Featured Videos

ORLANDO, FL USA (UroToday.com) - Patients with small renal masses (SRM, ≤ 4cm) can be monitored by active surveillance (AS), but implications of growth rate (GR) in AS patients have yet to be fully elucidated. The authors hypothesize that variability of measurements on radiographic studies can lead to worrisome GR over short time intervals and should be tempered with the knowledge that GR of SRM are slow over extended time periods. Therefore they investigated growth patterns of patients with small renal masses.

auaIn this prospective study, patients were enrolled following consultation and choice of AS or intervention. Those electing AS followed an imaging protocol every 4-6 months for the first 2 years, then every 6-12 months for the next 3 years. Progression was defined as GR > 0.5cm/year, at which point intervention is recommended. GRs were calculated based on changes in the largest tumor dimension (cm) per year.

A total of 177 patients undergoing AS were enrolled in the study. Mean GR for the entire cohort was 0.19 cm/year with a significantly higher GR (0.52) within the first 182 days of AS (p=0.02). The percent of patients with GR progression was higher within the first 6 months of AS (p < 0.001). Of 21 patients electing to crossover, only 8 did so for elevated GR.

The study group showed that in patients with SRM undergoing AS, GR is slow on average (0.19cm/year). Dr. Readal pointed out that GR may be exaggerated on the first AS image based on the fact that small changes in growth over a short interval can produce rapid GR.

In conclusion clinicians should use early growth kinetics cautiously and temper their recommendation for intervention in the initial phase of AS to prevent over treatment.

Presented by Nathaniel Readal, MD at the American Urological Association (AUA) Annual Meeting - May 16 - 21, 2014 - Orlando, Florida USA

New York, NY USA

Written by Achim Lusch, MD, University of California (Irvine), and medical writer for UroToday.com


Clinical Trials
Searchable data base of currently enrolling clinical trials
Publications focusing on urological cancer treatments through original commentary & articles
Everyday Urology Volume 3 Issue 2

Everyday Urology™ - Oncology Insights

From the Editor

PCAN cover

Prostate Cancer and Prostatic Diseases

From the Editor


Newsletter subscription

Free Daily and Weekly newsletters offered by content of interest

The fields of GU Oncology and Urology are rapidly advancing. Sign up today for articles, videos, conference highlights and abstracts from peer-review publications by disease and condition delivered to your inbox and read on the go.


Upcoming educational events
November 23-25, 2018 / European Society for Medical Oncology Asia 2018 Congress
European Society for Medical Oncology Asia 2018 Congress
November 25-30, 2018 / RSNA 2018 Annual Meeting
RSNA 2018 Annual Meeting