and men [10-11] challenges this concept. If the bladder and thus urine are not normally sterile, then the definition of infection must move beyond the mere presence of bacteria. We believe that we must revisit the contemporary description of UTI by identifying its limitations: the language of UTI, testing for a UTI, an Escherichia coli-centric view of UTI, and a threshold-based diagnosis for UTI. As the science of the urinary microbiome moves forward, we much acknowledge each of these aspects of UTI or, as our title suggests, ‘urine trouble.’

Surviving Fournier's gangrene: Multivariable analysis and a novel scoring system to predict length of stay

There is no contemporary scoring system to predict hospital length of stay and morbidity in Fournier's gangrene. A retrospective study was conducted to formulate a scoring system to predict duration of hospitalization, resource utilization, need for reconstruction, morbidity and mortality.

Urine trouble: should we think differently about UTI?

Urinary tract infection (UTI) is clinically important, given that it is one of the most common bacterial infections in adult women. However, the current understanding of UTI remains based on a now disproven concept that the urinary bladder is sterile.

Trends in Antibiotic Resistance in Urologic Practice

The significant global upsurge in antimicrobial resistance, particularly among Enterobacteriaceae, represents a serious threat to health care systems. The implications for urologic practice are of particular concern.

GenomeDx to Distribute Pathnostics’ Guidance UGx Test for Urinary Tract Infection and Guidance PRx Test for Prostatitis

Truckee, CA (UroToday.com) GenomeDx Biosciences, a leader in the field of urologic genomics, and Pathnostics, a provider of comprehensive and dynamic pathology services, announced a strategic agreement for GenomeDx’s distribution of Pathnostics’ Guidance UGx and Guidance PRx. These molecular diagnostic tests for urinary tract infections (UTIs) and prostatitis, respectively, improve upon traditional urine culture by detecting the genomic sequence of pathogens, providing a faster and more comprehensive solution for physicians and their patients. 

Involvement of signal peptidase I in Streptococcus sanguinis biofilm formation

Biofilm accounts for 65-80 % of microbial infections in humans. Considerable evidence links biofilm formation by oral microbiota to oral disease and consequently systemic infections. Streptococcus sanguinis, a Gram-positive bacterium, is one of the most abundant species of the oral microbiota and it contributes to biofilm development in the oral cavity.

Non-surgical management of recurrent urinary tract infections in women

One in three women will experience a clinically significant urinary tract infection (UTI) by age twenty-four and almost half will have at least one in their lifetime. Recurrent UTIs (rUTIs) are defined as having greater than two infections in a 6-month period, or three infections over twelve months, with complete resolution for at least two weeks.

Stromal Cell-Derived Factor 1 Mediates Immune Cell Attraction upon Urinary Tract Infection

Urinary tract infection (UTI) is the most common type of bacterial infection in humans. Fifty percent of all women will experience at least one UTI in their lifetime, with uropathogenic Escherichia coli (UPEC) accounting for 80% of reported cases.

[Community acquired urinary tract infections - association with risk factors : Changes in causative organisms and resistance over time]

Published studies on community-acquired urinary tract infections (UTI) often do not link microbiological findings with clinical risk factors and patient data.

We retrospectively correlated clinical findings of all patients with UTI of a urological outpatient clinic with the respective microbiological analysis of their urine samples over 2 periods of time: (A: 2005-2006 and B: 2011-2012).

Acute focal bacterial nephritis is associated with invasive diagnostic procedures - a cohort of 138 cases extracted through a systematic review

Acute focal bacterial nephritis (AFBN) is a rare disease currently described only in case reports and small case series. In this study we summarize the clinical features of AFBN as has been documented in the literature and draw recommendations on the proper diagnosis and therapy.

Impact of the medical specialty on knowledge regarding multidrug-resistant organisms and strategies toward antimicrobial stewardship

Evidence is scarce on subject-specific knowledge of multidrug-resistant organisms and rational use of antibiotics. We aimed at evaluating attitude, perception, and knowledge about multidrug-resistant organisms (MDRO) and antibiotic prescribing among urologists versus other medical specialties.

Hospital-acquired Urinary Tract Infections in Neonatal ICU Patients: Is Voiding Cystourethrogram Necessary?

To evaluate the radiographic findings of neonatal intensive care unit (NICU) patients diagnosed with hospital-acquired urinary tract infection (UTI).

Children with no preexisting genitourinary anomalies undergoing a voiding cystourethrogram (VCUG) for culture-documented UTI during NICU admission were identified.

Is diabetes mellitus associated with clinical outcomes in aging males treated with transurethral resection of prostate for bladder outlet obstruction: implications from Taiwan Nationwide Population-Based Cohort Study

We assessed the lower urinary tract symptoms (LUTSs) and clinical outcomes between diabetes mellitus (DM) patients and non-diabetic (non-DM) patients receiving transurethral resection of prostate (TUR-P).

Shock due to urosepsis: A multicentre study

Urosepsis is a severe infection that can cause shock afterwards. The purpose of this study is to investigate the clinical and bacterial risk factors for shock in those cases with urosepsis caused by urinary tract infection in a multicentre study.

Yeast Mannan Oligosaccharide Dietary Supplement In the Treatment of Chronically Acute Urinary Tract Infections - Full Text

ABSTRACT:  Urinary tract infections (UTIs) are the most common bacterial infection experienced by women. Approximately 50 to 60% of all women in the United States will be diagnosed with UTIs at least once in their lifetime. Many of them develop recurrent infections; the frequency tends to increase with age. UTIs can be treated with antimicrobial drugs, although not without complications.

For reliable urine cultures in the detection of complicated urinary tract infection, do we use urine specimens obtained with urethral catheter or a nephrostomy tube?

The aim of this study was to compare the results of urine cultures obtained either from urethral, and percutaneous nephrostomy (PCN) catheters.

This study included 328 consecutive patients that underwent PCN at our institution with complicated urinary tract infections (UTIs) between July 2010 and April 2015.

Risk factors for bacteremia in urinary tract infections attended in the emergency department

Urinary tract infections (UTI) are common in emergency departments (ED), and at least 15% of them are bacteremic. However, there are few data on how to predict which patients are at high risk of developing bacteremic UTI (b-UTI).

Postrenal Failure due to Urinary Stones Associated with Acute Viral Gastroenteritis: Three Case Reports

Acute gastroenteritis with viral infection in infants causes severe diarrhea and often results in acute renal failure due to severe dehydration. However, a viral infection, particularly rotavirus, rarely induces postrenal failure due to bilateral stones in infants.

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